Basic Information

Gene Symbol
-
Assembly
GCA_963082805.1
Location
OY720164.1:21622084-21623695[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 0.037 3.7 9.3 1.7 2 23 158 180 157 180 0.93
2 10 5.5e-05 0.0055 18.2 0.6 1 23 186 208 186 208 0.98
3 10 0.24 24 6.8 0.9 1 23 214 236 214 236 0.94
4 10 6.6e-06 0.00066 21.1 2.0 1 23 242 264 242 264 0.97
5 10 5.1e-06 0.00051 21.5 1.3 1 23 273 295 273 295 0.98
6 10 4.9e-08 4.9e-06 27.8 0.6 1 23 301 323 301 323 0.99
7 10 0.00022 0.022 16.3 0.7 1 23 329 351 329 351 0.96
8 10 4.9e-05 0.0049 18.4 3.3 1 23 357 379 357 379 0.98
9 10 3.6e-06 0.00036 21.9 2.5 1 23 385 407 385 407 0.98
10 10 0.00021 0.021 16.4 5.8 1 23 413 436 413 436 0.98

Sequence Information

Coding Sequence
ATGGGGGCGCGGTGCCGTTTGTGTGCTGAAAGTTATGACGATTTGGTGGATGCGTTGGACGAGGCAGAACTGCCTTCCAAGATCCTTCAGTTTTTTCGGGTGAAGATTGTTGCCGAAGATAGATTACCCACCACAATATGTCGAAGATGTTACGATGCCATTAACGCCACTTGGGAATTTAACGAACAGATACAGAAAGCCCAGGAATTGCTTGTAATAGAAGAAGCTAACAAAATTGTAATCGAAGAACAAACCAAGAAATCTGTAGCAATGGTAGAATGTGTATTGTCAGATTCTGTAACAGAACAGCCAAAACGAAAAATGAAGACTAAGATTCGAAGAATTAAGAAAAGGGAATCTGTAAGTTCTGATTCAGAAGGTTTATTATCTGGTGCCAGTGATGCAGAATGGCATGATGACGGGAGTATAACATTACGCCGTTGTTTAGATGGTTGGGATACTTACCCATGGACATGTTGCGATTGTCAGCAGAACCTGTCTACCGCGGACGAACTTCGAGATCATCATTCATTAGTACATGGACAATCAGCAAAATATGTTTGCGCCGAGTGTCCAAAAATGTACACAAAATACAGTACTTTTATAAGTCACGTCCGCAGTCATCGAGAGCAATTACGTTTTTGCTGCGATATTTGTGGAAAATGGTATGGGACTAGCCGTGCTCAGGAACAACATCGAGCTTCACATTGTGACCAGCGTCCTCACAGTTGCACAACATGTGGGAAGAGATTTCGAGTGCAATCGTCTTTATTGGTTCATGCAAGGTCTCATTTACCTGCGGAATTGAAGAATAAGCATCAGTGCGATCAGTGTCCGAAACGATTTGGGACTAAACCTAATCTTATGGCGCATAAAAGAATCCATTCGGGTATTCGAGACTTCACATGTGATCAATGTGGAAAAAGTTTTGTGCAAAAAGGTAATTTAGACAATCATATGTTAACTCATACAGTGGCCAGACCTTTTACGTGTCTTTCTTGTGGGAAGGCATTTAAAACGGCAGTTCGCTTGCGGAAACACAGCTCGGTACATTCAGGATTAAAACCTCATCAGTGTGATGTTTGTGGACGGCAGTTTCGAGAGCGGGGTACTCTTAAAGAACATCATCGAATTCACACCGGTGCCATGCCATTTACATGTGAATATTGTGGAAAGTCGTTCCGATTTAAAGGAGTGTTAACTACTCATCGACGCCAGCACACAGGGGAACGGCCTTATTCCTGCCTAGAGTGTCAGCATCATTTCACTAATTGGCCTAATTATAATAAGCACATGAAAAGGCGACACGGTATTAATACAAGTGTTACAGTACGTAAGCCGCAATCAATTCCACCAACTGGCATGCCTCAAAGGAATCCTCCAGGAACTGTTCTAGCTCCGCCGCAACCAGCTACTGTCACGATGTTATCAGCCGTACCACCAACAAGTGTGGGAATTCctgataattttcctgaaactcCTCCTCCCTTTTATCCTGTTCTTAATTTATACAATCTTCCCGAAGAATTACTTCAACAACGTGTGTGA
Protein Sequence
MGARCRLCAESYDDLVDALDEAELPSKILQFFRVKIVAEDRLPTTICRRCYDAINATWEFNEQIQKAQELLVIEEANKIVIEEQTKKSVAMVECVLSDSVTEQPKRKMKTKIRRIKKRESVSSDSEGLLSGASDAEWHDDGSITLRRCLDGWDTYPWTCCDCQQNLSTADELRDHHSLVHGQSAKYVCAECPKMYTKYSTFISHVRSHREQLRFCCDICGKWYGTSRAQEQHRASHCDQRPHSCTTCGKRFRVQSSLLVHARSHLPAELKNKHQCDQCPKRFGTKPNLMAHKRIHSGIRDFTCDQCGKSFVQKGNLDNHMLTHTVARPFTCLSCGKAFKTAVRLRKHSSVHSGLKPHQCDVCGRQFRERGTLKEHHRIHTGAMPFTCEYCGKSFRFKGVLTTHRRQHTGERPYSCLECQHHFTNWPNYNKHMKRRHGINTSVTVRKPQSIPPTGMPQRNPPGTVLAPPQPATVTMLSAVPPTSVGIPDNFPETPPPFYPVLNLYNLPEELLQQRV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2