Basic Information

Gene Symbol
MBD-R2
Assembly
GCA_951394225.1
Location
OX596280.1:40016558-40022143[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 2.2e-16 2.2e-12 48.3 0.0 6 69 414 475 409 484 0.86
2 2 1.7 1.7e+04 -2.6 0.0 41 58 1060 1077 1060 1090 0.84

Sequence Information

Coding Sequence
atgggTCGTAAGTGTAATGTATTAGATTGTCCATCAGATTCAAATCGAATCGAAGATAATGGTGTAACATTTCATAAAATGCCATTTCATCCAGATTTACGACCAAAATGGATTGAATTATGTCGCATTCCTAAAGAAAGGCAAACAAACAAAGTGATTTATGTATGTTCAAGACATTTTAGACGAACAGATTTCTGTAATTTCAAAGGTACAAAGTATATGCTTCGGCAGGGTGCTTTGCCCTCAGTATTTCCGTGGACTAAAAGCATTATAATACCACCTCAAACTAGTAAAACTACATTACcattggaagaagaaagtaATTCTATAGAAATTAAAACCGAAGAACCTGAAGATGAGAAGTCAAATAATGAAGAGTTAGGTGAAGTAGAAGTCAAAATAGAAATTCCTGAAGAAcctgaagaagaaaaagaaataccCTCGGAAAaacctaaaataaaaaaagatatttcTCCCCCGGTGAAGAAAGACGCATCTACAAGTAAAAAAGAACctgttgtaataataaataaagaaattaatgaaataccAATTCcagtagaaaataatatatctcCTGTTATAAGAACAGAACCTATAAATTTCTTACCAGGGACCAGAATAGAAGCTaatgattttaatgaaaagtggAATCCTGCAACTATTTTAGAAGTAGATTATGATGAAAACGAAGTATTTGTTGAATttgagaaacatttaaataaagcaAACGAGTGGATACCGATGGATAGTTCTAGATTACGACCATATCATCCGCCACCCACTAATATTGAAACATATGCTGTAGGAGAAAGAGTTCTTGCAGCTTGGATAAAAACAGTTAATAAATTTCCAGCTACGATTAAAAAAGTTATAGATTCTGAAACATATGAAGTCTTATTTGATGAtggatatttaaaaattatgaaatattccaaacttgcaaaaattaaagatgtgtCAGCTAGTCGGGGTCGTCTAAAACATTCATCGCCGTTATTTGATCCTGTAGTTGGCTCGAAAGAAGACAGGAGAGAAAGaaaacgaaaattaaatgttgCAGAATTGTTTGGTAAAGTTCCTATTgAAGATGATGTACAATCTCAAGAAGAATTTAGAAGTACAGGTTCATCTAGTCAAAATGAAGGTGAAGAATGGACGTGTCGCTGGTTAAACGGTGAACCAGTAGGAATTGAATCTGAACTAGAGGGACTAGATGGCCCAAGACGTTCAATTGTAGTCGCAGATCATCGTTTACCTCCAGGCTGGGAGAAACATTTAACTCAAAGGTTACATGGAAATAACGCAGGAAAATGGGACGCATTTATAATAGGTCCCAGCGGAAAAAGATTCTCTACTCGCGGACAAGTCAAGACATGGTTAGAAGATAATAAATTGGATTATAATGTAGAGAGATTTGATTTTTGTCTTCATTTAAATCGAGCCAAAAAATTAGGTTTATATGAAATTACTGATCCTGAGGCATTGGCTGCAGCAAAAGCTGCTCATCCTAAAGAACCATTCAAATATCACAAAAAATCATCAAAATCTCATGCTAATAAAATTTCAACTCCAAAAAGTGGTAGTAGTGTTAATTTACCTGTAACTCCAGAAATTCATGACCGTTTCCCTGAAGAGGAAGAGGAAGACACTTcacattatttgaaaattattcacGAAGATGGTAGTTATAAGTGTCCAATAGAAGGTTGCGGAAAGATTTTCCGAAAAGAAAACCTAGCACAGATGCATGTTAAACATTACCACCCAGAATCTGCTAAACTTTTAGGCTCCACTCCAAATGTTGCTGATTTAGCATATGCTAGAACAGTTGGAGAACATATTGATGATATAGTACCAAAAGCAAGAGGTGTTGGTTCTCCtcatgaaaaagaaaaaaatattagatctGAATCAACTCCAAAACCAAAATCTACTCTAAGAATTTTGCAACCCAAACTTCAATCAAAAATAGAGGAGGGGGAAATGAGAAAATCCCTTACGTCCCCACCCCTTCATCTATCAAAACATACCAAAGATTCAGAAATTATTAGATTACTGAACAGCGAACCAAAAACCAAAGGCATTGATTCTATTTTCGAAACAGTTCCTTCGAAAGCTCATGAGCATGTACCGATAAAAGAAGAACCTATTGAAAAATATCCAGACATCAAACTTAAAGATCTTTTGCATAAAGCAGAACCAATACCTCTATTTAAGAAAGAAGAACACCGATCAACCGGAATCAAAACTCTTCTTCCTGTAATAAGACATAATTTAGACGAAATTAAACAAGAAATGGAGGAACCTGAACCTGGTTTTCATGCACTTCCAAAAGCAGTTGAAAGGTTAAAACCAAGAAAGCGTCAATCTTCAGATAACAGTGAAGTAAAGAGAAGAAGATCTTTCAGATATGAGGACGAATTATCAGATTTCTACGAAGGGGATAGTCATTCTCAAGACTCCTTCAAGGAGAAGAAAGTTTTTGAAATGCAGCCCATTGCTCCAGTTGCCGAATCTCCGCAAGTTATTATTGAGGGAGGCGAAGTTATTCGTTTAGTACATATGAGGAGtgaagaaataataaattgtacatGTGGTATAACAGAAGAAGACGGTCTTATGATTCAGTGTGAGTTATGTTTATGCTGGCAACACGCTCAttgtaataatattcaaaaagaaaatgaagtacccgaaaaatatatttgttatatatgtaaaaatccTCCGAGAATGCGtgtttctaaaaaatatatacatgacCAAGATTGGTTAAAACAAGGAGTGCTCCCAACGGCAAATTATCATACGAAAGATGAAGAAGCTCTAAAAgagaaatttgaaaaattacgaaaatccCACGAACTTAGCGGATGTATAGttgaattaaatgaatatatacaCAATCTTAGAATTAAACTTAATATTGCAGAtaacAAAGATCACCCTAAACTTTATTTGTGGAGTAAAGCATGGAACAAGCCAGTTCCCAATGAAAACTTAAATGcaatgttaaattcaaaaacAGATCATAAACTAGATATTAAAgaggaaaatttgaattcaagcTTTTCCGGTTCGGATCATAGTTATATAAAAAGCAGCACATTCGGCGATGTTGCCCTTAAAAGTATGTTAGAACCACCAGTTGAAGAGATAAATCACGAAGACAcccaaaaaattaattctcAATCAGAACTGATTTCTATTCTTGAAGAAGGAACCAATCTTAAAACAGACATAAAAACAGAACCACCAGAATTCCCAAAAATTGATCTGAATACAATGATCGCTAATAATCTGGGTGATAAAACCGAATCAAAAGATGAAAATCTTCCAGAAGTTAATAAAGAAAATGCCTTAAGCGGAATTTTGAGTACTGGTTCTTTAGAGTTGGCGTTATCTCAAACTGATTTAGTTACTTCGTTCGCTCAGTTAAATGAAGTTGAAGCAACTACGACAGTTCCTCCTGTTCATATCCCTCAACCCGAAGCTGTTATAGATCCATCGGACTGTCGAATGAATCTAATTGAACACGTTTCTCATTTCCAAAGTTTGGTGGACGAAAGATTGAATTGCATTGAGGCGGAAATAAGTGAATTGGAGGACCAAGATTCAGATGATGATGAGGACGCATATCCAAAAATGAAACAGTCGTTACAAATGTTGATAAAAGATCTTGCAGCAATGCGGCACATAGCTGCTTTgagcaattaa
Protein Sequence
MGRKCNVLDCPSDSNRIEDNGVTFHKMPFHPDLRPKWIELCRIPKERQTNKVIYVCSRHFRRTDFCNFKGTKYMLRQGALPSVFPWTKSIIIPPQTSKTTLPLEEESNSIEIKTEEPEDEKSNNEELGEVEVKIEIPEEPEEEKEIPSEKPKIKKDISPPVKKDASTSKKEPVVIINKEINEIPIPVENNISPVIRTEPINFLPGTRIEANDFNEKWNPATILEVDYDENEVFVEFEKHLNKANEWIPMDSSRLRPYHPPPTNIETYAVGERVLAAWIKTVNKFPATIKKVIDSETYEVLFDDGYLKIMKYSKLAKIKDVSASRGRLKHSSPLFDPVVGSKEDRRERKRKLNVAELFGKVPIEDDVQSQEEFRSTGSSSQNEGEEWTCRWLNGEPVGIESELEGLDGPRRSIVVADHRLPPGWEKHLTQRLHGNNAGKWDAFIIGPSGKRFSTRGQVKTWLEDNKLDYNVERFDFCLHLNRAKKLGLYEITDPEALAAAKAAHPKEPFKYHKKSSKSHANKISTPKSGSSVNLPVTPEIHDRFPEEEEEDTSHYLKIIHEDGSYKCPIEGCGKIFRKENLAQMHVKHYHPESAKLLGSTPNVADLAYARTVGEHIDDIVPKARGVGSPHEKEKNIRSESTPKPKSTLRILQPKLQSKIEEGEMRKSLTSPPLHLSKHTKDSEIIRLLNSEPKTKGIDSIFETVPSKAHEHVPIKEEPIEKYPDIKLKDLLHKAEPIPLFKKEEHRSTGIKTLLPVIRHNLDEIKQEMEEPEPGFHALPKAVERLKPRKRQSSDNSEVKRRRSFRYEDELSDFYEGDSHSQDSFKEKKVFEMQPIAPVAESPQVIIEGGEVIRLVHMRSEEIINCTCGITEEDGLMIQCELCLCWQHAHCNNIQKENEVPEKYICYICKNPPRMRVSKKYIHDQDWLKQGVLPTANYHTKDEEALKEKFEKLRKSHELSGCIVELNEYIHNLRIKLNIADNKDHPKLYLWSKAWNKPVPNENLNAMLNSKTDHKLDIKEENLNSSFSGSDHSYIKSSTFGDVALKSMLEPPVEEINHEDTQKINSQSELISILEEGTNLKTDIKTEPPEFPKIDLNTMIANNLGDKTESKDENLPEVNKENALSGILSTGSLELALSQTDLVTSFAQLNEVEATTTVPPVHIPQPEAVIDPSDCRMNLIEHVSHFQSLVDERLNCIEAEISELEDQDSDDDEDAYPKMKQSLQMLIKDLAAMRHIAALSN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00768532;
90% Identity
iTF_01104538;
80% Identity
iTF_00768532;