Basic Information

Gene Symbol
-
Assembly
GCA_905404275.1
Location
FR990106.1:23618636-23621925[-]

Transcription Factor Domain

TF Family
E2F
Domain
E2F_TDP domain
PFAM
PF02319
TF Group
Helix-turn-helix
Description
This family contains the transcription factor E2F and its dimerisation partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.043 5.1e+02 1.8 0.0 23 43 8 28 2 29 0.88
2 12 0.14 1.7e+03 0.2 0.0 25 44 73 92 64 93 0.87
3 12 0.024 2.9e+02 2.7 0.0 22 43 123 144 116 145 0.87
4 12 0.9 1.1e+04 -2.4 0.0 29 43 176 190 174 191 0.83
5 12 0.0078 93 4.2 0.0 22 44 222 244 213 245 0.87
6 12 0.32 3.8e+03 -1.0 0.0 22 41 285 304 278 307 0.80
7 12 0.028 3.4e+02 2.4 0.0 22 44 338 360 331 361 0.88
8 12 0.016 1.9e+02 3.2 0.0 22 43 391 412 384 413 0.87
9 12 0.32 3.8e+03 -1.0 0.0 22 41 454 473 447 476 0.80
10 12 0.042 5e+02 1.9 0.0 22 44 507 529 498 530 0.86
11 12 0.012 1.4e+02 3.7 0.0 22 44 560 582 551 583 0.87
12 12 0.27 3.2e+03 -0.7 0.0 22 41 623 642 614 645 0.78

Sequence Information

Coding Sequence
ATGATCTACAGCATCCTGAACCTCGTGCAGTTGTCCCAGGTGTTCGACGAGATCAACTCCATGTACAGGCGAGTGTGGAGCATAAATCCGTCGGACAGACGGCAAGGAGACGATCTACAGCATCCTGAACCTCGTGCAGTTGTCCCAGGCGAGTGTGGAGCATGGTTTCGTCGGACAAACGGCAAGGAGATGATCTACAGCATCCTGAACCTTGGGCAGTTGTCCCAGGTGTTCGACGAGATCAACTCCTTGTACAGGCGAGTGTGGAGCATAGTTTCGTCGGACAAACGGCAAGGAGATGATCTACAGCATCCTGAACCTCGTGCAGTTGTCCCAGACGGCAAGGAGACGATCTACAGCATCCTGAACCTCGTGCAGTTGTCCCAGGTGTTCGACGAGATCAACTCCGTGCACAGGCGAGTGTGGAGTATAGCTCTGTCCAACAGACGTCAAGGAGACGATGTACAGCCTCCTGAACCTCGTGCAGTTGTCCCAGGTGTTCGACGCGATCAACTCCAAGTACAGGTGTTCGACGAGATCAACTCCGTGCACAGGCGAGTGTGGAGTATAGCTCCGTCCGACAGACGGCAAGGAGGCGATCTACAGCATCCTGAACCTCGTGCAGTTGTCCCAGACGTCAAGGAGGCGATGTACAGCCTCCTGAACCTCGTGCAGTTGTCCCAGGTGTTCGACGCGATCAACTTCAAGTACAGGCGAGTGTGGAGCATAACTCCGTCGGACAAACGGCAAGGAGACGATTTACAGCATCCTGAACCTCGTGCAGTTGTCCCAGGCGAGTGTGGAGCATGTTTTCGTCGGACAAACGGCAAGGAGATGATCTACAGCATCCTGAACCTCGTGCAGTTGTCCCGGGTGTTCGACGAGATCAACTCCGTGTACAGGCGAGTGTGGAGCATGGTTTCGTCGGACAAACGGCAAGGAGATGATCTACAGCATCCTGAACCTTGGGCAGTTGTCCCAGACGGCAAGGAGACGATCTACAGCATCCTGAACCTCGTGCAGTTGTCCCAGGTGTTCGACGAGATCAACTCCGTGTACAGGCGAGTGTGGAGCATAGTTTCGTCGGACAAACGGCAAGGAGATGATCTACAGCATCCTGAACCTCGTGCAGTTGTCCCAGACGGCAAGGAGGCGATCTACAGCATCCTGAACCTCGTGCAGTTGTCCCAGGTGTTCGACGAGATCAACTTCGTGCACAGGCGAGTGTGGAGTATAGCTCTGTCCAACAGACGTCAAGGAGACGATGTACAGCCTCCTGAACCTCGTGCATTTGTCCCAGGCGAGTGTGGAGCATGTTTTCGTCGGACAAACGGCAAGGAGATGATCTACAGCATCCTGAACCTCGTGCAGTTGTCCCGGGTGTTCGACGAGATCAACTCCGTGTACAGGCGAGTGTGGAGCATGGTTTCGTCGGACAAACGGCAAGGAGATGATCTACAGCATCCTGAACCTTGGGCAGTTGTCCCAGACGTCAAGGAGACGATGTACAGCCTCCTGAACCTCGTGCAGTTGTCCCAGGTGTTCGACGCGATCAACTCCGTGTACAGGCGAGTGTGGAGCATAACTTCGTCGGACAAACGGCAAGGAGACGATTTACAGCATCCTGAACCTCGTGCAGTTGTCCCAGACGTCAAGGAGGCGATGTACAGCCTCCTGAACCTCGTGCAGTTGTCCCAGGTGTTCGACGCGATCAACTCCAAGTACAGGCGAGTGTGGAGCATAACTCCGTCGGACAAACGGCAAGGAGATGATCTACAGCATCCTGAACCTCGTGCAGTTGTCCCAGGCGAGTGTGGAGCATGTTTTCGTCGGACAAACGGCAAGAAGATGATCTACAGCATCCTGAACCTCGTGCAGTTGTCCCGGGTGTTCGACGAGATCAACTCCGTGTACAGGCGAGTGTGGAGCATGGTTTCGTCGGACAAACGGCAAGGAGATGATCTCCGGCATTCCTGA
Protein Sequence
MIYSILNLVQLSQVFDEINSMYRRVWSINPSDRRQGDDLQHPEPRAVVPGECGAWFRRTNGKEMIYSILNLGQLSQVFDEINSLYRRVWSIVSSDKRQGDDLQHPEPRAVVPDGKETIYSILNLVQLSQVFDEINSVHRRVWSIALSNRRQGDDVQPPEPRAVVPGVRRDQLQVQVFDEINSVHRRVWSIAPSDRRQGGDLQHPEPRAVVPDVKEAMYSLLNLVQLSQVFDAINFKYRRVWSITPSDKRQGDDLQHPEPRAVVPGECGACFRRTNGKEMIYSILNLVQLSRVFDEINSVYRRVWSMVSSDKRQGDDLQHPEPWAVVPDGKETIYSILNLVQLSQVFDEINSVYRRVWSIVSSDKRQGDDLQHPEPRAVVPDGKEAIYSILNLVQLSQVFDEINFVHRRVWSIALSNRRQGDDVQPPEPRAFVPGECGACFRRTNGKEMIYSILNLVQLSRVFDEINSVYRRVWSMVSSDKRQGDDLQHPEPWAVVPDVKETMYSLLNLVQLSQVFDAINSVYRRVWSITSSDKRQGDDLQHPEPRAVVPDVKEAMYSLLNLVQLSQVFDAINSKYRRVWSITPSDKRQGDDLQHPEPRAVVPGECGACFRRTNGKKMIYSILNLVQLSRVFDEINSVYRRVWSMVSSDKRQGDDLRHS*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-