Basic Information

Transcription Factor Domain

TF Family: BTB
Domain: zf-C2H2|ZBTB
PFAM: PF00651
TF Group: Zinc-Coordinating Group
Description: The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 4.2 2.2e+03 -0.0 0.2 20 69 65 120 51 137 0.61

2 3 3.9e-18 2.1e-15 58.0 0.3 9 109 174 274 166 275 0.89

3 3 0.0016 0.84 11.0 0.1 78 109 275 306 272 307 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	4.2	2.2e+03	-0.0	0.2	20	69	65	120	51	137	0.61
2	3	3.9e-18	2.1e-15	58.0	0.3	9	109	174	274	166	275	0.89
3	3	0.0016	0.84	11.0	0.1	78	109	275	306	272	307	0.91

Coding Sequence: ATGGCATTGATTTTGATGTTTCAGGAAAATAGTGTGATTCAGGGGCATCAAATGTGCCAGACTAAGGATGCCAGTTGGTTGTGTTTGGACAACATCTATATGAAGTTTCACAGACCCAACATATATGACATCGGGGGGACTAACATCGACCACATAGCAGATTACTGGTTCCTCATGCAGACTGAGCAAGTGGGCAAGGTGTTCCTGCTACATATTTTCATCATGAATCGACATGAAAGTACATTTACAGTGTTAATTAGTGCCAACAGTGAACTATCATATAACAAGAGACATAATTTTGCACACTTGTCAACGAACCTGGAAAAGTACTCTTTTAAAAATGTCGATGAAATGGTGCAAAACTATCTCACCACATACAGCTTCACAGATATAGATGTGGAGTccctaaaaaattataaactgtATATACCCATATCCTTCGACTACTTCGATCCAGACAACACCTCGGTCGATAGTAATATGCCATTTCATGATTTTGAAACATTGCTGAAAGATCCTGTGGGCGCCGATTTTACAATAGAATCGGCCGATGGTGAAAAGTTTAAAGTTCATAGAATACTACTTACTTCCTTGTGCGAAGTGTTTAAGGCAATGTTAAAAGAAGACACGGCTGAGAGTCAAAATGGTTATGTTAAACTCGTTGACGTGAGCAAGGAGGACCTCAGTTGCATAGTGGAATTCATCTATACTGGTACAGTTAAAGATATAGAGAACAATAATTTCTTTAGTCTGCTCATGTTAGCCGATAGATATGACCTAAAGGGTTTGAAGGAGCTAGCGGAGATTGTACTTTCGAATCAGTTGTCTTCTGAGAATGTTTTAGAAATTTTAGCTGTGGCAGACCTTTATAACTCTCAGCACTTAAAAACTGCCTCCATGAAGTTTTTGAAACAAAACCCAACGGCTATACACAGCAGTATGTTCAGTGAGCTAAAGAATGTAGAACTGGTGCAGGAGCTTTGTAAATTTATGACTCCACAATAG
Protein Sequence: MALILMFQENSVIQGHQMCQTKDASWLCLDNIYMKFHRPNIYDIGGTNIDHIADYWFLMQTEQVGKVFLLHIFIMNRHESTFTVLISANSELSYNKRHNFAHLSTNLEKYSFKNVDEMVQNYLTTYSFTDIDVESLKNYKLYIPISFDYFDPDNTSVDSNMPFHDFETLLKDPVGADFTIESADGEKFKVHRILLTSLCEVFKAMLKEDTAESQNGYVKLVDVSKEDLSCIVEFIYTGTVKDIENNNFFSLLMLADRYDLKGLKELAEIVLSNQLSSENVLEILAVADLYNSQHLKTASMKFLKQNPTAIHSSMFSELKNVELVQELCKFMTPQ*

Sequence clustering based on sequence similarity using MMseqs2