Gvir017902.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Gymnocheta viridis
Gene Symbol
MBD-R2
Assembly
GCA_956483585.1
Location
OY101442.1:20451385-20455874[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 6e-23 5e-19 68.9 0.1 4 76 422 492 419 493 0.93
2 2 1.8 1.5e+04 -3.2 0.0 45 63 924 940 923 945 0.79

Sequence Information

Coding Sequence
ATGGGTCGCCGGTGTTGTATAGCCGGGTGTACATCAACTTCACGCTTGCCAGAACATCATGGTGTTACTTATCATTCATTTCCCGCTGATCAAAATGCACGCTCTATTTGGATACGCAATACCAAAATAAGCACCGATCGTCATTTAACCAAAAGTGTTTTAGTATGCTCCAGACACTTTCGTCGTGCTGATTTTCAACCACAACGTAGCGGTAAATATATGCTGAAGCAAAAAGTTTTCCCTACAGTATTTCCCTGGGGTAAAATTGATGCTGCACAAATTGAAGAGgatttggaatttttaaacTCCACTAGCACGGCAGCACCAACCAACTTGTTGACCACTTCCTCTGCGGTAGATGAAGATACAAAAGCTACTGTGGCGGCCACGGTAGCACAAATTATGGCGCAAACAGCTGAACTAAATGCTGCAGCAGGTATAAAAGTAGAGAAACCGGATGGTACCTCTGAAGAACAACCATTGAATGATACTACTGTAACAGTTGCTTCCACTCCGCCGAATGTTAAATTTGAGCCTGTAACTTCCTTTAACCCTGGTGCCCGATTGGAGGCTCAAGATTTTGACAGTGCCTGGCATATGGCACGTATCGTGGAGGTTGACAATGATGACCGTGAGGTTctcattaaatttgaaaagaatgctaaaaataaatccAATATTGCCGGCACCGAAGAATGGATACCTATGAATTCTTCCCGCCTACGCCAACGTATATCCACTaaaccaattttaaattttgaattggaGGAAAAATGTTTAGCACGTTGGTCGGGACCTCGCAAATTTCCCGGAACCGTTAAAAAAATTCTACCAAATGAtgtttatgaaattttgttcgatgaTGGTTATGTTAAGAATGTTCGGGCTATTCACATGAATAAAGTGCAGCCAATTACTGTAGCGGAACCTGAAATTGTAGAAAGTGTACCAGTGGAAATACCCGCTGTTGTGCCAGATGCTCCTACTAGTAGCGAACCATGTGTTGCGGCACTTCCGGTAACACCCGTATCTTCCGCTGTAAAAAGGCCATCTTCTGGACAGAATTCTGGTTCTCACCCCAAAAAACGCACTCATAATGGTCCAAGAAAAGATTGGCCGTTGTTGGACTTGTCAAAATTGGATTTggCATCACTCAATCTTCCCGGTATTCCCAAAGATGGCGAATGGACTTGTCACTGGGTTAATGATCAACCCATAGGACGTGAAGGTTATTTAGTGGTTGGGGAACATCGTAAACCTACAGTAATAGTAGAAGACTGGCGTTTACCTCCCGGTTGGGTCAAACATATGTATCAACGATCCAATGTTTTAGGAAAATGGGATGTTATTTTAGTTACGCCGAATGGCAAACGCTTTAGATCCAAAGCAGATCTTAAAACCTATTTAGAAGAGCAGGGCCAAGTATACAACCCTGACATATATGACTTTAGCATACATCGGCGTAGAGCCAAAGATATCAATTGCTATGTACATACACCCGACTATGTACCACAGCAGCCGGTTAAATCAAAATCGTCATTAAATACTTCTCTAGATACCAGTTTGGAAACCAAATCCTCGCCTGTTGTAGGAACATTGCCGAGTGCAGTCGATTCTCCCTATATGGATACTCCTGTAGCGGAACCCTTACCACCCATAGAATTGTTAACTTCTTCAAGTAGTTTGGCCGCAGAAGATAAAAGTGTGACGCAAGTAGAGGCTGAAGTACCGAAACAACTTTTAGAATCGGCTGAAGTTAGTTCAACGCCTACTCCCACTTCCACACCTACAGTTGGTTTGAAAGAAGAGGCTGTAGTCTCATCGGATTGTGCTACACCCACTCCTATTTCAACAACAGAAACATCAATGAATGCTTTAGAAGAATCACTAAAAGTTGAGGATGGTTTTGCTCTTATTGGTGGCCTAAAGGTACAAATAATCGATAATCTATTTCGTTGTCCTCAGGAGGGCTGTTCAAAAAATTTCCGCAAAGAAAATCATTTGCAAATTCACGTCAAGCATTATCACCGCAATTTAGTTAAATTACTAGGTTCGTGCCCTAAAATGTTAGAATTGGCGGAAAAGCGCACTCATCCGGCGGATAACGAAGCGGCTGAACCGGTGCCTAAAAATCAAATTCCGAATCAACAGTTTTTTGCTAAACTACACCAGCAAGACCTCGAGCAAACCCGAGCTCACCGCAGGAGTACTGGTGTTCTAAAGAGCACTATCGATATGACTTTAGCAGAAGTCAAAACAGAACAAATAGACGAAACTACTATTAAAGTTGAGGAAAATGCCCTAAATATGGATAACTCACAAAATGATACTTCTGTTAATAACTCAACCGCTAATTCTAGTGCACTTATGGAGAGTTCTTTTGCCTCCATCAGTGCAGCCGATGATTCTATAGTCACAGAAACGTGTTTAACAGAACCGCCTGCATATAAAAGGTCTAGATTTTCACTCAACAAGAAATCATCTGGGTCAAGGAAGAGTAATCGCCAAAGAACTACTAGGAAATATCTTACAGCAGCGGGTGTTGTGGCATCTGCAAACAGTTTGCCAGTAGCTGTAGATTCTGGTTTTAGTGGTGTGGCTGAATTCGAAGAGACTCGTCACTCTTTCAATGCTACACCAGAAATCAAAGATACTAAAAAACGTAAAACTGTTCTACCCTCTAACACTCCTCTCAGCAGTGTTGATTCTCCCATAACAGCCGATTCCGGTTCAAATTCTTTCCAACCCCAAAATTCCACAGAAAATGACACAATTAATCAACCTCCACAATATATCAAAGAAAATggtgaattaattaaaatcgtgCATATGCGCCAAGAAGAAATCATCAACTGTTTATGTGGCTATTGTGAAGAAGACGGTTTAATGCTACAATGTGAACTTTGTCTCTGTTGGCAGCACGGCTTGTGTAATGGCATCGACAAAGTCTCAGATGTACCCGATAAATATGTCTGCTATATATGCCGCAATCCCCAAAGAATTCGTGAATCGTTACGCTTCAAACATGATCAGGACTGGTTATATGAGGGCAAATTGCCGGCTGCAAACTATCACGCATCCAACCCTAATCAGTTAAACAAAAGATCGGAATATCTTAAACGTTCTCATATTCTAACTGGAAATCTTTTAGAATTGAAAAACTACATGCACTCGTTAAGAGTTAAAATCAATATAGCGAACAATAAATGTCACCCTAAACTTTATCTCTGGGCTAAGAAATGGGATGAAGACTCAGGAGCcgatataaaaaaggaaattaagcCCGAAAGTGGcgatgaaaacaaaacaatcaatGCTAACATACATGCAACACccacaaagaaaattaaatctgAACCGAGTACTCCAGCGAGGCCTGTGCCAAATATACCACAACCAGAAGCCCCTATTGATCCCATAGAATGTCAACAGCGACTAATGGAGCATATTAAAATACAACAGGATTTAGTTATAGGACGCTTGGATGACATAGAAGCGGCCATAGAtgTTTTAGAAAGTGAGGATGACTTGCCTGATTTGCGTGAAGAAGATTTAGGTGCCACTAAAGATGCTTTAGCCGCTTTTATAAAAGAGTTGGAGACGGTTAAACAAATTGCCAAGCTAAATAGTTTAGAACATATTAAATTGACATACAAAAACGTCATTCCTCCAGTTAAATAG
Protein Sequence
MGRRCCIAGCTSTSRLPEHHGVTYHSFPADQNARSIWIRNTKISTDRHLTKSVLVCSRHFRRADFQPQRSGKYMLKQKVFPTVFPWGKIDAAQIEEDLEFLNSTSTAAPTNLLTTSSAVDEDTKATVAATVAQIMAQTAELNAAAGIKVEKPDGTSEEQPLNDTTVTVASTPPNVKFEPVTSFNPGARLEAQDFDSAWHMARIVEVDNDDREVLIKFEKNAKNKSNIAGTEEWIPMNSSRLRQRISTKPILNFELEEKCLARWSGPRKFPGTVKKILPNDVYEILFDDGYVKNVRAIHMNKVQPITVAEPEIVESVPVEIPAVVPDAPTSSEPCVAALPVTPVSSAVKRPSSGQNSGSHPKKRTHNGPRKDWPLLDLSKLDLASLNLPGIPKDGEWTCHWVNDQPIGREGYLVVGEHRKPTVIVEDWRLPPGWVKHMYQRSNVLGKWDVILVTPNGKRFRSKADLKTYLEEQGQVYNPDIYDFSIHRRRAKDINCYVHTPDYVPQQPVKSKSSLNTSLDTSLETKSSPVVGTLPSAVDSPYMDTPVAEPLPPIELLTSSSSLAAEDKSVTQVEAEVPKQLLESAEVSSTPTPTSTPTVGLKEEAVVSSDCATPTPISTTETSMNALEESLKVEDGFALIGGLKVQIIDNLFRCPQEGCSKNFRKENHLQIHVKHYHRNLVKLLGSCPKMLELAEKRTHPADNEAAEPVPKNQIPNQQFFAKLHQQDLEQTRAHRRSTGVLKSTIDMTLAEVKTEQIDETTIKVEENALNMDNSQNDTSVNNSTANSSALMESSFASISAADDSIVTETCLTEPPAYKRSRFSLNKKSSGSRKSNRQRTTRKYLTAAGVVASANSLPVAVDSGFSGVAEFEETRHSFNATPEIKDTKKRKTVLPSNTPLSSVDSPITADSGSNSFQPQNSTENDTINQPPQYIKENGELIKIVHMRQEEIINCLCGYCEEDGLMLQCELCLCWQHGLCNGIDKVSDVPDKYVCYICRNPQRIRESLRFKHDQDWLYEGKLPAANYHASNPNQLNKRSEYLKRSHILTGNLLELKNYMHSLRVKINIANNKCHPKLYLWAKKWDEDSGADIKKEIKPESGDENKTINANIHATPTKKIKSEPSTPARPVPNIPQPEAPIDPIECQQRLMEHIKIQQDLVIGRLDDIEAAIDVLESEDDLPDLREEDLGATKDALAAFIKELETVKQIAKLNSLEHIKLTYKNVIPPVK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01174299;
90% Identity
iTF_00760143;
80% Identity
iTF_00760143;