Basic Information

Gene Symbol
MBD2
Assembly
GCA_026546565.1
Location
JANSWN010028485.1:2886-4501[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 2.9e-18 1.2e-14 53.9 0.1 1 72 5 95 5 100 0.83

Sequence Information

Coding Sequence
ATGAACATAACGATTGAAAGAAAAAAGACTGATTGCGTTGCTTTGCCAAAAGGATGGCAACGCGAAGAAGTTCTACGAAAATCCGGCCTGTCTGCGGGAAAAGTAGATGTATTTTATTACAGCAGAGGTGTTCGCACGGATGTATCTTTGGTTCCACCGATACGACAAACTGCATCAATATTCAAACAACCAGTAACCGTGTACAAAATGCTAGACAGCAAAGTGAAGCAAGACTTGAAACATGGCAATCAAGAAAAGCCCAAGCAGCTGTTCTGGGAAAAACGCTTAGAGGGATTACGAGCATGCGATATGGATGGAATTGAATTTGGTCCCATCGAACTACCCAAAGGTTTGAAACCCGTTGGTCCAAATGTTGATGAGGGAACATTATTGCAATCGGTTGCCACTGCCTTGCATGTTACTTCACAACCGGTAACGGGCCAGAATACCACTAAAACAGTACTAACCGCAAATCCGGGTGTATTTTTGAATCCTGATCAACCGCTAATGCACTCAATGATTGTCAGCGAAGATGATATACGACGACAAGAAGATCGGGTTGGTAGCGCTCGTAGAAAACTACAAGAATTTTTGAAAGCATAA
Protein Sequence
MNITIERKKTDCVALPKGWQREEVLRKSGLSAGKVDVFYYSRGVRTDVSLVPPIRQTASIFKQPVTVYKMLDSKVKQDLKHGNQEKPKQLFWEKRLEGLRACDMDGIEFGPIELPKGLKPVGPNVDEGTLLQSVATALHVTSQPVTGQNTTKTVLTANPGVFLNPDQPLMHSMIVSEDDIRRQEDRVGSARRKLQEFLKA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00203550;
90% Identity
-
80% Identity
-