Basic Information

Gene Symbol
-
Assembly
None
Location
Hel:1036409-1040842[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 8 0.033 2.5 8.4 0.1 2 23 315 337 314 337 0.91
2 8 0.04 3 8.1 5.4 2 23 358 379 357 379 0.97
3 8 0.2 16 5.9 0.2 1 23 383 405 383 405 0.96
4 8 0.0026 0.2 11.9 0.4 3 23 412 433 411 433 0.92
5 8 8.6 6.6e+02 0.8 0.3 2 10 440 448 439 450 0.93
6 8 0.0061 0.47 10.7 0.5 2 23 470 492 469 492 0.96
7 8 0.0003 0.023 14.8 5.4 1 23 498 520 498 520 0.98
8 8 0.00062 0.048 13.8 1.5 1 23 526 548 526 548 0.96

Sequence Information

Coding Sequence
ATGAATGAGGACAATAATATAATGATTTCTGAATATTTGTGCAGATGTAAATGTTGTTTAAATTATATAGAATTAAAAAGCTTGTGGGAAGTATATGAGAGTGATGGCGGTGATGAAATATACGGAAATATGGTTGTTGAGTGTTTTGGATTACCGTGGTTACCATCTGATGAACCAGAACATATTTGTGAGATGTGTATATTGAAATTACGAGAAGCACTTGATTTTAAAAGGAACATATTGGCTATTGAAGATATTCTATTAAATGAAATAGATATAAAAGAAGAAATGGACACCGAGTCTGATATAACATCATCCACAACACTAGTAAAATATGTTCCAATTAAAGAGGAATATGAGCATGTTGAATATTTGGAGTTTGAAGAAATGCCTGAAGAAAAACCACAACTAAAAATTATAACNGAATTAGCCAATATAAGTTCAGGTCCTTCAACACCAGGGGCCTCGAGTTCAGGGCCCCCCAGCCCTTTACGAAAATGGCCTAAAAAGAAGAAAAAACATGAATTAAGTAAATTCTATAAACAATATACTAAAGAAAACTTAGCAGAAGCGATAAGAGTGGTTAGAAATGGTGAAATGAGTTGCACATACGCAGCTAATAAGTATGGCGTACCGAAGAAAACTTTGACGGTTAAAGTTAACTCGTTTAGTGATGCCGATGGCGACGAATCCACCAATAAGCATTACAAATTAATAGAAGAAATCAAAGTACTCCTAACACATACAACAGCCGTGCCGTTCAAAACAAAAACGACTAGATATTATTGTTTCTACTGTTCTACTGAAGGCCCNTGNTTTGAAGANACTGACGAACTTAGNGAACATACTAAAACAAAACACGAACATGAATGGACTAAAATAGAATTATATATGAGACCACAATGGCTCAATGAAGTTATAAAAATGGATGTCCAAGATATACATTGTAAAATATGTCTAACAATGTTACCAGATTGGAATAATTTGTTCGTTCATTTGGCAGAAATACATAATTTNGAGTTTGATATGGCGTATACTAAAATTATACCTTATGGTCTAAGTGCTAATTTAAAATGCTTTTTGTGTNGGCAGAGTTTTCACAATTTCGGACATTTGGACAGTCATATGAATAATCATTATAGTAATTATATTTGTTATGAGTGTGGTGACACCTTTCTTTCAGTCAGTCGCTTGGACAAACATTTGAATGTACACAAAATTGGTAATTANCCTTGTGAATATTGTGATAAAGTATTCAAATTAGAAAAATATCGCTCAAAACATATAAGTTTAGTGCATATACAAGAAAATACAGTCAAATGTTTGTACTGTCCGGAAAAATTCCTAGGTATTTTCCAAAGGCATATACATGTAACAGAGAAACATAAAGAAAAAGTTAAATACATGACATGTGAATACTGCGGGAATAGTTATACATGGAAGCCATATTTTTTAGCGCATATGAAAAGAAGGCACGGTTCTGAGAAAAAATATAAATGTAAATATTGTGAGAAGTGTTTCTTAATGAAGTATGAATTGAAGAACCACATGGTGAGGCACACGGGAGAAAAGAATTTTGTATGTGGCTTATGTGGGCTAGGCTTTACTAGGATGGTCAGCTTGAAAAAGCATTGTCAGACCCACGAAGAAGAGATTATTGAGTAA
Protein Sequence
MNEDNNIMISEYLCRCKCCLNYIELKSLWEVYESDGGDEIYGNMVVECFGLPWLPSDEPEHICEMCILKLREALDFKRNILAIEDILLNEIDIKEEMDTESDITSSTTLVKYVPIKEEYEHVEYLEFEEMPEEKPQLKIITELANISSGPSTPGASSSGPPSPLRKWPKKKKKHELSKFYKQYTKENLAEAIRVVRNGEMSCTYAANKYGVPKKTLTVKVNSFSDADGDESTNKHYKLIEEIKVLLTHTTAVPFKTKTTRYYCFYCSTEGPXFEXTDELXEHTKTKHEHEWTKIELYMRPQWLNEVIKMDVQDIHCKICLTMLPDWNNLFVHLAEIHNXEFDMAYTKIIPYGLSANLKCFLCXQSFHNFGHLDSHMNNHYSNYICYECGDTFLSVSRLDKHLNVHKIGNXPCEYCDKVFKLEKYRSKHISLVHIQENTVKCLYCPEKFLGIFQRHIHVTEKHKEKVKYMTCEYCGNSYTWKPYFLAHMKRRHGSEKKYKCKYCEKCFLMKYELKNHMVRHTGEKNFVCGLCGLGFTRMVSLKKHCQTHEEEIIE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00457174;
90% Identity
iTF_00774435;
80% Identity
iTF_00777334;