Basic Information

Transcription Factor Domain

TF Family: LRRFIP
Domain: LRRFIP domain
PFAM: PF09738
TF Group: Unclassified Structure
Description: LRRFIP1 is a transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'- AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA [1]. LRRFIP2 may function as activator of the canonical Wnt signalling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin [2].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 5.2e-42 1.9e-37 131.2 19.9 128 300 9 173 2 173 0.86

2 2 0.018 6.7e+02 1.3 7.5 115 170 183 238 170 247 0.67

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	5.2e-42	1.9e-37	131.2	19.9	128	300	9	173	2	173	0.86
2	2	0.018	6.7e+02	1.3	7.5	115	170	183	238	170	247	0.67

Coding Sequence: ATGGAGCATCTCATAGTGATAGTAATGAAAGTGGAAGAGAAGCAAAGAAAGAAAAAGGCTGAAAGGGAGCAGAGAGAGAAGTGTCGCGAGGTGGAGCTGTTAAAGCGAGACCTGAACAAGTACAAGCGAGACCTCCAGTTGACGACGGCAGCGCTCGAGGAGAGAGACCTGCTCATTCAGGAGCAAGGGCTGGTAATAGTGGGTGGTGATTCTGAGTCATCAGGAGACGAGAAGGACGACGGTGTCCAGAAGCAGAAGAAGGCGCTCGTGTCCACTGACATGGCCGACCTCCTCAACTCCGTAGGCAAAGGATCGCTGGATGTTAGATTAAAGAAACTGGCCGCCGAAAGAAACGACTTAACCGATGAATTACGACATGTCAAGCTGGAGTTAGAGGAAGAAAAAGCGAAAGTGCGAGCTGGAACATCAGCAGACTTAGAAGAAATACAGAAAGAAGTAAATAAACAATTAGGAGATTACAAGTTTAAACTTCAAAAGGCAGAGCAAGGAAACGCTACTCTCCAGACCACTGTTACCAGGCTTGAAAGTCAAGTGTTGAGGTATAAAACTCTTTCTGAAACTTTAGAGAAAACTGAAGAACAGCTTAAGACTGAGAGAAGAAAACTTTTGAAGGAGCTGAGAGAATCACAAGACAGGGTCGAAGAATTGGAAATCGCCCATTCTCATTTAACGAAGAGACTGGACAAGTTGAAGAACGCCAAGTCGGCCTTGTTTAAAGATTTGTAG
Protein Sequence: MEHLIVIVMKVEEKQRKKKAEREQREKCREVELLKRDLNKYKRDLQLTTAALEERDLLIQEQGLVIVGGDSESSGDEKDDGVQKQKKALVSTDMADLLNSVGKGSLDVRLKKLAAERNDLTDELRHVKLELEEEKAKVRAGTSADLEEIQKEVNKQLGDYKFKLQKAEQGNATLQTTVTRLESQVLRYKTLSETLEKTEEQLKTERRKLLKELRESQDRVEELEIAHSHLTKRLDKLKNAKSALFKDL

Sequence clustering based on sequence similarity using MMseqs2