Basic Information

Gene Symbol
-
Assembly
GCA_905404135.1
Location
FR990027.1:3070718-3083833[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 18 0.55 64 5.0 0.5 3 23 113 133 111 133 0.95
2 18 0.00083 0.095 13.9 0.1 2 23 137 159 136 159 0.95
3 18 0.19 22 6.5 1.5 2 23 385 407 384 407 0.95
4 18 0.016 1.9 9.9 0.1 1 20 415 434 415 435 0.96
5 18 0.00013 0.015 16.4 0.7 2 23 446 467 445 467 0.94
6 18 1.1 1.3e+02 4.1 0.6 1 23 483 506 483 506 0.85
7 18 0.0078 0.9 10.9 1.9 1 23 515 538 515 538 0.94
8 18 0.84 97 4.5 0.4 3 22 617 636 616 638 0.84
9 18 4.3 4.9e+02 2.2 1.6 1 23 643 666 643 666 0.91
10 18 8e-05 0.0092 17.1 1.2 1 23 672 694 672 694 0.96
11 18 7.3e-06 0.00084 20.4 1.9 1 23 701 723 701 723 0.98
12 18 6.9e-05 0.008 17.3 2.3 1 23 728 750 728 750 0.96
13 18 0.00029 0.033 15.4 1.5 1 23 756 778 756 778 0.98
14 18 1.4e-06 0.00016 22.6 1.4 1 23 784 806 784 806 0.98
15 18 0.00026 0.03 15.5 1.7 2 23 813 834 813 834 0.98
16 18 0.00029 0.034 15.4 0.8 2 23 842 864 841 864 0.97
17 18 0.00017 0.019 16.1 0.2 1 23 869 891 869 891 0.98
18 18 0.0048 0.56 11.5 0.8 1 23 897 920 897 920 0.97

Sequence Information

Coding Sequence
ATGGCGTCTGACGAATCAGACGATGAACCCTTGTCGTTATTGGCAGCAGCCAAGAAAAGCGATCCCTTGAAGTTTGAGTGCGAAATAATTCCCATACAAGATAAGACTTCTAAAAAGCGAAATACTTCAACTAAGAACACAAGTTTAACGATTAAAATAAACCGTCGACTGAAAACTGTAGCAGCGCCTCCAGTAATAGACAGACCCACTGATGTTTGGCTATATTTGAAAGATTTGAATCCAACTGGACCCTACAAATGCCTTCTCTGCGCAGATTGGTTTATAAATCGCTCCAAAATGGTAGTTCATTACGTTCTTAACCATAAAAAAGACTTTTGTGGCATCTGCAGGTATTTTGTTAATGACCGGGAAAGCTGGAAGTCACATGTCAAGTTTCATGAACCATGGCCGTGTTCTCAATGTGTGGAAACATTTCCCTCAGAATCATCTCTCCGGCAGCACCTCAGTTCGGTGCACCAGCTTGTCCACTGTCGTTTGTGCCACTTCAGGCTGCCAGTGGGTGAACAATATGATGCTCACTTGGGCCAGAAACACAATGTCTCAAATGTCAGTTGCAAGGATGAAAATTGTTTCTGGGAGTTAGAAGATGAACACGTACTAAAGTTCAACTGTTTCCTATGCACCAAGCAAAATAACTTAACATCCACATTCTTCCCTCACTACATGGGCTTTCATCACTTTACTCTCAAATGTATTACTTCCTTTATTTCTGGTACGGATCCACCATTCACTGTACACGGTGCTGAAATTAGCACGCAATTTGTTGATGGACAGTTGAAAGATTTGAATGCATTTGGTTATGTTGACATGGACCAAAAGCCCTTGGAAAGTCTCCTAGAAAATATTCAACCTGAGACTAAAGATCCACCAAAGCCAGTGAATGAAATAAAGAATGAAAGAACTGGATCTGATGAGCCAAAAGTTAATGAGAATTATACCAATAAAGTGGAGAACCAAGCTGACATCGAGGCATATGAGGGTGATGATGACTTTGATGTCACTCTAACAGAACTTATTATACTTCAAAGATGTTACTTTGACTATATTAAAAAGATATTGACTGATATCTCTCAGAACTTAGTCCCGGTGAACTCAGATATTAATAACAGGAATGATGTTGTTTTAAACGTCCAATGTCCTTTATGCGACAGTAAATTCCATACCGGACAATTGTTTATGAGTCATATGTACAAGATGCATAATGTTAAGTCCATTCCTAGTTACTCGTGTAGAGTATGTGGAACTAATTTTGACAGCCTTACTGAGCTGGATAGTCACATTGTGGATGAGATAAATAATTTTGAAAACTTGTGGATTTGTCAGTTTTGTGATAAGGAATTTACTAACCGAGAGAATGTTAGGAAACATCTGAGTGATCACTGGGAGGCTATAGAGTATGACAACTGTTTCAGCCCCCACTTAGGGTTTCGGTGCAAGTATTGTCCCACTCTGTTTTGGAATGAGACAGATCGGGAACAACATCAAGTTCGAGTACATTTCAATAAATACACGGATCAATTTTACAAATGCAGTAGTTGCTCTGTTACTTTTAGTGACAAGGTATGGTACATACACCATTACTTAGAAAATCATTTGAATGGAGAGAAAATGGGATCCTATCTGCTAAAATGCTGTGTGTGCTGTGTAGTTCTCACTAACATTGACGAGATGAGGACCCACTTCATTGAACACCACCCTGATGCAAGGAAGGTGTACTGCTCTCTAGACCCTTGTAAATACAAGCCTCTGAGTCAGCGAAAGTCTTTGAAACTGCATGTGAAGGCCGTCCACACGGTGCGCACGACTGGTCCAGAGAAGCCGGTGGCGTGCCCGGTGTGCACGCGCGAGTTCCCGTCGGCGCGCTCGTGCAACGCGCACGCCACGCAGGTGCACGGCCCCGGCAAGTTCAAGTGCAAGCTCTGCAAGGCCATGCTGCACACGCTGGACGAACGCAAGCTCCACTACCTGCTGATCCACCCGGGGCGGCACCCGTTCGAGTGCGCGGAGTGCGGCAAGTCGTTCCAGTACAAGTCCTCGCTCTACATGCACAAGCAGGACCACCTGCCCAACAAGCAGAGCTACACCTGCAACTACTGCAACAAGGAGTTTGTGAAGAAGGACTCGTTCCGCGAGCACCTGCAGATCCACGAGGGGCCGCGGCACGCGTGCTCGTACTGCCCCATGCGGTTCGTGCAGCGCTCCAACATGCTGCGCCACGAGCGGCGCCACACCGGCGAGCGCCCGTACGCCTGCCCGCACTGCCCGCGCACCTTCGCCGACAAGGGCGCCTGCACCTCGCACGCCAGGACGCATTCAAAGGAGTCATCTTACGCGTGTTTGTACTGCGGGCAGACGTTCGTGCAGAAGTCAAAGCTCACCTACCATATCAGAAAGCACACGGGTGAAAACCTGGAGACGTGTTCGATCTGCTCGAAGCTGTTCACGAGCGCGTGCGCGCTGCGCGAGCACATGAAGATCCACCTCTGCAAGAAGGAGTCCGTCAAGTGTCCGCTGTGTGACAAGAAGTACCAGGACGAGCGCTACATGCTGCGGCACCTGCGCACGTCGCACACGCGCACGCAGTTCTCGTGCCCGCTGTGCCAGAAGGTGGTCACCAGCGCCGTGGGCCTGCGCCACCACGTCATCACGCACAGCCCGCTCAACACCTTCCGTTGTAGAGTATGCCCAAAATCATATGCAGTGAAACGGACTATAGTGAAGCACTTACTGCGACGCCACTCGCTAAGCAGCTCCGAGGTGAATCTGAAGGACTATTACACTCGGTTGGAGCCGCGGCAGTGCAAACTGGAACTTGATGAGGAGACTATGACCAGAGTCTTCGGTCCTCCCAAAAAGAGGCCAGATATCCTCATAACGGACTTTGTAACTTACACACGGGATAAGAACCAGAAGAAAGAGGTGAAAGAGACAAGCGAACAGTCAGAGAAGGACAGCGATAGCAACTCTGACAACGACAGTTCGCAGAAAGAGAAACAACCGAAGATCAAAGAGGAAAGCCCCGAGGATATGGACCAAGATTATGGAGGCCACGAGTTGGAACCAACTGATTTTGTCAGTGTTAAGATTGAACATATGGAGGATGATGAGGTGGCATAG
Protein Sequence
MASDESDDEPLSLLAAAKKSDPLKFECEIIPIQDKTSKKRNTSTKNTSLTIKINRRLKTVAAPPVIDRPTDVWLYLKDLNPTGPYKCLLCADWFINRSKMVVHYVLNHKKDFCGICRYFVNDRESWKSHVKFHEPWPCSQCVETFPSESSLRQHLSSVHQLVHCRLCHFRLPVGEQYDAHLGQKHNVSNVSCKDENCFWELEDEHVLKFNCFLCTKQNNLTSTFFPHYMGFHHFTLKCITSFISGTDPPFTVHGAEISTQFVDGQLKDLNAFGYVDMDQKPLESLLENIQPETKDPPKPVNEIKNERTGSDEPKVNENYTNKVENQADIEAYEGDDDFDVTLTELIILQRCYFDYIKKILTDISQNLVPVNSDINNRNDVVLNVQCPLCDSKFHTGQLFMSHMYKMHNVKSIPSYSCRVCGTNFDSLTELDSHIVDEINNFENLWICQFCDKEFTNRENVRKHLSDHWEAIEYDNCFSPHLGFRCKYCPTLFWNETDREQHQVRVHFNKYTDQFYKCSSCSVTFSDKVWYIHHYLENHLNGEKMGSYLLKCCVCCVVLTNIDEMRTHFIEHHPDARKVYCSLDPCKYKPLSQRKSLKLHVKAVHTVRTTGPEKPVACPVCTREFPSARSCNAHATQVHGPGKFKCKLCKAMLHTLDERKLHYLLIHPGRHPFECAECGKSFQYKSSLYMHKQDHLPNKQSYTCNYCNKEFVKKDSFREHLQIHEGPRHACSYCPMRFVQRSNMLRHERRHTGERPYACPHCPRTFADKGACTSHARTHSKESSYACLYCGQTFVQKSKLTYHIRKHTGENLETCSICSKLFTSACALREHMKIHLCKKESVKCPLCDKKYQDERYMLRHLRTSHTRTQFSCPLCQKVVTSAVGLRHHVITHSPLNTFRCRVCPKSYAVKRTIVKHLLRRHSLSSSEVNLKDYYTRLEPRQCKLELDEETMTRVFGPPKKRPDILITDFVTYTRDKNQKKEVKETSEQSEKDSDSNSDNDSSQKEKQPKIKEESPEDMDQDYGGHELEPTDFVSVKIEHMEDDEVA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01082695;
90% Identity
iTF_00887635;
80% Identity
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