Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.0018 1.7 8.3 1.0 21 48 95 122 86 124 0.84

2 9 0.0064 6.1 6.5 0.2 21 49 124 152 121 156 0.89

3 9 0.087 83 2.9 0.8 18 36 150 169 149 181 0.71

4 9 0.022 21 4.8 0.2 20 48 181 209 165 212 0.82

5 9 0.00018 0.18 11.5 1.5 21 48 211 238 206 239 0.89

6 9 0.0025 2.4 7.8 0.8 20 49 239 268 235 272 0.87

7 9 0.0015 1.4 8.6 0.2 21 49 269 297 266 302 0.87

8 9 0.36 3.4e+02 0.9 0.1 23 45 300 322 298 327 0.75

9 9 0.0045 4.3 7.0 0.1 21 48 327 354 323 356 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.0018	1.7	8.3	1.0	21	48	95	122	86	124	0.84
2	9	0.0064	6.1	6.5	0.2	21	49	124	152	121	156	0.89
3	9	0.087	83	2.9	0.8	18	36	150	169	149	181	0.71
4	9	0.022	21	4.8	0.2	20	48	181	209	165	212	0.82
5	9	0.00018	0.18	11.5	1.5	21	48	211	238	206	239	0.89
6	9	0.0025	2.4	7.8	0.8	20	49	239	268	235	272	0.87
7	9	0.0015	1.4	8.6	0.2	21	49	269	297	266	302	0.87
8	9	0.36	3.4e+02	0.9	0.1	23	45	300	322	298	327	0.75
9	9	0.0045	4.3	7.0	0.1	21	48	327	354	323	356	0.91

Coding Sequence: ATGGCTGAAGAAATTAATCCTCCttTTCAGTCAATTCTTATCAAAAGAGAGGAATTGGAGGAGATCTATTATGatGGGCATGTCCCTGTGGAAACAGAATTAGTCGTCCCTGAAGAAGATGGTCATGTTCCTGTGAAAGAAGAATTAATCATTCTTGATAAAGTACCCACGAATCTTATCAAAGAAGAGGAGGGATTAGATATTGATTAtgATCGGCTAGGTCAAGTTAAACAAGAAGAAGTGTTGCTTCGGGACGAAGGTTCCAAGGATAGTTCCCATACTGGTCAGAAGCCTCATCACTGTCCTTATTGCAACTATAAAGCCGTTCAGTCTTATCACATGAAAAGACATATAAGTGCCCAACATACAGGAGAGAAACCTCataaatgtcctcattgtgactaTAAAACTGTTCAggctgattatatgaaaaagcatataatggcccgtcacACAGGTGAGAAGCCACATCATTGTCCTTATTGCGACTATAAAGCTGTACGGGCAGATTACATGAAAAGTCACGTAAAGGCCCAtcatacaggtgagaagcctcataaATGTCCTCATTGCGACTATAAAGCTGTTCACTCTGATTATCTAAAAAAGCATATAATGGCCCATCAcacaggtgagaagcctcatcaatgtccctATTGCGACCATAGAGTTGTTCAATCTTATCAGCTAAAGAGGCATATAATGGCTCACCACACaagtgagaagcctcatcaatgtcctcattgcgATTATAAAGCTGTGCAGCCTTTTCATATGAAAAGACATATAATGGTTCATCACACAGGTGAGAAGCCTTataaatgtcctcattgtgactaCACCGCTGTTCAGtctgattatttgaaaaagcaTATAATGGCTCATCATTTAGGCGTTAAGCCTTATCACTGTCCTCTCTGTGACTATAAAGCTGTTCATtctgattatatgaaaaaacacATAATGGCCGCTCACACAGGTGAGAAGCCTtttcaatgtcctcattgtgattataagtCAGTACAGTCTGGGACtctgaaaaatcatataatagcCCGTCATAAAGGTGAATAG
Protein Sequence: MAEEINPPFQSILIKREELEEIYYDGHVPVETELVVPEEDGHVPVKEELIILDKVPTNLIKEEEGLDIDYDRLGQVKQEEVLLRDEGSKDSSHTGQKPHHCPYCNYKAVQSYHMKRHISAQHTGEKPHKCPHCDYKTVQADYMKKHIMARHTGEKPHHCPYCDYKAVRADYMKSHVKAHHTGEKPHKCPHCDYKAVHSDYLKKHIMAHHTGEKPHQCPYCDHRVVQSYQLKRHIMAHHTSEKPHQCPHCDYKAVQPFHMKRHIMVHHTGEKPYKCPHCDYTAVQSDYLKKHIMAHHLGVKPYHCPLCDYKAVHSDYMKKHIMAAHTGEKPFQCPHCDYKSVQSGTLKNHIIARHKGE

Sequence clustering based on sequence similarity using MMseqs2