Basic Information

Gene Symbol
-
Assembly
GCA_949316385.1
Location
OX438681.1:6482431-6498268[+]

Transcription Factor Domain

TF Family
PAX
Domain
PAX domain
PFAM
PF00292
TF Group
Helix-turn-helix
Description
The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 0.00062 1.4 9.9 0.0 18 65 288 335 283 370 0.84
2 3 0.00016 0.37 11.8 0.0 17 86 400 469 389 488 0.85
3 3 0.00042 0.96 10.5 0.0 18 88 520 590 513 605 0.87

Sequence Information

Coding Sequence
ATGGCTCCTGTTAACCAGGAAGAATTAAAGgtgTGCAGAGTTTGCCTTGCTTTAGATGTCAAAATGTACAATATGAAAGATTTTAGATTGAGTGAAATGTTCCAAAATATCACTGGAATAACGGCTACCGAGAAAAAGGGCAGTATACTACAGCGGGTTTGTTGGGAGTGCGCTGCACGCCTTACAGCGGCTGCAGCCTTCAGAGAAAAAGCGCTACTCAGCGATGCATTGCTGAAAGACCAAGTACACATCAAAGAAAGTGACATtgcattattaaaacaaaattacaattcTCTAAAATCACCTCTATCTGTTAAAAAAGCAGTTACTTCTTATGACATTGAATGCGAACATACTATCTCtgcaaataaagaaataaaatcattacgcAATGATGAGACAGATGTCAAAGACAGAAAACACAAAATAAGAGTTGATAATGAAGAAGAAAAAGAGATGGAATTTGAACAGTACGAGGCCTGGATAGATGTTCCTGTGAAAACTGAGATAGAATCTGATCCTATAGCCGATAATAATATGCGATTTCAAGATCGAAAGAGCTATACATTTTCGGAACAAACACATTTCAATGATGCGTCTCCCACTGAAAATATTGAAGATGAAATGACAAATACTGGAAGGGAAGATACCACAAAAAAATTCCCGTACATAAATGATGCTGGAAACATCATTTTAGTAGATAAAGAGAGAAAAATTAAGCCTGATGTAATCGGTAAGATAGTGGATGAGGCCGCGAGTGATGAAGACGTAATAAGTACAGCAGGATCTGGCAGTAAGTGTCAGCAAGCGATGACCAGTGAGGCTGAGGCTTCGAATAAAAGAGTAAGGCGTATATACAAGCTTAACGACaggataaaagaaaaaataattgagTTGAAGAATAACGGTGTCTCAGTCTCCGCCATAGCTAAAGAAACTGGGCTGTCGacaTCATCTATAAGCTGTTGGTGGAGACGCTACCGTATAAACAGTAACATGTACCGAAGATCTATTACTCCAGGGGACCGGGGTTTTTCAAGACAGAATTACTATCTCAACGTTGCTGAACCTGGAAAAGAGATGGAAGCTTGTCCTGCAATAGTGAAGCAGAGATTACATGAGGCTGGTCTTGAACACATACTCATGAAGAAGCCTGAAAGAACTGTAAATGTGGGACTGAAAACTAGTACGCGTAAAGAGCTTcatgaagatttaaaaaagcgAATTATTGCACTGAAGCAGGAAGGAGTGTCTAATAGTCGGATAGCGTATCTTTTAAATACTGCAcgaaACACAGTTCAAAAGTGGTGGAGTCGCTGGTGCAATGAAGGGCATATGCAAAACCACAAGCAACCTGGAAGGAAGAGAAAAACAACGCCTCAAGAAGACCAACTCTTAATAGAGCGGGTGTCTCAGGAACAAACTGTGCATACGCCCACCCTGGCTAAGGAATTTGGCATTTCTTTgaagtgtCTTACAAATAGGCTAAAAGAGGCAGGATTTAAAAACAAGACAAGGGAAGCTTACGTACCCTTGAAAGCGGGCCGGAGTCATAAggTCGATGAGGAAATCAAACAACAGATAATATCGATGAAACTAAACGGCGTTTCAGTCACCGACATTGCTAACCAATTTCGAGTGCCGCGTACCACAATCTATCAATGGTGGCAGCGCTGGTGTAAAgaaaacaacataaaaataacaaacgaTAATAACACAAGTTACACAACCACCACAGCTGAACAAGACAAGAACTTAGCAGAATATACTAGCGTCGAAAGACTTGTACAAACGCCATCAATAACGTCCTCACAGAAGTCATTATGGCAGAAAGTGCCTGACGATGTGGAATTGCAACCTTAA
Protein Sequence
MAPVNQEELKVCRVCLALDVKMYNMKDFRLSEMFQNITGITATEKKGSILQRVCWECAARLTAAAAFREKALLSDALLKDQVHIKESDIALLKQNYNSLKSPLSVKKAVTSYDIECEHTISANKEIKSLRNDETDVKDRKHKIRVDNEEEKEMEFEQYEAWIDVPVKTEIESDPIADNNMRFQDRKSYTFSEQTHFNDASPTENIEDEMTNTGREDTTKKFPYINDAGNIILVDKERKIKPDVIGKIVDEAASDEDVISTAGSGSKCQQAMTSEAEASNKRVRRIYKLNDRIKEKIIELKNNGVSVSAIAKETGLSTSSISCWWRRYRINSNMYRRSITPGDRGFSRQNYYLNVAEPGKEMEACPAIVKQRLHEAGLEHILMKKPERTVNVGLKTSTRKELHEDLKKRIIALKQEGVSNSRIAYLLNTARNTVQKWWSRWCNEGHMQNHKQPGRKRKTTPQEDQLLIERVSQEQTVHTPTLAKEFGISLKCLTNRLKEAGFKNKTREAYVPLKAGRSHKVDEEIKQQIISMKLNGVSVTDIANQFRVPRTTIYQWWQRWCKENNIKITNDNNTSYTTTTAEQDKNLAEYTSVERLVQTPSITSSQKSLWQKVPDDVELQP

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00924639;
90% Identity
-
80% Identity
-