Basic Information

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 0.45 3.4e+03 -1.2 0.0 30 38 59 67 32 69 0.69

2 2 1.4e-15 1.1e-11 45.3 0.0 4 75 99 163 96 165 0.89

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	0.45	3.4e+03	-1.2	0.0	30	38	59	67	32	69	0.69
2	2	1.4e-15	1.1e-11	45.3	0.0	4	75	99	163	96	165	0.89

Coding Sequence: ATGCCTTATGTAGAATATACGAGATCAGAAGAACAAAGTAAAACAGACACACAACAACCAAAAACGACTCAACAACAAAATGAGGAGCTTCGTCGTCAAAGAGCTGTTGCAAAAAAATCTACGAGTACTACAGTACCGCCGCCGCAACAAAATGTTGCTAATTTAGACAATGTCTGTAGTAGAGTTGTGtATTATACACCAAAAAGTGCTGTGAAACCTCTCAAAATGGTGCCACACACTTGTACCCCGAGATGTAAGAGGAAAGATGTGTTAGCGCTGAAAGATCTAAGGACTTACAATCCTTTGGCGAAACCGTTATTAAGTGGATGGGAGAGaCAAATAGTAAGATGGAAGTGCAACAAAGAAGTGATGTACAAAGCACCCTGCGGCAGACGGTTGCGGAACATGAAGGAACTCCATAAGTATTTGAGAGATATACAATCGGACATGGCGGTGGACTTATTTGATTTTTCCCCAGTCACGCATTGTTTAGCCgaatttgtattgaataacTGTTTTGTAGGAAAAAAGGATTTATCACACGGCAAAGAAAACGTACCAGTGCCCTGTGTGAACTACTATGATAATTCATTACCTGAATTCTGCTCATATAATACAGAGAGGACGCCCACTGCGGGGGTTCCCCTCAACTTGGACTCTGAGTTCTTGTGTGGATGCGATTGTGAGGATGACTGTGAGgataaaacaaaatgcgCCTGCTGGAAAATGACACTAGAAGGGGCAAAAACAATAGGCTTAGAGGGAAACAATGTTGGTTATTCGTACAAGAGACTGCCGGAACCATTGCCGTCTGGGATTTATGAATGTAACTCTAGGTGA
Protein Sequence: MPYVEYTRSEEQSKTDTQQPKTTQQQNEELRRQRAVAKKSTSTTVPPPQQNVANLDNVCSRVVYYTPKSAVKPLKMVPHTCTPRCKRKDVLALKDLRTYNPLAKPLLSGWERQIVRWKCNKEVMYKAPCGRRLRNMKELHKYLRDIQSDMAVDLFDFSPVTHCLAEFVLNNCFVGKKDLSHGKENVPVPCVNYYDNSLPEFCSYNTERTPTAGVPLNLDSEFLCGCDCEDDCEDKTKCACWKMTLEGAKTIGLEGNNVGYSYKRLPEPLPSGIYECNSR

Sequence clustering based on sequence similarity using MMseqs2