Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.01 57 4.6 0.3 25 44 72 91 55 96 0.82

2 7 0.0015 8.6 7.2 0.1 21 44 96 119 91 124 0.90

3 7 0.0029 17 6.3 0.0 21 45 124 148 119 151 0.89

4 7 0.0016 9.1 7.1 0.1 21 43 152 174 150 183 0.87

5 7 0.12 6.8e+02 1.1 0.1 21 52 180 211 176 211 0.83

6 7 0.00059 3.4 8.5 0.1 22 48 209 235 200 240 0.83

7 7 0.021 1.2e+02 3.5 0.1 21 50 236 265 231 268 0.85

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.01	57	4.6	0.3	25	44	72	91	55	96	0.82
2	7	0.0015	8.6	7.2	0.1	21	44	96	119	91	124	0.90
3	7	0.0029	17	6.3	0.0	21	45	124	148	119	151	0.89
4	7	0.0016	9.1	7.1	0.1	21	43	152	174	150	183	0.87
5	7	0.12	6.8e+02	1.1	0.1	21	52	180	211	176	211	0.83
6	7	0.00059	3.4	8.5	0.1	22	48	209	235	200	240	0.83
7	7	0.021	1.2e+02	3.5	0.1	21	50	236	265	231	268	0.85

Coding Sequence: ATGACGTCGCTTGAAGATAGCAAGTTCCTAAAAGGTGCGAGAACAACAAGTGACATTGAAAAGTTAGAAGTTGAAGTAGATGTTTATGCCGGCGTTACCTACACTGACACTGAAAAAACAGAATTCACTTCTGCTAAAAATATTAACTCATCACAGACATGGGGAAGTGCAGAAGGATCATCGAATGCGGGGACAGAACAAATATCAAATAAATTCGCTTGTAAAATATGTTTGAGAAGTTTTAGTCAGCAAGTTAATTTAGTAAGGCATGAAAGAATACATACCGGGGAAAGACCTTATCGATGTGAAATTTGTTTGAAATCTTTTTCCCAACAGTCCAATTTGTGGAAACATATTAGAACTCATACGGGAGAGAAGCCTTTCTCCTGTAATGTTTGTGGCAAATCATTCACACAACAAGCAAATCTTGTGAAACATGTTCGGATTCATACTGGTGAACGACCATTTATTTGCCCTGTATGTAAAAAAGCCTTTGCCCAACGTTCAAACATGTTGAAACACGAGAAGACTCACACTGGAGAGCGCCCTTTTCATTGTACTTTTTGCTCAAAAACCTTTGCCCAGCAGTCTTATTTGGATAAACATGAACGTACACATACAGGTGCTAAGCCATATTCTTGTAAGATCTGTCACAAAGCATTTACACAGCAAAGCAACATGACTAAACATATATCCATTCATTTGAAGGAGAAGCCTTTTCCTTGTAAGTTTTGCCAGAAATCATACACTCAAAAATCCAATTTAGAGAAACACGGAAAGAAATGCCAATTTAAAAAGGAAAATACTAGAAATCTAGAGGTCAAAAAGGAGTCAGAGGTAGAGAATGATAATGAGTCTCTTCTAGAAAGTGACTCTTCAGAATAA
Protein Sequence: MTSLEDSKFLKGARTTSDIEKLEVEVDVYAGVTYTDTEKTEFTSAKNINSSQTWGSAEGSSNAGTEQISNKFACKICLRSFSQQVNLVRHERIHTGERPYRCEICLKSFSQQSNLWKHIRTHTGEKPFSCNVCGKSFTQQANLVKHVRIHTGERPFICPVCKKAFAQRSNMLKHEKTHTGERPFHCTFCSKTFAQQSYLDKHERTHTGAKPYSCKICHKAFTQQSNMTKHISIHLKEKPFPCKFCQKSYTQKSNLEKHGKKCQFKKENTRNLEVKKESEVENDNESLLESDSSE

Sequence clustering based on sequence similarity using MMseqs2