Basic Information

Gene Symbol
Bcl11a
Assembly
GCA_958496185.1
Location
OY292311.1:2622440-2633292[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 9.4e-05 0.0061 17.4 1.5 1 23 219 242 219 242 0.91
2 11 4e-05 0.0026 18.5 2.1 2 23 250 271 249 271 0.97
3 11 0.0026 0.17 12.8 0.1 1 23 275 298 275 298 0.97
4 11 0.2 13 6.9 0.4 1 16 302 317 302 318 0.94
5 11 1.8e-06 0.00012 22.8 2.3 3 23 343 364 341 364 0.96
6 11 0.0091 0.59 11.1 7.9 2 23 368 389 368 390 0.95
7 11 0.004 0.26 12.3 0.2 3 22 405 424 404 428 0.91
8 11 0.00017 0.011 16.6 0.1 2 23 437 459 436 459 0.91
9 11 0.0011 0.075 14.0 5.0 1 23 465 488 465 488 0.95
10 11 7.6e-05 0.005 17.7 1.0 2 23 498 519 497 519 0.97
11 11 0.00031 0.02 15.8 1.5 1 23 525 548 525 548 0.98

Sequence Information

Coding Sequence
ATGTATTCAGTAAAAgttgaaatgtataaaaaagatatttgtcGTGGATGTCTGAGTACGAACAGACAGACGGCACTAATAAAAAGGCATGTGGACTTGTTTTTTAGCTTATTAGGTGACCAGCAACAGTATTGCGATGCAAAAGTGTATCTATGCTGGGAATGCAGGGCTCTGCTGAAACGGACTCGCAAATTTCAAGACAGTATCCAGCATGCACAGTTTATACTGCAGCAGTCACTTTTTGCACTGGAGAACATGCCTCTAACAGGTCTATCGAATTTGTCAACAATTCAAAAAGATTTCTACGATGCTGTAATAGAGGATGAACAACCAAAAACAATACAGGAAAGTTTACAAGATGATGTCATagacaatttaataaaacaagagGTGGACGACATAGATGACGCATATGATGATTTCAAAACTGAAGATCCACCGGGAGTCATAGACAATATCGGTGTACCCGAGATAAAAAGTGAGAACATAAAGAAACACTCTATAAAAAGGTACGAGAGCAAAGCGCATGTGATCAAAAGTGATATAGATTTAAGCGATTCAAAAAAGTACTGGGTGAGAGTGTACTTGAGCGAGAAAGAGATAGAGGAGTTGTTAGAAAGGGACAATGTTAATAGCAGTTACAAAAAGAGGCCGTACAAGTGTGAGGAGTGTAACAAGGCTTACAAGAGGGAGGTAGATTATAAAAGGCACGTCACTTTTTCTCACCGTGATCAATCTGGCCCCCTCAAGTGTACAATGTGTAAAATAAGATTCACCTCATGGCAAGCGCTGGAGCATCATTGGCGACGGCACAACATCCACTACCGCTGCCTGCTGTGCGGCTGGTTGTCCCGCCGGCCCACAGCGCTCACAGCTCACAATAGGCGGGTGCACTCACTGGTGTACGTGTGCAACACATGCGACGCGAGGTGTCGGCGAGCCCACTCACTGGTGTACGTGTGCAACACATGTCGGACGCTGCGCGAGTTCAGCAACCACTACAAGGAAGCACACGAACGCATCATATGCGACCACTGCGGGAAGAGCTTCGTTAAAAAACGGACCCTGGAAAAGCATATAAAACGCAACCATCTGCCGGCCACGTGTCACACATGCGGCCGGACGTACGCCCACTACCACGTGCTCGAGAACCACTACAGGATGCACCATCCCGAGCTGATCCGAGGCGACACCCGTACCGAGCTCGCGTACTGCGTGGAGTGCGACAAACAGTTTCCCACAGTTTACAAGTACAGGAGACACCTCGCTACTGCCGCCAAGCACACACCGCCTAAACCGGTCAGGATCCCATGTCCGGATTGCGGCAAAGTTTTCGCGCGCAAAATTCGCATGACCAACCATTTTAAGGCGGTGCATATGAATAACACGAAGCACAGATGCGACATTTGCAATAAAACATTCTGTTCAGCGTATTCGGCGCGAACACACCGCCAGTACGTACACGAGAAGATACCCATGCCCAAGAATAAGATGTGCGACATATGTGGCAGGGGCTTCAGCACAAATCGCATCCTTACAAACCACCGGCGCACGCACACAGGGGAACGGCCGTACAAGTGCGCACACTGTCCCGCTACGTTCGCGCAACGGACGGCAATGAAGACCCACGAGAAGACACAACACAAAAATCTAGTCTATACTGTACCACAGTGA
Protein Sequence
MYSVKVEMYKKDICRGCLSTNRQTALIKRHVDLFFSLLGDQQQYCDAKVYLCWECRALLKRTRKFQDSIQHAQFILQQSLFALENMPLTGLSNLSTIQKDFYDAVIEDEQPKTIQESLQDDVIDNLIKQEVDDIDDAYDDFKTEDPPGVIDNIGVPEIKSENIKKHSIKRYESKAHVIKSDIDLSDSKKYWVRVYLSEKEIEELLERDNVNSSYKKRPYKCEECNKAYKREVDYKRHVTFSHRDQSGPLKCTMCKIRFTSWQALEHHWRRHNIHYRCLLCGWLSRRPTALTAHNRRVHSLVYVCNTCDARCRRAHSLVYVCNTCRTLREFSNHYKEAHERIICDHCGKSFVKKRTLEKHIKRNHLPATCHTCGRTYAHYHVLENHYRMHHPELIRGDTRTELAYCVECDKQFPTVYKYRRHLATAAKHTPPKPVRIPCPDCGKVFARKIRMTNHFKAVHMNNTKHRCDICNKTFCSAYSARTHRQYVHEKIPMPKNKMCDICGRGFSTNRILTNHRRTHTGERPYKCAHCPATFAQRTAMKTHEKTQHKNLVYTVPQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00008246;
90% Identity
-
80% Identity
-