Basic Information

Transcription Factor Domain

TF Family: Runt
Domain: Runt domain
PFAM: PF00853
TF Group: Beta-Scaffold Factors
Description: The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 2.4e-12 7.2e-09 35.1 0.2 103 129 3 29 1 29 0.94

2 2 1e-17 3e-14 52.5 0.1 93 129 59 95 57 95 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	2.4e-12	7.2e-09	35.1	0.2	103	129	3	29	1	29	0.94
2	2	1e-17	3e-14	52.5	0.1	93	129	59	95	57	95	0.97

Coding Sequence: ATGCTGGCGACGTCCCCCCCTCAAGTGGCGACGTACCAGAAGGCCATCAAGGTGACGGTGGATGGTCCTCGAGAGCCGAGGTCGAAGACCAGGCACCATGGATTCCATCCCTTCCACTTTGGACCACGGTTCCCGCCTGACCCCCTGATGGGGTCACTACCTTTTAAGTTGTCagGTAAATCGTTTACCCTGACGATAATGCTGGCGACGTCCCCCCCTCAAGTGGCGACGTACCAGAAGGCCATCAAGGTGACGGTGGATGGTCCTCGAGAGCCGAGGTCGAAGACCAGGCACCATGGATTCCATCCCTTCCACTTTGGACCACGGTTCCCGCCTGACCCCCTGATGGGGTCACTACCTTTTAAGTTGTCagGTATAGCTCACCAGCTGGCAGGTCTACCTGGTGGGGAATGGGGGGCTCTGGCGCGGCACTATCCTCCTCCCCTACTGCCCACCCCCGCGCACTTCACGCCACACGTTTTACCGCCGCATGCGCAGCCTCCACATGTAGCACCGCCACCACATGAGACTGATATAACATCAGATAATCCGATAACAATGCACGCGCACAGCACGACAAGTCCAGCAAATTCGCGTCCAAGCTCGCCACAGGATGACGACATCTCCGTCACAGCATCGAGCTCTCCACCGCCAGACGACCGTCCAGGAGCCTTCACATCCGTCACTAGATCAAGAAAACCGATGCAGCCGCTGCCAGCACCTTCCACACTCTTCCACAGCGCATTAGCAGCTCAATTATTCCTCAACTCCCCTCTACTTCCAACACCCCCCGCCTGGTTGTATTCCCAACTGTATGGGGGCTACGACTGGTGGCTCAGACCGCCTCCACCTCAAGAAGACTCCAACCATTCTAGCCCAGAAAGAGAAGACGAGAGCTCAACCACATCTGGAACTGGAAAAAAACGTCCCGCCTCCCCGGAGTGGTCAGAACAGGGGATGAGGACTCGGAGTAAGTCGCTGATAACGGCAGAAAGACGGCCCGTTGATGTGTGGCGTCCTTATTAG
Protein Sequence: MLATSPPQVATYQKAIKVTVDGPREPRSKTRHHGFHPFHFGPRFPPDPLMGSLPFKLSGKSFTLTIMLATSPPQVATYQKAIKVTVDGPREPRSKTRHHGFHPFHFGPRFPPDPLMGSLPFKLSGIAHQLAGLPGGEWGALARHYPPPLLPTPAHFTPHVLPPHAQPPHVAPPPHETDITSDNPITMHAHSTTSPANSRPSSPQDDDISVTASSSPPPDDRPGAFTSVTRSRKPMQPLPAPSTLFHSALAAQLFLNSPLLPTPPAWLYSQLYGGYDWWLRPPPPQEDSNHSSPEREDESSTTSGTGKKRPASPEWSEQGMRTRSKSLITAERRPVDVWRPY

Sequence clustering based on sequence similarity using MMseqs2