Basic Information

Transcription Factor Domain

TF Family: BTB
Domain: zf-C2H2|ZBTB
PFAM: PF00651
TF Group: Zinc-Coordinating Group
Description: The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 1.5e-21 2.5e-19 70.6 0.8 10 106 61 155 54 159 0.93

2 3 0.27 46 5.4 0.1 76 107 159 190 154 193 0.79

3 3 0.6 1e+02 4.3 0.1 76 109 206 241 195 242 0.83

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	1.5e-21	2.5e-19	70.6	0.8	10	106	61	155	54	159	0.93
2	3	0.27	46	5.4	0.1	76	107	159	190	154	193	0.79
3	3	0.6	1e+02	4.3	0.1	76	109	206	241	195	242	0.83

Coding Sequence: atgGAATCTAGGCTCAAAGGATCTATATCATCTgatgagaaatttttattcctaAATTATGATCTATTTCGAAATTCGCCacaaaatttgcatttttatgtaCGAAGACTCAACAATCAAAGCAGTGCTGTGAtagacgatgaaaaaatacacaaagttATATCAACGTTGAGAAATACAGGTTACGATGTAGTGCTGGATGCTAAAGATGGTCGCCTCAGTGCTCACAGAGCTATTTTATCGCAAAATAGTGAAGTTTTCCAAGCTATGTTCTCTGTTGAAATGAAAGAGTCACAAAATGGTATTGTCAACATGTTGCAATTTGAAGCAAGAGTTGTAAAAAGGATGCTAGATTTCCTATACACAAGACAACTTGGAGAACTAGAAGATATGACGGAATCATTATTTAAACTTGCACATTGTTATGAATTGCACGATTTGTGTCGTTGTTGTGAAGAgtactatatttttaatgtcaaaGTCGATAATGACAGCATTGTCGAAATTCTGAAACTCGCTGATGTTTACGAGCTCGAAAATCTCAATGAGTATGCGGTCAATTTTACTAATCATCATGACCAGGAATTGATTACGCTTGAAAGTTACAGAGAGTATCTTATCCAATCTTTAAATCTAGACAATGCAGTAACTACTCTGCTTTTAGCTGATAAATATAGTACGGTAGATGTTAAAATGAAAgtctttgattttattaaagatAACTATCTGCGAATGATGAGAAATGAGCATTTTTTGGAATTGTTTGAGTCTAAAAGTAGCTTAATGAAGGAAATTCACGTTTATTTGATCAAATAG
Protein Sequence: MESRLKGSISSDEKFLFLNYDLFRNSPQNLHFYVRRLNNQSSAVIDDEKIHKVISTLRNTGYDVVLDAKDGRLSAHRAILSQNSEVFQAMFSVEMKESQNGIVNMLQFEARVVKRMLDFLYTRQLGELEDMTESLFKLAHCYELHDLCRCCEEYYIFNVKVDNDSIVEILKLADVYELENLNEYAVNFTNHHDQELITLESYREYLIQSLNLDNAVTTLLLADKYSTVDVKMKVFDFIKDNYLRMMRNEHFLELFESKSSLMKEIHVYLIK

Sequence clustering based on sequence similarity using MMseqs2