Basic Information

Insect: Frieseomelitta varia
Gene Symbol: PAX6
Assembly: GCA_011392965.1
Location: WNWW01000707.1:70322-94094[-]

Transcription Factor Domain

TF Family: PAX
Domain: PAX domain
PFAM: PF00292
TF Group: Helix-turn-helix
Description: The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 1.7e-68 2.2e-65 217.4 0.2 1 119 119 237 119 244 0.98

2 2 0.44 5.6e+02 -0.4 0.0 114 125 311 322 304 322 0.87

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	1.7e-68	2.2e-65	217.4	0.2	1	119	119	237	119	244	0.98
2	2	0.44	5.6e+02	-0.4	0.0	114	125	311	322	304	322	0.87

Sequence Information

Coding Sequence: ATGGACGTACCTTTTCCACGCGATGCACCCGGAGAAGCGGCTCTGACAGATCCGTTGGCGCGGAATAACGCGTTTACGAGCTCTTTGTCCGGTCCGCTTTGGACCACGGACCGCCTCGTGCTACCGTTGCTGTTGCCGCTGCCGCCCTGGCTGTCGTCGATCCACATCTATCCGAGCAGGAAAGCTCCAAGgGAACGCGAGCGACTGACAACGTTACggagaaatttggaaaacaaTTCTTCAgtcttgaaaaagaaatatacacgATTGCTTTTTGCAAAACGTTGGGCATCCGCGTCCGTGTCTGGATGGTGGACGATTCGATTTCTTCATCGAcgtatcgttttattttcaggTCACAGTGGCGTGAATCAGCTCGGAGGTGTGTTCGTCGGCGGTAGACCGCTTCCAGACTCGACGAGGCAAAAGATCGTCGAGCTGGCGCATTCGGGTGCGAGGCCTTGCGACATCTCTAGGATCCTACAGGTTAGCAATGGCTGCGTCTCGAAGATTCTTGGGAGgTACTATGAAACCGGATCGATCAGGCCCAGAGCGATCGGTGGCAGTAAGCCACGCGTAGCCACGGCAGAAGTCGTAAGCAAGATCTCCCTCTACAAGAGCGAGTGCCCCTCCATCTTTGCGTGGGAGATCAGAGATCGTTTGCTCCAGGAAGGCGTCTGTACCAACGATAATATCCCTAGCGTGAGTACACAAGTTTCCTTTAAtcgttttaacaatttttccattCCTCCTTCCCCGGTTGGATTTGAATCTGGCACCCGGCGTGGCGGACGCGTTATTGGTTTACTCGCACCACTGATTCCGGAATACTATCAGTGGTTCTCGGCCAATTCTCCAGGATACCTGTACCTCGCTAAAAAATTCTTCCGCCGCTTTAATTTTCCCattgttaaaaagtttcttataGAAGTAGAAAAGgtGTCATCTATAAACAGGGTATTGAGAAATTTAGCGGCACAGAAAGAGCAAcgacagcaacaacagcagcagcagcaaggAGTGGCTACTGTTGGCGTTGGAGTCGGTGCTGGCAGTCCAGCTGAGAGCGTTTACGACAAATTGAGGCTGCTGAACGGGCAAACCACTGGCTGGCCGAGGCCCAATCCatgGTATCCATCTGGAGCTGGCAGTCCATTTCCATCCCTGCAGCCCAGCTTGAGTCCGAGTCATTGTACAGCTCTGCCGCCGGATCCTGCGGATATTCTGCACGCAAAGAAGGGCGCGTTTTGTCGTCAGTGCGTTCCTCTGCTCTGCTTCTACTACTTCGTCTTCTGGAGCCCCCCATGTCCCAGTAGGTAG
Protein Sequence: MDVPFPRDAPGEAALTDPLARNNAFTSSLSGPLWTTDRLVLPLLLPLPPWLSSIHIYPSRKAPRERERLTTLRRNLENNSSVLKKKYTRLLFAKRWASASVSGWWTIRFLHRRIVLFSGHSGVNQLGGVFVGGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATAEVVSKISLYKSECPSIFAWEIRDRLLQEGVCTNDNIPSVSTQVSFNRFNNFSIPPSPVGFESGTRRGGRVIGLLAPLIPEYYQWFSANSPGYLYLAKKFFRRFNFPIVKKFLIEVEKVSSINRVLRNLAAQKEQRQQQQQQQQGVATVGVGVGAGSPAESVYDKLRLLNGQTTGWPRPNPWYPSGAGSPFPSLQPSLSPSHCTALPPDPADILHAKKGAFCRQCVPLLCFYYFVFWSPPCPSR

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: -
90% Identity: -
80% Identity: -