Basic Information

Transcription Factor Domain

TF Family: Fork_head
Domain: Fork_head domain
PFAM: PF00250
TF Group: Helix-turn-helix
Description: The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 1.5e-16 9.6e-14 50.7 0.1 32 83 25 73 22 78 0.89

2 2 9 5.8e+03 -3.1 0.0 10 38 198 226 193 233 0.70

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	1.5e-16	9.6e-14	50.7	0.1	32	83	25	73	22	78	0.89
2	2	9	5.8e+03	-3.1	0.0	10	38	198	226	193	233	0.70

Coding Sequence: ATGAATTCGTCTGTGTGCTCATTTCTAACTCATGGTACAAATGCTTCGTGCTTCGAAAGAGAAAAGCGCGGAGTATGTGATCGTTTCCCTTACTACAAATCAAACGATGACCGTTGGAAAAACTCTGTACGTCATAATCTTTCGATAAATCCACATTTTCGTAAAGGAATCAAAGCCCCACAAGGTGCTGGTCATCTGTGGACAATTTCCAGCGGCGACTCTGCCGAAAATGTATTAGCCTGGGAGCATAAAAAACAACGATTAGATTTATTCTTTAAAATGGAATCAATTAATCGTGAGCGTctcttacaacatcaacagcaacagcaacagcaacagcagcaacaacagcaacaacaacaacaacagcaagagaaacataatcaaaattgtgaacataagcaagcaagttgtcaagaagatcaatcagtcggttgtggcatatacgatgaagcagctatagcagcagctgccatacaacaggatatgatgcagtgtcaacaagagcaacaTCTCGACTCTCTTTCTAATCCTCTACAGCATAGTGGCGGCATAGCGTTAGATTCTCCGGGCACTCATGCCATTCAATCGTTAACCTATAACGATCTGTTAAGTGATGAAGAGTTACGTAAAACAGCGGGCCAAATATTAAACGGTATACATCGCGAAGTAGAAGTACAATCTGTAAATCAATCTATTATCGGCACTTATCACGATGTTCTATTAGATAATGAAGATTATTTAAATCCAATTCATAAAGATGTGGCCGTTCACGAAAGTGGTCTGCAACAATCACTGTCATCGGCTTCGTCCGCTGCCTCTCAGTGCGCAACTAACAGTAACCACAGCTCGACCCAATATTATATAACTGAAATTGACGGTATGGATTTGGGCGGGCCGATGTCACAACACAACGATAACAACACACCCACAACTGAAGAATCGGACGCAGCGTTATTTAGCGACGAATTCAATTTAAATTACTTCAGTTACGCAGCAGTTAATGACAGCATTTCTTGA
Protein Sequence: MNSSVCSFLTHGTNASCFEREKRGVCDRFPYYKSNDDRWKNSVRHNLSINPHFRKGIKAPQGAGHLWTISSGDSAENVLAWEHKKQRLDLFFKMESINRERLLQHQQQQQQQQQQQQQQQQQQQEKHNQNCEHKQASCQEDQSVGCGIYDEAAIAAAAIQQDMMQCQQEQHLDSLSNPLQHSGGIALDSPGTHAIQSLTYNDLLSDEELRKTAGQILNGIHREVEVQSVNQSIIGTYHDVLLDNEDYLNPIHKDVAVHESGLQQSLSSASSAASQCATNSNHSSTQYYITEIDGMDLGGPMSQHNDNNTPTTEESDAALFSDEFNLNYFSYAAVNDSIS

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00746531; iTF_00749513; iTF_00747289; iTF_00750272; iTF_00748040;
90% Identity: iTF_00749513;
80% Identity: -