Basic Information

Transcription Factor Domain

TF Family: BTB
Domain: zf-C2H2|ZBTB
PFAM: PF00651
TF Group: Zinc-Coordinating Group
Description: The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 0.92 4.7e+02 1.9 0.1 79 108 91 123 77 125 0.74

2 3 4.1e-18 2.1e-15 57.7 0.2 10 109 173 272 164 273 0.92

3 3 0.0059 3 8.9 0.2 77 109 272 304 267 305 0.90

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	0.92	4.7e+02	1.9	0.1	79	108	91	123	77	125	0.74
2	3	4.1e-18	2.1e-15	57.7	0.2	10	109	173	272	164	273	0.92
3	3	0.0059	3	8.9	0.2	77	109	272	304	267	305	0.90

Coding Sequence: ATGGATATGGATATAAAGGAGCACAGTGTTATTCAGGGGCATCAGATGTGCCAGACCAAAGATGCTAATTGGTTGTGTCTAGACAATATTTACATGAAATTCCATAGACCAAATATGTACGACATTGGTGGCACCAGCATTGATGATGTTGCAGATTATTGGTTCCTAATGCAGACAGAACAAGTGGGCAAGGTGTTTTTACTACATATATTCATCATGAATCGCCACGAAAGTACATTTAATGTCATGATCAGCGCCAACAACGAACTaacatttaacaaaaaacataattttgcaTATTTAACAGCACATCTGGAGAAAAttggttttaaaaatgtaaAGGAAATGTGCCAAAACTACCTAATCACATACAGTTTTATGGATTTGGACGTGGAGTCTTTAAAACATTACAAACTATATATACCCATATCATTTAATAACAGTGACATAGTCACTTCTGTTGTGGACAGTATGGCACCATTTCATGACTTTGGAGCATTACTGAAAGACCCAGTGGGGGCAGATTTCACAATAGAATCTTCGGATGGGACTAAATTTAGAGTGCATAAGATACTACTCACGTCTCTATGTGATGTGTTTAAGGCAATGTTAAAGGAGGACACTGCTGAGAGTCTaaatggttatgtaaagttagTTGATGTGAGTAAAGAGGACTTGAGCTGTATTGTTGAGTACATTTACACAGGTACTATAAAAGATAAAGAAAACACCAATTTCTTTAGTCTCCTCATATTAGCTGATAGGTATGACCTGAAAGGTTTAAAGGAATTGTCTGAATATATCCTCTCTAATCAGTTGTCTTCAGACAATGTTTTAGAAATTTTAGCCattgctgatttatataattccCAATGTTTAAAAACTGCATCaatgaaatttttaaaacaaaacccAGCTGCAATACACAGCAGCATGTTCCAAGAATTGAAGAGCATAGAGCTAGTGCAGGAACTTTGCAAATATTTGACAcctcaataa
Protein Sequence: MDMDIKEHSVIQGHQMCQTKDANWLCLDNIYMKFHRPNMYDIGGTSIDDVADYWFLMQTEQVGKVFLLHIFIMNRHESTFNVMISANNELTFNKKHNFAYLTAHLEKIGFKNVKEMCQNYLITYSFMDLDVESLKHYKLYIPISFNNSDIVTSVVDSMAPFHDFGALLKDPVGADFTIESSDGTKFRVHKILLTSLCDVFKAMLKEDTAESLNGYVKLVDVSKEDLSCIVEYIYTGTIKDKENTNFFSLLILADRYDLKGLKELSEYILSNQLSSDNVLEILAIADLYNSQCLKTASMKFLKQNPAAIHSSMFQELKSIELVQELCKYLTPQ

Sequence clustering based on sequence similarity using MMseqs2