Hmel003184.1
Basic Information
- Insect
- Heliconius melpomene
- Gene Symbol
- Runx1
- Assembly
- None
- Location
- Hmel205001o:6417895-6424621[+]
Transcription Factor Domain
- TF Family
- Runt
- Domain
- Runt domain
- PFAM
- PF00853
- TF Group
- Beta-Scaffold Factors
- Description
- The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 2.8e-49 1.3e-45 154.2 0.0 7 94 33 119 27 137 0.94
Sequence Information
- Coding Sequence
- ATGCACTTGCCGTACGAGTCCAGGGGCCGTCGGCGCCGCGAGATGGCCGAGCTCGAGCCCTGGTGGCTCCAGTCCATCATCGACGAAACGCTGGGCGAACATCCTGACCTCGTACGGACCGGCAGCCCAGACTATATGTGCTCGCAGCTACCCCTACACTGGCGTTCGAACAAGACACTGCCAGGTGGTTTCAAGGTAGTGGCGTTGGGCGACGTGCTCGACGGTACCCAAGTCACCGTCAGAGCTGGCAACGACGAGAACTGCTCAGCAGAACTAAGGAATAATACAGCTGTTATGAAGAATAGAGTAGCCAAGTTCAATGATCTACGATTTGTGGGTAGAAGTGGTAGAGGAGATATGAAAAAACCTGAGCTCTTGTTCATACAATTACTACTGTGGAAACCGAAACCACAACCATCATCAAAAACTATAAATAGATATACTACCTGTCCTATTTAG
- Protein Sequence
- MHLPYESRGRRRREMAELEPWWLQSIIDETLGEHPDLVRTGSPDYMCSQLPLHWRSNKTLPGGFKVVALGDVLDGTQVTVRAGNDENCSAELRNNTAVMKNRVAKFNDLRFVGRSGRGDMKKPELLFIQLLLWKPKPQPSSKTINRYTTCPI
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00777781; iTF_00782416; iTF_00922678; iTF_01140717; iTF_00710808;
- 90% Identity
- iTF_00777781;
- 80% Identity
- -