Basic Information

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 2.5e-19 9.1e-15 56.0 0.0 5 71 7 68 3 72 0.87

2 2 0.00092 33 6.1 0.1 29 73 93 145 75 148 0.83

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	2.5e-19	9.1e-15	56.0	0.0	5	71	7	68	3	72	0.87
2	2	0.00092	33	6.1	0.1	29	73	93	145	75	148	0.83

Coding Sequence: ATGTCTCTTGACAGAAGACGTTTCGAGTGCTCAGCCTTACCAAAAGGATGGCAAAGAGAAGAAGTTACCCGCAAAACTGGTCTCTCTGCAGGAAAAGTAGATGTTTCTTATTATAGCCCTGAAGGGGAGAAAATTGTAAATAAATCACAACTTGTGCGAGCTACTTGTGATATGATCGATCTGACAGCCTTTGACTTCCAGTCAGGACAATTTAATAGTTTTTTAAGGAGACCCAAAAAACAACGCACCCCTTCGATGTTTGAATACAGTCGAAATACAAGGAATGACGCTTCCTTAGTGCCTCCCATAAGACAAACAGCCTCTATATTTAAACAGCCAGTCACTGTTTACAAGATGCAAGAAAGTAAAGTGAAAACAGACTTCAAACATGGTCCCCAGGAAAAACCCAGACAGTTGTTTTGGGAGAAGAGGCTGGAAGGCCTGAAGGCGGTGAACACGGAAGGCGAAGTGCTCGAAGCCGTGGAGCTGGGCGGCGCCGTGCGGGCCGCCGGCCCCCGGGTGTCCGACGACACGTGCCTCCGGTCTCTGGCCACGGCCCTCCACCTGTCTCCTCAACCCATCACCGGTCAGCACCCTCACAAGGGTGCTCTCGACCGCAACCCCGCCGTCTTCCTCAATCCTGACCAGCCTCTTGTACAGACGATGGTGATCTCAGACGAAGACATAAGGAAGCAAGAAGAACGGGTCACTCTGGCCAGAAAGAAGCTGCAGGACGCTCTTCGTCACTTGTCCTGA
Protein Sequence: MSLDRRRFECSALPKGWQREEVTRKTGLSAGKVDVSYYSPEGEKIVNKSQLVRATCDMIDLTAFDFQSGQFNSFLRRPKKQRTPSMFEYSRNTRNDASLVPPIRQTASIFKQPVTVYKMQESKVKTDFKHGPQEKPRQLFWEKRLEGLKAVNTEGEVLEAVELGGAVRAAGPRVSDDTCLRSLATALHLSPQPITGQHPHKGALDRNPAVFLNPDQPLVQTMVISDEDIRKQEERVTLARKKLQDALRHLS

Sequence clustering based on sequence similarity using MMseqs2