Basic Information

Insect: Hemicrepidius niger
Gene Symbol: pax2-a
Assembly: GCA_963082805.1
Location: OY720162.1:34105526-34131656[-]

Transcription Factor Domain

TF Family: PAX
Domain: PAX domain
PFAM: PF00292
TF Group: Helix-turn-helix
Description: The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 4.7e-70 1.3e-66 223.4 0.3 2 125 7 137 6 137 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	4.7e-70	1.3e-66	223.4	0.3	2	125	7	137	6	137	0.97

Sequence Information

Coding Sequence: ATGCGCCTTAGAAAGCGTCATGGCGGTGTCAATCAATTAGGTGGAGTTTTTGTTAATGGTAGACCACTTCCTGATGTTGTTCGACAAAGGATAGTTGAACTTGCCCATAATGGAGTACGACCATGCGACATTTCGAGACAACTTCGGGTGTCGCATGGATGTGTATCTAAAATTCTCTCAagTTTTCCAATGTTCTGTTGCAGATATTATGAAACGGGTAGCTTTAAGGCCGGTGTAATCGGTGGATCGAAACCAAAAGTAGCGACACCTCCTGTAGTGGACGCAATCGCCAACTACAAAAGGGAAAATCCCACCATGTTCGCATGGGAAATCCGGGACAGACTTCTAGCCGAAGGAATATGTTCTCAAGACAACGTACCTAGTGTTTCATCAATAAATAGGATTGTAAGAAATAAAGCAGCAGAAAAAGCCAAGACCGTACACCAACAATCGCTCAGTGGCGGAGGTAGTGTAACAAGTACGGGGAGCGGCGGGCCCGTTTCCGTAATAGCCCATGCACCTGCAACGCAACTTTCAGAACCAAGAACTGGGGCCTACAGTATCAATGGTATACTGGGTCTTCAGCACGATCCTAACGGAAATAGTATAAAAAGAAAACGAATTGACGATCACGATGAAAATAGAGATATTAACGGACATCCGGAAGATGACCTCAAAAGACAAAGATCGCAATACAATGGAGATCAGCTATATTCAAATCTTTGGTCAAGTAAATGGAGTATCAAAGAAGAACATAAGCTTCTCTCGGAATTGGGAGCTGCAGGTGGTACCTCAGGTCAAACGAGCTATTACGATGGACATGGAGGATTCCCCGGTGTGGGTCCTGTAAGTTCCGCTACCGATCTTTACGATACCATCAGCACCATGAGTCAAGCAACCTCGCAAAACCTTTATACACCACCACTAGGAGGTACATTAGGATCCTCTTTAACGCCGTTAGCCCCAATTACTATGCACGAGATGAAAATAGAAACCTCTAGGATACTCGATCCGGCCCTGTCACCCTATCACAATACAGCTGAGAATAGCTCGCCGTACAGTGGCGTAGTTGGGCTAGGGGCAGCTGTAGACGGGGCATCCCCCGGGCTGCCGCTGGCTGTACCAGCGGAACCAAATAGCCAACCAACATCTCACACCGGATCACCGGATCCTACGGCCCTTACTGTCTTACAACCATCAAACGGCGCTTCACAACATTATTCAACCATGTTGCCCAGTTTTGGCTACTCGACAGGAAGCGGCACAGTGGTTTCCGGGACGGACTATGCATATAGTACAGCCTATAGTCAATATGGAGCGGCCTATGGAAGTTACGGATATGGAAGCGCCTCCAGCGGGTTGCTGAATTCTCCATACTACTACAGCACCAGTGAGGGCCCCATTATAAGTTCAGTAGCGCACGTTACCGGACAATCCAATAACACAGAACAGAGCAGCCGCTCCCCCTTAGCGGCAACCAGAGCCAACTCATTGGCTTCAGCAAATTCTCCCACTGAAAGTGGCAGTGCGTGCCTGAAAAGCGAAGTTCTGTTCAACGATGATTTAAATCTCGGATAA
Protein Sequence: MRLRKRHGGVNQLGGVFVNGRPLPDVVRQRIVELAHNGVRPCDISRQLRVSHGCVSKILSSFPMFCCRYYETGSFKAGVIGGSKPKVATPPVVDAIANYKRENPTMFAWEIRDRLLAEGICSQDNVPSVSSINRIVRNKAAEKAKTVHQQSLSGGGSVTSTGSGGPVSVIAHAPATQLSEPRTGAYSINGILGLQHDPNGNSIKRKRIDDHDENRDINGHPEDDLKRQRSQYNGDQLYSNLWSSKWSIKEEHKLLSELGAAGGTSGQTSYYDGHGGFPGVGPVSSATDLYDTISTMSQATSQNLYTPPLGGTLGSSLTPLAPITMHEMKIETSRILDPALSPYHNTAENSSPYSGVVGLGAAVDGASPGLPLAVPAEPNSQPTSHTGSPDPTALTVLQPSNGASQHYSTMLPSFGYSTGSGTVVSGTDYAYSTAYSQYGAAYGSYGYGSASSGLLNSPYYYSTSEGPIISSVAHVTGQSNNTEQSSRSPLAATRANSLASANSPTESGSACLKSEVLFNDDLNLG

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00870523;
90% Identity: iTF_00151760; iTF_00949796; iTF_00950804; iTF_01293613; iTF_01291508; iTF_00269746; iTF_00927590; iTF_00272470; iTF_00271068; iTF_00268191;
80% Identity: -