Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 8 2.8 2.3e+03 -1.3 0.0 22 46 23 47 16 52 0.78

2 8 0.00025 0.21 11.6 0.0 20 52 77 109 70 110 0.88

3 8 0.09 74 3.5 0.0 22 46 107 131 104 137 0.86

4 8 0.0036 2.9 7.9 0.0 20 45 133 158 129 161 0.89

5 8 0.008 6.6 6.8 0.0 21 47 162 188 158 194 0.86

6 8 0.019 15 5.6 0.0 21 45 190 214 186 217 0.90

7 8 0.014 12 6.0 0.0 21 45 218 242 214 245 0.90

8 8 6.2 5.1e+03 -2.4 0.1 25 36 287 298 281 302 0.77

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	8	2.8	2.3e+03	-1.3	0.0	22	46	23	47	16	52	0.78
2	8	0.00025	0.21	11.6	0.0	20	52	77	109	70	110	0.88
3	8	0.09	74	3.5	0.0	22	46	107	131	104	137	0.86
4	8	0.0036	2.9	7.9	0.0	20	45	133	158	129	161	0.89
5	8	0.008	6.6	6.8	0.0	21	47	162	188	158	194	0.86
6	8	0.019	15	5.6	0.0	21	45	190	214	186	217	0.90
7	8	0.014	12	6.0	0.0	21	45	218	242	214	245	0.90
8	8	6.2	5.1e+03	-2.4	0.1	25	36	287	298	281	302	0.77

Coding Sequence: ATGCAGGACCAATCTATCGTTTCCCATGAAATGGTCCCCTTTCAAAGCAAGCCAACCCACACCGAAGAAAAGTTTGTAGAATGcaatgtgtgcaacaagaaattttcgacaCATAGTTCCCTTAATCGTCACACACGCCTTCACACGGGAGTGAAAATTTTTGAATGTACTGAGTGTAACATGAAATTTTCGCGAGGAGACCATCTTCGTACTCATCTTAGCACCCACACCGgggagaagccctttgagtgcactgtgtgtaacaagaaattttcgataAGTGGAAATCTGCGCACTCATTTACGCcttcacacgggagagaagccctttgaatgCACTGAGTGTAACATGAAATTTTCGCAAGGAGCCCATCTTCGTACTCATCTTAGCACCCACACCGgggagaagccctttgagtgcactgtgtgtaaGAAGAAATTTTCGATAAGTGGAAATCTGCGCACTCATTTacgcacccacacgggagagaagccctttgaatgCACTGTGTGTAACATGAAATTTTCGGAAAGTGGCGGTCTTCGCCAACATTTacgcacccacacgggagagaagccctttgagtgcactgtgtgtaaCAAGAATTTTTCGGAAAGTGGCAGTCTGCGCACTCATTTACGCACCCACACCGgtgagaagccctttgagtgcactgtgtgtaacaagaaattttcgaaaaGTGGCAGTCTGCGCACTCATTTACGGACCCACACGGGAGATGCACtgtgtgtaacaagaaattttcgaaaaGTGGCAGTCTGCGCACTCATTTAcggacccacacgggagagaagccctttgaatgcactgtgtgtaacaagaaattttcgaaaaGTGGCCATCTGCGCACTCATTTacgcacccacacgggagagaaaccctttgagtgcactgtgtgtaaCATGA
Protein Sequence: MQDQSIVSHEMVPFQSKPTHTEEKFVECNVCNKKFSTHSSLNRHTRLHTGVKIFECTECNMKFSRGDHLRTHLSTHTGEKPFECTVCNKKFSISGNLRTHLRLHTGEKPFECTECNMKFSQGAHLRTHLSTHTGEKPFECTVCKKKFSISGNLRTHLRTHTGEKPFECTVCNMKFSESGGLRQHLRTHTGEKPFECTVCNKNFSESGSLRTHLRTHTGEKPFECTVCNKKFSKSGSLRTHLRTHTGDALCVTRNFRKVAVCALIYGPTRERSPLNALCVTRNFRKVAICALIYAPTRERNPLSALCVT

Sequence clustering based on sequence similarity using MMseqs2