Basic Information

Transcription Factor Domain

TF Family: zf-LITAF-like
Domain: zf-LITAF-like domain
PFAM: PF10601
TF Group: Zinc-Coordinating Group
Description: Members of this family display a conserved zinc ribbon structure [3] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 2.9e-23 7.8e-20 71.5 13.4 2 69 96 167 95 168 0.86

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	2.9e-23	7.8e-20	71.5	13.4	2	69	96	167	95	168	0.86

Coding Sequence: ATGACGAGCCATCAAGGGCCCAGTGTTGCAGCAGCAGCGCCTACTGCGCCAGAAGATCTTCCGCCTCCTTACTCCGCCGTGATCGGGAATCCTCAATACGGTTTTGTGGCTGGTGGAGTAGATCCAGGTGCATATCCACAACCGAAGCAGTTTACAGCGCCGGGAGTTTATCCTCACCCGACGATAACGGTGACTAATACGCAGCCTCTCGCTGGGAACATACCACCTCCTCCACCCGGGCCGAATATGCCCGTCGGTATAGTTCTGCCGCTCGCTGTCGGCACGGAGCCCACCACAATCAACTGCTTCAACTGCGGTAAAACAGTCACCACGAGAGTCAACTACACCACCGCCTGGCACACACATTTAGTGGCTGGATCTATTTGCGTTGTTACCATGGTTTGTTCACTGTGCTGCCTTGGCCTGATCCCATACTGCTTTGATACATTCAAGGATGCTGAACACTACTGCCCCAACTGCAACACATTTATTGGTAAAAGCAACAAATGTTAA
Protein Sequence: MTSHQGPSVAAAAPTAPEDLPPPYSAVIGNPQYGFVAGGVDPGAYPQPKQFTAPGVYPHPTITVTNTQPLAGNIPPPPPGPNMPVGIVLPLAVGTEPTTINCFNCGKTVTTRVNYTTAWHTHLVAGSICVVTMVCSLCCLGLIPYCFDTFKDAEHYCPNCNTFIGKSNKC

Sequence clustering based on sequence similarity using MMseqs2