Basic Information

Insect: Galeopsomyia nigrocyanea
Gene Symbol: egg
Assembly: GCA_035047105.1
Location: JAWWMK010000001.1:11967200-11971740[-]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 2.3e-13 2.4e-09 37.8 0.1 5 70 617 676 614 682 0.85

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	2.3e-13	2.4e-09	37.8	0.1	5	70	617	676	614	682	0.85

Sequence Information

Coding Sequence: ATGTCGACTGCCAAACCAGCGGAGGTCATCGATTTGGAATCCGACGATGAGGTCCAGACTGTGGTGAAAGACAAGAAAAAGACCTGCAACACCAACTGCATCAATTTCGCATGTAGCTCCGGTCTGGACATGAGACCCGCGCCATCCTTTGCAATTGCATTTTACGGAGTGAATACtaccaagaagaaaaagaaacgtcaTATTTGCAAGATTTGTTTGGATACTGCCTTGGATCATCAAGAGcaACTGGTAAATGCACTATTAGAGCACAAGCCACTACTCCAATGTGATTTCCCAGATCATACGATGGAAGTTGAGATTTCAGACAGTGATGAGTCGGATGATGGATCAAATATCAAAGATGTATACGTGACAGAAGGTGCACTCGAAGACTTTTCTGCAAGAGTAGACAAAACATTAGCagaagtaatgaaaaaatatgacatCAACTATCAAATTGAAGAAGCAGCCACAGCTCTCAAAAGTGAATGGGATGAAATTGATGaaaaaaataatgctctAGATAAAGACATTACAGATACAATGACCAAACTAGATCAATTACGTGCGTCACTGTATACTGAATTTAAACCAAATGTTAAAATGGAAGATGAATTGATAATTGATGATACGATTTCAAGTGCATCCGCTTATCCTTTGGTAGCAACTAAGAAAGTCACTCAAGTTCGTGCACAGATTAAACCACAACCGCATGACAGTCAACCAGAGATCTTACAAGAAGTTGAAAGGGATAATCGTTTGATTCAATCCATGGACTTACCTCCTAGTGGTATATTGATCAAACCTGTACCAGAGATTGATGACTTTGTATTCACCATAAAGCATCCATTGTTCCCATGGGTTAAAGGAAAGGTCCAAtctattatttctaaaaacCCAATGCAGTACAAAGTCAAGTTACTCCAGAAGAAATATGCTGGTCAAGTGAAAACGTTAACTGGCAAACAAATGGCATCCAACATTCCTAGTCCAGTTATCATCCCTGTTGGTACTCGAGTGGTTGCTATCTTCCAAGATCTAAATTCCAGCAACTACTACAGTGGAGTTATCGCTGAGCCTCCCAAgacaatcaataaattcaGATACTTAATCTTCTTCGACGACGGTTATGCCCAGTATGTTAAGCACAAAGACATCTACTTAGTCTGCGACAGCTCTCCGCGCGTTTGGGAAGATATACCCATGGAATCTCGCGATTTCGTCAAAAAGTATCTCGAATCGTATCCAGAGCGACCAATGGTTAAGCTACAACAAGGTCAAGTAGTGAAAACCGAATGGAATGGCAAATGGTGGATCGCGCGAGTACGCGAAGTTGATGCGAGTTTGGTACAGATGCACTTCGACGCTGATAACAGAACGGAATGGATCTATCGTGGATCTGCAAGATTGGGACCATTGTACTTGGAATTGATGAAGGCTAATCTCAGACAACAGGGTTGTCACTCGTCGCTCAATACACCCAGACGTGCTGCTGTCAATAATaaaaatggACCCTACGTCGAGTACACATCGAACGCAACGGATGAGCGCGAAGCACTCATGACCGACAAGAGCAAACAAGTTGCCACGGCCGAGGACGTTCGAATTCAAGCTGCAGTTCCGCAGCAAAGCCGCGCCGTCGCCAGAAAAAGTACTGCGAAGAAACCAAATCTTCCGGAATCACCGGCTGCTACGCCTTACAATGCTAATATGGAGACGAAGTCTTCTCACAGTATTGTTTATTATCAGACACAAAACAAGATACAAACGAAAAAGTTCGTATCACACCGTTGTGGTCCCGATTGCGTCAAAAGTATCTCCTTCACGCCGGACGATCTACGCGGTTATTCACCGTTGTCTATTCCTCTGCTGTGCGGTTGGAATCGGCAATTATGCAAGTTTCCCAAGAACAAGAAGGTCATTCTTTATCAAGCTCCTTGCGGCGTTCGTCTTAGAAATATGGAGGAGTTGCACAAGTATCTGAGATTGACGAAGTGCCCGATGTCGGTGGATTTGTTCGAGTTTGATTTCTGGGTACATTGCTTGGCGGAATTCGTACTCGACAAGTGCTTCGTCAATATCaaggatCTCAGTTACGGCGTTGAAAACGTGCCGATACCCTGCGTAAACGAGATCGATCACGCTTATCCAGACACGATCAAGTACACGACGCAGCGCGAGCCTTCGGAAGACGTACACATGAATCTCGATCCGGATTTCTTGTGCAGCTGCGATTGCGAGGACGATTGCGCCGATAAGAACAAATGTCAGTGCTGGCAGCTCACCATCCAAGGTGCTACACTTGGTGGTCGCGTGCCGAATGCTGCTGTCGGCTATGTGTACAAGAGACTACCGGAGGCCGTTACTACTGGCATCTACGAGTGTAATTCTAGatgcaAATGTTCAATAAAAACATGCCTGAATCGAGTTGTGCAGCACCCACTCAATCTGAAACTACAAGTATTCAAGACTGCACCAAGAGGTTGGGGTATACGTTGCCTCAACGACATTCCACTGGGTTCCTTTATTTGCATTTACGCCGGACGTCTGCTCACGGAGCAAGGAGCGAACGAAGGTGGCAAGAATTACGGAGACGAGTACTTGGCTGAACTCGATTACGTCGAAGTAGTCGAGGGTATCAAAGAAGGCTACGAGAGCGATGTGCTTGATCCGGAATTGGCTCTCGAAGAGAGCGACTCCGAAAAGGagaaaagcgagaaaaaggACGAAGGGCCGGATTTGCTAAAGGCTCCTTCCAATGATTCGGACGATGATTTTAGTATTGACAAAAAGCTGCAGAAGAATCTAAATATCGTCGACGAAGATGAAGATTCGAGGTCGTCTTCTATCAGgAGCAGACTgaggaagagaaagaaggCTGAAGACAATCTGACTTCCGACAAGTCAGAAGACGGTAGTGTATCTAAGGATGGACAAGACAAAGCAGGtagcgacgaagaagaagccgTTCGTGAACCAAGTAAATTCGATCTCGCCGTCGAcacaatgaaaatcgataaagGCCAATTCAAATCCGTCAGAGACTTTTTCGGAGAGGACGAGGCGGTTTATATTATGGATGCCAAGACTACTGGAAATATTGGACGTTATTTAAATCACTCTTGCGATCCAAACGTTTTCGTGCAAAACGTATTTGTTGATACCCACGATGTGCGCTTCCCTTGGGTCGCATTCTTTGCTCTGAGTTACATCCGAGCTGGCCAAGAGCTCACTTGGAATTACAGTTACGATGTGGGAAGTATTCCCGGTAAAGTTATTATCTGCAGATGTGGTGCCAGCAATTGCAGAGGACGTTTGTTGTAA
Protein Sequence: MSTAKPAEVIDLESDDEVQTVVKDKKKTCNTNCINFACSSGLDMRPAPSFAIAFYGVNTTKKKKKRHICKICLDTALDHQEQLVNALLEHKPLLQCDFPDHTMEVEISDSDESDDGSNIKDVYVTEGALEDFSARVDKTLAEVMKKYDINYQIEEAATALKSEWDEIDEKNNALDKDITDTMTKLDQLRASLYTEFKPNVKMEDELIIDDTISSASAYPLVATKKVTQVRAQIKPQPHDSQPEILQEVERDNRLIQSMDLPPSGILIKPVPEIDDFVFTIKHPLFPWVKGKVQSIISKNPMQYKVKLLQKKYAGQVKTLTGKQMASNIPSPVIIPVGTRVVAIFQDLNSSNYYSGVIAEPPKTINKFRYLIFFDDGYAQYVKHKDIYLVCDSSPRVWEDIPMESRDFVKKYLESYPERPMVKLQQGQVVKTEWNGKWWIARVREVDASLVQMHFDADNRTEWIYRGSARLGPLYLELMKANLRQQGCHSSLNTPRRAAVNNKNGPYVEYTSNATDEREALMTDKSKQVATAEDVRIQAAVPQQSRAVARKSTAKKPNLPESPAATPYNANMETKSSHSIVYYQTQNKIQTKKFVSHRCGPDCVKSISFTPDDLRGYSPLSIPLLCGWNRQLCKFPKNKKVILYQAPCGVRLRNMEELHKYLRLTKCPMSVDLFEFDFWVHCLAEFVLDKCFVNIKDLSYGVENVPIPCVNEIDHAYPDTIKYTTQREPSEDVHMNLDPDFLCSCDCEDDCADKNKCQCWQLTIQGATLGGRVPNAAVGYVYKRLPEAVTTGIYECNSRCKCSIKTCLNRVVQHPLNLKLQVFKTAPRGWGIRCLNDIPLGSFICIYAGRLLTEQGANEGGKNYGDEYLAELDYVEVVEGIKEGYESDVLDPELALEESDSEKEKSEKKDEGPDLLKAPSNDSDDDFSIDKKLQKNLNIVDEDEDSRSSSIRSRLRKRKKAEDNLTSDKSEDGSVSKDGQDKAGSDEEEAVREPSKFDLAVDTMKIDKGQFKSVRDFFGEDEAVYIMDAKTTGNIGRYLNHSCDPNVFVQNVFVDTHDVRFPWVAFFALSYIRAGQELTWNYSYDVGSIPGKVIICRCGASNCRGRLL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00968824;
90% Identity: iTF_00326385;
80% Identity: -