Hnig012715.1
Basic Information
- Insect
- Hartigia nigra
- Gene Symbol
- foxo
- Assembly
- GCA_031001745.1
- Location
- JARPRG010000658.1:544482-544967[+]
Transcription Factor Domain
- TF Family
- Fork_head
- Domain
- Fork_head domain
- PFAM
- PF00250
- TF Group
- Helix-turn-helix
- Description
- The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 3.8e-15 3.6e-12 46.2 0.0 4 50 97 147 95 149 0.88
Sequence Information
- Coding Sequence
- ATGATGGACTCGGTACCGAGTTCAGGTTCCGGGTCGGGATCTGGTACCGGTACCGGTGCGGGAGTACCTTTTGACCTGGAGAACGGTTTTGAGCCACAGACCAGAGCAAGATCAAACACATGGCCTCTACCTAGACCAGAAGGCTATGTCGAGGGTAACGTTGTCGGTGGTGTTCCTGGTGGAAAGGAAGGCGTCGAGGGCGGTACACCACCTCAACAAGGTCCACTTACCCAGGGTGGCGGACTTCTTCCAGTGAAGAAGAATTCTTCACGAAGAAATGCCTGGGGCAATCTCAGCTATGCGGATTTGATCACGCAGGCCATCACCAGTGCTCCAGAGAAACGACTCACCCTGTCACAGATCTACGACTGGATGGTTCACAACGTACCTTATTTCAAGGACAAGGGAGACAGTAACAGCAGTGCTGGATGGAAGGTGAGTCTAATAGTTTATCCTCGATCTAAGTACTCGAAGGGTTTAAGGTGA
- Protein Sequence
- MMDSVPSSGSGSGSGTGTGAGVPFDLENGFEPQTRARSNTWPLPRPEGYVEGNVVGGVPGGKEGVEGGTPPQQGPLTQGGGLLPVKKNSSRRNAWGNLSYADLITQAITSAPEKRLTLSQIYDWMVHNVPYFKDKGDSNSSAGWKVSLIVYPRSKYSKGLR
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00253381;
- 90% Identity
- iTF_01130628; iTF_01198484; iTF_01199222; iTF_01474500; iTF_00253381; iTF_00251882; iTF_00298123; iTF_00292756; iTF_01475265; iTF_01472994; iTF_01473734; iTF_00296588; iTF_00295823; iTF_00295057; iTF_00297362; iTF_00291351; iTF_00293533; iTF_00252631; iTF_00254897; iTF_00254135; iTF_01537662; iTF_01394944;
- 80% Identity
- iTF_01198484; iTF_01199222;