Basic Information

Transcription Factor Domain

TF Family: AF-4
Domain: AF-4 domain
PFAM: PF05110
TF Group: Unclassified Structure
Description: This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental disabilities [1]. The family also contains a Drosophila AF4 protein homologue Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila [2].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 1.1e-05 0.44 10.9 0.1 43 76 39 71 33 86 0.73

2 5 1 4.1e+04 -7.5 15.7 456 486 80 113 71 122 0.37

3 5 1 4.1e+04 -23.6 39.3 436 485 98 145 89 157 0.55

4 5 1 4.1e+04 -12.1 30.8 455 482 203 230 190 240 0.67

5 5 3.1e-09 0.00013 22.6 3.3 323 382 237 297 230 318 0.81

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	1.1e-05	0.44	10.9	0.1	43	76	39	71	33	86	0.73
2	5	1	4.1e+04	-7.5	15.7	456	486	80	113	71	122	0.37
3	5	1	4.1e+04	-23.6	39.3	436	485	98	145	89	157	0.55
4	5	1	4.1e+04	-12.1	30.8	455	482	203	230	190	240	0.67
5	5	3.1e-09	0.00013	22.6	3.3	323	382	237	297	230	318	0.81

Coding Sequence: ATGTTCGCTGGAAATCGAGCGGATGATGCAGAGCATGATGCAAGCATCAGTTTTTTTGCCCGTCAGCCCGTAATAATTGCCAATAATTGTGTGTCGAAGGTTATCACGGACGCCCACGACCGCACAACGCAGCAGATCCAGTCGAAGCTGGGCAACTACTCGCTGGTGAAGCACCTGCTTCTGGACGACAACAAGAAGCTGATCGGGATCGAGGGCGTGCCGGCGAGTCCGGCGCCAGCCTCCtccagcggcggcggcgccggCTCCAGGCTCTCTgccccctcctcctcctcctcctcgtcgtccaGCTCCGCCAACCGAAGCTCGCCCTCCTCGCAGGAGTTCAAGAAGCCCGGCGCTAGCGGCCCcaggtcgtcgtcgtcgtcctcctcctccgcCTCCTCCAACGTGCctacctcctcctcctcctcgcaGAGGGGCGGCTTCGTCAAGCCGGCCGATGGCAAGCCGCCCTACGGCGGTCGGGGAGGCTACCCCGGCCAGCCGATCAAgcacggcagcagcagcaacgagcACAGGAGTCACGGCCTTATGACGGCCAAGGGCCCGCCTGcgggtggcggcggcggcggtgcacCCGCCGACGCTGCTCCCTCTTCCATGTCCTCTTCCTCGTcgacctcctcctcctcctcctcctcgacCTCCAGCAGCAATAGCCAATCCAGTCTGCAAAGTAGAATGCACCAGGCGAGCGTGAGAATACCGAAGCTGCCCATCGACACCGCGTCCAACTCCAGGCATCTCAGCGCCGACAGCACCGCCGAAGTGGAGACCATCCTCAAGgAAATGACCATGCCACCGACGCCGCTGACGGCGATCGCACAAACGCCTCGAAAGGAATTCGACTCCAAGTTCACCTTCAACCCCGTCCTCGCCAAGCTCACCGAAGTGCAGCCCCAGGAGTCGACAAAGCCTCGTAAGTATAACCAGCATTAA
Protein Sequence: MFAGNRADDAEHDASISFFARQPVIIANNCVSKVITDAHDRTTQQIQSKLGNYSLVKHLLLDDNKKLIGIEGVPASPAPASSSGGGAGSRLSAPSSSSSSSSSSANRSSPSSQEFKKPGASGPRSSSSSSSSASSNVPTSSSSSQRGGFVKPADGKPPYGGRGGYPGQPIKHGSSSNEHRSHGLMTAKGPPAGGGGGGAPADAAPSSMSSSSSTSSSSSSSTSSSNSQSSLQSRMHQASVRIPKLPIDTASNSRHLSADSTAEVETILKEMTMPPTPLTAIAQTPRKEFDSKFTFNPVLAKLTEVQPQESTKPRKYNQH

Sequence clustering based on sequence similarity using MMseqs2