Basic Information

Insect: Harmonia axyridis
Gene Symbol: topi
Assembly: None
Location: chr1:77556523-77559796[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 14 0.0025 0.22 12.6 2.1 2 21 126 145 125 146 0.94

2 14 5.9e-05 0.0052 17.7 2.3 1 20 171 190 171 193 0.94

3 14 0.0077 0.69 11.0 2.0 2 23 200 221 200 221 0.95

4 14 0.011 1 10.5 0.5 2 20 240 258 239 260 0.90

5 14 8e-05 0.0072 17.2 1.0 2 23 317 338 316 338 0.97

6 14 9.8 8.7e+02 1.2 0.1 1 12 344 355 344 364 0.84

7 14 0.0012 0.11 13.5 2.7 2 22 381 401 380 404 0.89

8 14 0.65 58 4.9 0.1 1 23 524 547 524 547 0.91

9 14 0.14 13 7.0 0.9 1 23 551 573 551 573 0.91

10 14 8.2e-07 7.3e-05 23.5 2.4 1 23 579 601 579 601 0.98

11 14 0.023 2 9.5 0.2 1 23 607 632 607 632 0.96

12 14 0.38 34 5.7 2.5 1 23 638 660 638 660 0.85

13 14 5.4e-05 0.0049 17.8 1.6 3 23 668 688 666 688 0.97

14 14 7.3e-07 6.5e-05 23.7 1.0 1 23 694 717 694 717 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	14	0.0025	0.22	12.6	2.1	2	21	126	145	125	146	0.94
2	14	5.9e-05	0.0052	17.7	2.3	1	20	171	190	171	193	0.94
3	14	0.0077	0.69	11.0	2.0	2	23	200	221	200	221	0.95
4	14	0.011	1	10.5	0.5	2	20	240	258	239	260	0.90
5	14	8e-05	0.0072	17.2	1.0	2	23	317	338	316	338	0.97
6	14	9.8	8.7e+02	1.2	0.1	1	12	344	355	344	364	0.84
7	14	0.0012	0.11	13.5	2.7	2	22	381	401	380	404	0.89
8	14	0.65	58	4.9	0.1	1	23	524	547	524	547	0.91
9	14	0.14	13	7.0	0.9	1	23	551	573	551	573	0.91
10	14	8.2e-07	7.3e-05	23.5	2.4	1	23	579	601	579	601	0.98
11	14	0.023	2	9.5	0.2	1	23	607	632	607	632	0.96
12	14	0.38	34	5.7	2.5	1	23	638	660	638	660	0.85
13	14	5.4e-05	0.0049	17.8	1.6	3	23	668	688	666	688	0.97
14	14	7.3e-07	6.5e-05	23.7	1.0	1	23	694	717	694	717	0.98

Sequence Information

Coding Sequence: ATGAGAAGCTCGGATAATCTTATTTTCAAAGTATACAAGATCAATGAGAATGGAATCGTTTCAGCAGTGGAATATGAACAAGATTTTTATACCCGCGAAGTACTATCGAAAAGACCCATTTCGTCCCAAGAACCCGCACCAAATTTGATTTGCGATCGGGAAAAGCTGAAATTGAACTTCAGTAACTTTGAATGCGAGGACGAGGATAATCCTCTTATTAGTTTTGTAAAAATTGAAAATATAAGCGATGTAAGTTTAATTGAAACCAGTGGATACTCTTGCCCAAAAAGTTTTATAGCTCGAGGTAAAAGAAGCGCTTCACCATGTTATTTGCATCATCAAATGAGGATTTCTTTGAATATTCCTACTATGATAAGATGTCAAAATTGCGAAACCAATTTCCCCACGAAATATCAATATCAAAGGCATCAATGTGAATTTAATGCAGAAAAAGTCGTTTTGAAAGCGAATGCTGATTTAAAAGATATAAACAAAGGAATGAGAATCAAGTATGATTGTGAGAGATGCGGAAAACAATTTGTAAGTAAAAATAATTTAGAAAGACATCAGATTTGTCACGAAAATTCAAAAGAAAACGTATGCGAGCATTGCAATAAACAGTTTGTTAGCGAAAATAGATTGAGAATTCATAAAGAAAATCACTGTAAAAAGGTAGGAGATATATCTAAGTTTTATCGTAGCGATGTTGCTGTTTGGAAATGCAAAAAATGTCATGAAGTATTTTCTTCTTTGAATTCTGCGAATACTCATGTGGAATCATGTAAGGAAGATTTATTTCAATATGATCAAAGTGATCCTAAAGATACTTTTGACGATGAAAAAAAAGAGAGTCCTAGTACTGTTTCACTATTTATAGTTAATGATGATTTGAATTCCAAGCTATTAGATGAAAGCCAAATTGAAAAAATTCTCACAGAAATTTTGTTGCAGTGTGAATTTTGTAACAGAACTTATGCCGATAAAAACTTACTTCTGTTACATCAAAGAAAACATTCTACTGCTAAAAATTATGAATGTGTTAACTGTAAAAGCAGCTTTGAGTCATATGCAGTTGCTGCTCAACATTGGCTGAAAATATGTTCGGAAACTTCCAACATGTTTTATCTGCCAAAATTAACTTATTGTGAATACTGTGATCGCACATTCAAGTCTCATGAATTGTTATATGCACATAAAATAAAGAAAAAACATTATACAGTGAAACTACATATGAATGATTCACATTCTAATAAAGATAATATGAGAGAGAAACAAATCGATAGTAGTGAAACCATTAATAAACTCATTGAAGATGTGTTAATTACACTGGACAGACCAATAGGTAAAATTTGCCAATTGACTAAACTCAATTACGATGATTCAAATAAAGAGAATATCGAAGTGGAAGCTCATTATACACAAAGGGAATTTAGTGATGTTCCCGAAGATTCTATGAATAACGAGAATTCAGATAAACCTGAAAAGAAAAAGAGGGGACGAAAACGAAAATGTTCCAAACCTGGAATAAGGAGCAAAAAGCTTCAAAGTCTGATAAATGAAGGATACAAGTACCAATGTGAACGTTGCCCACTTGTGTGGGATAATATTACCGATCTAGAGAAACACAGAGATGAAGAACATGCAGCAAGTTTTAGTTGTGAGGATTGTGGACAGATTTTACATAGTGCCAAAGCACTGCTTATCCATTGTCGGGCTCACAAGTGTCTGAAACCATATGTTTGTGATACTTGTGGCAGAAGCTATTCCCAAACATCTCATCTCTGGCAACACATGAGATTTCATCAAGGCATAAAACCCTTTGCATGTCCCCATGAGGGGTGTGAAGCTAGATACACTATCCGTCCAGATCTGAAAGATCATATAAGAAAAGTACACACTAGGGAGAGACCCTTTAAATGTGCAGTTTGTAATAAATGCTTCCTAACAGGTTCCGTTTATTACCAACATCGTTTAATCCATACCAACGATAGACGATATGGGTGTGATGTCTGCCATAAAAGATTTTTCAGAGCTGATGCTTTGAACAATCATAAAAGAATTCACACTGATGAACGTCCATATCCATGTACTGTGTGTGGAAGAGAATTCAGGCAGAAGGGAGATCGTAATAAACACATGCGTACTCAACACCCTGAAGCTGTTGTTCAGTGA
Protein Sequence: MRSSDNLIFKVYKINENGIVSAVEYEQDFYTREVLSKRPISSQEPAPNLICDREKLKLNFSNFECEDEDNPLISFVKIENISDVSLIETSGYSCPKSFIARGKRSASPCYLHHQMRISLNIPTMIRCQNCETNFPTKYQYQRHQCEFNAEKVVLKANADLKDINKGMRIKYDCERCGKQFVSKNNLERHQICHENSKENVCEHCNKQFVSENRLRIHKENHCKKVGDISKFYRSDVAVWKCKKCHEVFSSLNSANTHVESCKEDLFQYDQSDPKDTFDDEKKESPSTVSLFIVNDDLNSKLLDESQIEKILTEILLQCEFCNRTYADKNLLLLHQRKHSTAKNYECVNCKSSFESYAVAAQHWLKICSETSNMFYLPKLTYCEYCDRTFKSHELLYAHKIKKKHYTVKLHMNDSHSNKDNMREKQIDSSETINKLIEDVLITLDRPIGKICQLTKLNYDDSNKENIEVEAHYTQREFSDVPEDSMNNENSDKPEKKKRGRKRKCSKPGIRSKKLQSLINEGYKYQCERCPLVWDNITDLEKHRDEEHAASFSCEDCGQILHSAKALLIHCRAHKCLKPYVCDTCGRSYSQTSHLWQHMRFHQGIKPFACPHEGCEARYTIRPDLKDHIRKVHTRERPFKCAVCNKCFLTGSVYYQHRLIHTNDRRYGCDVCHKRFFRADALNNHKRIHTDERPYPCTVCGREFRQKGDRNKHMRTQHPEAVVQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00349527;
90% Identity: iTF_00130759; iTF_00020723;
80% Identity: -