Basic Information

Gene Symbol
MBD-R2_1
Assembly
GCA_963978555.1
Location
OZ021710.1:13729382-13735259[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 8.9e-17 9.2e-13 48.8 0.1 8 75 432 498 428 500 0.93

Sequence Information

Coding Sequence
atgggaCGAAAATGTAATGTTGAAAGCTGTCAATCTGATTCAAATCGTTCTCAAGATGTAGGAGTAACATTTCATAAGGTGCCTCCTCATTTGGATATAAGACCTAAGTGGCTATCGCTGTGTAGAATACCTGAAGATAAGAAATTGGTGAAAGTCCTTTATGTATGTTCTAGGCATTTCCTTCGAGCTGATTTTTGTAATTTCAAAGgtaaaaaatatatgttgaaGCAGGGTGTCTTACCAAGTGTGTTTCCATGGGATAAATCAAAACTGGACGCTATTAAAGCAGAATCAAAAAAAGATAAGCCAGTACATATAAAGGAAGAACCTCAGGATGATGGTAAAAGTAATTCAGATGACAAGCAAGAATTTGCAATTGATGgaattaaacaagaaattatagagaatgaaaattcaaatatgGAAACTGATGTGAAACCTGAGCCACAAGAAGAACCTGATGATAAGTCTACCCAAAATTCCAAATTACCATCATCAAATTCTACCTTTCtaaatttcacaataaattCGAGAGCTGAAGcattagattttaacaatgaatGGTTTCCAGCTAAAATAGTAGAAATTGATTATGAAGAAAATGAAGTCTTGATACATTTTGAGaattattcaagtaaatatGATGAATGGATATCTATGGATAGCTCAAGATTACGACCTTTGCAAAATGCAGATGAAAGTGCTGAAACTAGTGTAATTGATGATCCTGTTGCTGATATGGATCCAAATTCAATTATACATAATGCTGCTGAAAAACCAAATGAAATGGAAACTTTTGTGGTGGGGGAAAGGTGCCTTGCTACTTGGAGTAATTCTAAAAAGTTTCCTGCAACAGTTTCTAAAGTTTTGGAAAACAaTTCTTATGAAGTATTATTTGATGATGGgtttgtgaaaatttcaaaaggTAGTTCAATGACTAAAACTCAAGGTAAACCACTTCAATCTAGTCCACTTTTTGATCCCATAAAAAGTAGCAAACAGGAcagaagagagaaaaaaaggaAACATAATGTAGCTACTTTgtttagaaaaagacgtaaacTAGATCATTCGGAAGAGAAGCCTAAGAAAGTATCTACTACAGCAGTAACTAATGTGCCAACACAACTTCCACCTGAAGCAGAACTGCCCCCACTGCAAGAAATACCAATTGTACCAGCTACTCCAGTTGatattgaaaattggaaaccAAGCTGGTACAAAGGAAAACCAGTTGGAATAGAGGCAACACTTCAAACTCAAGATGGTCCAAAAGTGTCTTACATTGTCCCAGATCCTAGGATTCCTCCTGGGTGGAACAAACATATTTTAAGAAGAACAAAAGGCTGTGATGCTGGTAAATGGGATACAATTATTGTCagTCCTGAAAATAAACGATTTAGATCAAAGACAGATGTTATAAAATACATGGAAGAACATCCAAATCACAATTTGAACGaaaaaatgtttgatttttCATTTGTTATGAAAAGAAAACGCAAGCAACCAGCTGTTTCTACTCCAGCAAAATCTTCTGAAAAGGAAAAACCTGTACCTGTGGTTGCACCAATAGAACCAGTTGAACAACCTGAACCAAACAATAAAGAAGAGAAAGATGAAGatgaTTCAAATTCCCTTAAAATTCTCTTTGAAGATGATGCTTACAAATGTCCTATAGAAGGATGTGGTAAAACTTTCAGAAGAGAAAATCTAGCTCAAATGCATGTTAAACATTACCATCCCGAATATACCAAGTTTCTGGATTCAACACCAAATGTTGCTGATTTAGCATATGCAAGAACAGTTGGTGAAAATCTAGATAGATCTCCAGGACCTCAGAAACCTGCATTAAAAACAGCACCGAAGTCATCCACTCCAAAAACTCCCAAGAACTCAGCATCCACTCTAGAAGAAATGCCTGAATTGAAACCACAAATAAAACCTAAATTAGCTCCAGCAAAAACCAAAGATCAAGAAATAATAAAACTGTTGAATACCAAACCATTTAACAAAGAGGAGATTAATGTTCAACAGCCACAAATCTCAGAAGATGCTAGTCCACCTTATTCTGACcaaaaattgaaagaagcaTTAACTAAGAGTGATAGTGTCCCTAAAAAGGAAGAAATAACTTTGAAAACTTTATTGAAGAGTAAACCTTCTGGCATAAAAACTCTACTACCTGTTCATCGACCTCAAACAGAGAATTTAGCAGCTGAACAATTAGATGAAGAACACTACAAACCACCGTCAAAGCGCAAGTCAGCGTTTACAGAAAGTATAGAAATAATAAAAGGTACAGAAAAAACTGAAACTAAATTTCCACCTTCACCTACAAAAGTTAAAACTCCACCATTACCATTACCACCAATGCCATCATTATCACAACAAACATCACAATCTTCTTCTCCATTATGTGCTCCTATTCTTCCTCCTCAAATAGAACCACCTCCTCTATCTATCCCTAGTCCTTCCTCTAATAATGTAATAATTGAAGGCGGAGAAGTTATTAAGATCGTCAGAATGAAACAAGAAGAAATTATTAACTGCACTTGCGGATTTATGGAAGAAGATGGTTTGATGATCCAATGTGAATTATGTCTATGTTGGCAACACGCCTATTGCAACAACATCGAGAGAGAAAGTCAAGTTCCCGATAAGTATGTTTGTTATATTTGTCAAAATCCACTTCGAGAAAGATCGAGCAGAAAATATTATCACGATCAAGATTGGTTGACAAAAGGAGTGCTTCCAGTGGGAAGTTACCATACCAAAGACGATGAAGCCTTACACAAGAGGTTTGACAAATTGAAGAAGTGTCACGATTTGTCAGGAGGATTAATAGAACTTGGAAATTATCAACATAGTTTGAAAATAAAGATGAAGATAGCCGAAGTGAAGAATCATCCAAAATTATACTTGTGGTCAAAACCTTGGGCTAAAAAATGCCTACCTGAAAAAGCCAAACCAGAAATAGAAGATAATAAAACGAAAATAGAGAGTGAAGTTCCAGAATTTCTTAAAAACGACTTTGACGTTGACAAAGAATCTCAAAATGAAAGTTCAATGTTGATGATGCTATTGAAAGATGGTAAAAACGTGATGTCTAAACTTGACGACTTGAATACTCTAATGGACAATAGTCCGATAATACCTCGACCAGAAGCCATTATAGATTCAGCCGACTGTCGATTGAACTTACTAGAACATTTGGTCCACGAATATTCTCTTGTAGAAGAAAGATTAGACGATTTTGAAAGACAACTCAATGTGCTAGAAGAAACGGTTAACGTAGAAAAAGATTTGGAGTATCCAAAAACGAGGAGTACGATGCAGATGCTTATGAGGGATTTGGAGACACTAAAAGAATTTAGCAATAGTTCGGTGTTATAA
Protein Sequence
MGRKCNVESCQSDSNRSQDVGVTFHKVPPHLDIRPKWLSLCRIPEDKKLVKVLYVCSRHFLRADFCNFKGKKYMLKQGVLPSVFPWDKSKLDAIKAESKKDKPVHIKEEPQDDGKSNSDDKQEFAIDGIKQEIIENENSNMETDVKPEPQEEPDDKSTQNSKLPSSNSTFLNFTINSRAEALDFNNEWFPAKIVEIDYEENEVLIHFENYSSKYDEWISMDSSRLRPLQNADESAETSVIDDPVADMDPNSIIHNAAEKPNEMETFVVGERCLATWSNSKKFPATVSKVLENNSYEVLFDDGFVKISKGSSMTKTQGKPLQSSPLFDPIKSSKQDRREKKRKHNVATLFRKRRKLDHSEEKPKKVSTTAVTNVPTQLPPEAELPPLQEIPIVPATPVDIENWKPSWYKGKPVGIEATLQTQDGPKVSYIVPDPRIPPGWNKHILRRTKGCDAGKWDTIIVSPENKRFRSKTDVIKYMEEHPNHNLNEKMFDFSFVMKRKRKQPAVSTPAKSSEKEKPVPVVAPIEPVEQPEPNNKEEKDEDDSNSLKILFEDDAYKCPIEGCGKTFRRENLAQMHVKHYHPEYTKFLDSTPNVADLAYARTVGENLDRSPGPQKPALKTAPKSSTPKTPKNSASTLEEMPELKPQIKPKLAPAKTKDQEIIKLLNTKPFNKEEINVQQPQISEDASPPYSDQKLKEALTKSDSVPKKEEITLKTLLKSKPSGIKTLLPVHRPQTENLAAEQLDEEHYKPPSKRKSAFTESIEIIKGTEKTETKFPPSPTKVKTPPLPLPPMPSLSQQTSQSSSPLCAPILPPQIEPPPLSIPSPSSNNVIIEGGEVIKIVRMKQEEIINCTCGFMEEDGLMIQCELCLCWQHAYCNNIERESQVPDKYVCYICQNPLRERSSRKYYHDQDWLTKGVLPVGSYHTKDDEALHKRFDKLKKCHDLSGGLIELGNYQHSLKIKMKIAEVKNHPKLYLWSKPWAKKCLPEKAKPEIEDNKTKIESEVPEFLKNDFDVDKESQNESSMLMMLLKDGKNVMSKLDDLNTLMDNSPIIPRPEAIIDSADCRLNLLEHLVHEYSLVEERLDDFERQLNVLEETVNVEKDLEYPKTRSTMQMLMRDLETLKEFSNSSVL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

90% Identity
iTF_00910746;
80% Identity
iTF_00735690;