Hlin026494.1
Basic Information
- Gene Symbol
- Btbd7
- Assembly
- GCA_026182355.1
- Location
- JAPFBL010000255.1:5406350-5425399[-]
Transcription Factor Domain
- TF Family
- BTB
- Domain
- zf-C2H2|ZBTB
- PFAM
- PF00651
- TF Group
- Zinc-Coordinating Group
- Description
- The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 3 2.3e-13 3e-10 42.2 0.0 10 100 170 266 161 276 0.79 2 3 1.1e-06 0.0014 20.7 0.0 22 53 311 350 302 386 0.68 3 3 8.1 1.1e+04 -1.4 0.0 81 106 411 436 406 439 0.86
Sequence Information
- Coding Sequence
- ATGAGGCACAAGCCATTGATGATGTTGGGAAAAGAGAGATTTAACTGTTTGTTGTATGTTTGCAGAGGTGATGGTGGTATGAATGTAGTTTTGATTGGCTGCGTCGGATGCTGGAAGCCAAGGGGCAGCAGTGTGGACCATCCCATGTCTCCTCCGATGGGTGCTTCTCACTCCAATATCCCACCAACTCAAACTCCTCCCGATCTCCCGTCTCCAACGCAACCTCCACTCATCAATATAAGAGACAAGAAGAGGCTAAAGGTGGGAGGATTTGCAACATTGAGGAAGAAGCTAATGCGTCGGGGACGGCGTGGTTCGAAAGCTTTTGATCACGGACGAGTGATACGGGAGGCGGTGGCTGGTTGGTCATCCCTTGAGCTAACTGCCTTACTGGAAGAGTATGAGGCCCTTGCTGCACTCAAGGACCTTACTGTTCAAGCAGAGCTTGCCCGTCCTCCTGCTCCGACATACAAGCAAGATCTGTCCACTCTCTACGACTTTAAGTACTCCACTGATGTGGATCTGGTCTTCAGAGGTACCTGTTTCCCCGTGCACAGAGCACTCCTTTCTGCAAGGTGTCCGTATTTCAGAGATCTTCTTCAAGCATATCCTGGGTATGGTGCTCGTATCTGCTTGGAGCTTCCAAATAGTGGCGTGGACGTTGAAGTTTTTTCTGCTCTTTTGCGCTATCTTTATACTGGTGATTTTGTTTCTTCCCTGGGAACAGGGCCTCCACCTCCTGATGTTGCTACTCTTCGCAGACTCGGTGACCAGTTTGGTCACCCAAACCCTTTGGAACATGATTTAAAATACCTGTTAGAAACAGGGGAATATGCAGATGCAGCTCTCGTTTTCACGACTGGAGACTCTGGTGTTAATTCCAATTCGGAAAGAGCCGTTGGTAGCTGTTGCGAGTACGGTTTTAGGTTGGAGCTTCCTTGTCATAAGGCTATACTCTCTGCTAGAAGCCCGTTCTTCAGAAACCTTATCCAAAGAAGGACCAGGTCTGGTGAAGAACATACTGAGAGAGCTCTTCATATTCCAACTAGGATAGTTTTGGATGAGACTGTGATACCGAAAAGATATGCTAAGGTCTTACTGCATGCCATATACCTTGACACTGTTGACCTGGGGCTGATCATAAGAGGCAGTGGTTCTACGAGCACTGGAAGCCTCGGAGAAGCTGAGGCATTGACGTGTAATGGTGTACGATCAAGACCAACTCCACTGGAGGAGGCTATGGAACTCTACCAAATTGGTAGGTTTCTGGAACTTGATATTGTCTCCCAAGGCTGTGAGGACATCATACTAGAACTGCTAACGATTGAGTCACTACCAGGAGTTCTGCGTTGGGCGAGTGAAGGTCATGGATCAAGTTGGGTCCTGCGGCAGGCGCGGCACTTGCTCAACGAGGAGTTTGTTCAAGTCTCCCACTCCCCCGTGTTGTTCCAGTTGGATAAGGAACATCTTGTTCAGGCCTTATCTTCCCATTTCCTCCAGGCATCAGAATTAGATGTCCTTGTTGCAGTTCTTAAATGGGGTGAACACAAACTTGTTCGTACCATGCAAGACAGAGAACCAAATGTAGTTAGTCAGACTGCACATTCGGTAACGAGGAAGGGAATAAAGAAAAGAGATTTGAGTGACGTGGAGTTGAGAGAAGTGTTGTCCGAGCTATTGCCTCTCGTAAGGATGGATCACGTCATACCTTCGGACAGCGAGCCCCTCTCGCAAGCCATTAAGAGAGGCCTCGTCTCTAACCCTCCCAGTCACATGATAGGATCTGATCAGAGAGGAGGGGAAAGAATCAATGCTTGGGTGAGGACCTGGCAGCATGGTCAACATTCAGGGCTGTTTGTTAGACCTAGGCTTTTTATGCCGTACTATGAGGAAATCAAGGTGTTGGTGGGAGAAGAGCAAGTGGTGTCTGAAGCTGGAGATCCAGTTCGTCTGAGACGTGGAAGGTTCATGCGTGACATTCCTGACACTCTGTACATGGTCCACGAAAGACCCAACCCCAGTGTGGATGTACTCAGCCACAACTCACTTCCAGCTCCAGATGCTGCTACTATGTCGGCCATGGTGAAAAGGGAAGCCAAGCTGAGACAAAGCGCCACTTGTCAGCGAGCAGTTGCTCTTCCGCTCTCCTCGATAACTGAAATAAACAGGCAGATCAGACTCCGGGTCGTCAGGGAGTTTAACTTACCTGATCAAGTGGCGTCTCTTTTAGATAATGCTTCATGCTACCAAGTGGAAGATGAAGAGGAATTGGTGATTATGGGAATGGTGGGAGGAGGAGGAGAAGGAAATGGGCCGAGAACTGGCCGGAGTAGCGGAGGGGTGGCCCGACGCAGACGGCGGTCTCCTGGTCTACCCCACCAAGTGCCTCACCTGCACCAACCCGCTGCCCCCACCGTGCCACTGCCTGCCGTCGTGACGGAGGGCTCGCACCATCACCTGCATCTCCACCACCATCATCCTTCTACACCTCACTTACACCATACCTATCCTGCTCAGTGGTGTGGAGGCGAACAGCTAATGCCAGATGTAACTATGGCTACAGCCTCTCTGGACCACCTCAGCCTGAGTCCATCGCAACCGCAAACATCACGACTACCTTCCGGTGAAGGTGGTCTAGAACTGGACTTAGGAGATGGGCCTGTAGCACCTCCCATACCTACTTCTCGCAGGCTTACTCCACCTCCACCTCCTCATCGCTTCATATAG
- Protein Sequence
- MRHKPLMMLGKERFNCLLYVCRGDGGMNVVLIGCVGCWKPRGSSVDHPMSPPMGASHSNIPPTQTPPDLPSPTQPPLINIRDKKRLKVGGFATLRKKLMRRGRRGSKAFDHGRVIREAVAGWSSLELTALLEEYEALAALKDLTVQAELARPPAPTYKQDLSTLYDFKYSTDVDLVFRGTCFPVHRALLSARCPYFRDLLQAYPGYGARICLELPNSGVDVEVFSALLRYLYTGDFVSSLGTGPPPPDVATLRRLGDQFGHPNPLEHDLKYLLETGEYADAALVFTTGDSGVNSNSERAVGSCCEYGFRLELPCHKAILSARSPFFRNLIQRRTRSGEEHTERALHIPTRIVLDETVIPKRYAKVLLHAIYLDTVDLGLIIRGSGSTSTGSLGEAEALTCNGVRSRPTPLEEAMELYQIGRFLELDIVSQGCEDIILELLTIESLPGVLRWASEGHGSSWVLRQARHLLNEEFVQVSHSPVLFQLDKEHLVQALSSHFLQASELDVLVAVLKWGEHKLVRTMQDREPNVVSQTAHSVTRKGIKKRDLSDVELREVLSELLPLVRMDHVIPSDSEPLSQAIKRGLVSNPPSHMIGSDQRGGERINAWVRTWQHGQHSGLFVRPRLFMPYYEEIKVLVGEEQVVSEAGDPVRLRRGRFMRDIPDTLYMVHERPNPSVDVLSHNSLPAPDAATMSAMVKREAKLRQSATCQRAVALPLSSITEINRQIRLRVVREFNLPDQVASLLDNASCYQVEDEEELVIMGMVGGGGEGNGPRTGRSSGGVARRRRRSPGLPHQVPHLHQPAAPTVPLPAVVTEGSHHHLHLHHHHPSTPHLHHTYPAQWCGGEQLMPDVTMATASLDHLSLSPSQPQTSRLPSGEGGLELDLGDGPVAPPIPTSRRLTPPPPPHRFI
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- -
- 90% Identity
- -
- 80% Identity
- -