Basic Information

Gene Symbol
-
Assembly
None
Location
ML762997.1:1149160-1152703[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 18 0.14 7.5 7.1 0.1 2 20 21 39 20 41 0.91
2 18 0.76 41 4.8 0.2 5 23 105 123 101 123 0.90
3 18 0.00045 0.025 14.9 1.4 1 23 131 153 131 153 0.98
4 18 0.13 7.2 7.2 0.6 1 23 159 181 159 181 0.96
5 18 0.0046 0.25 11.8 1.7 3 23 189 209 188 209 0.96
6 18 0.016 0.87 10.1 2.3 1 23 215 237 215 237 0.96
7 18 0.0023 0.13 12.7 1.7 1 23 243 265 243 265 0.96
8 18 3.5e-06 0.00019 21.6 0.3 1 23 271 293 271 293 0.96
9 18 0.0016 0.088 13.2 0.1 1 23 299 321 299 321 0.92
10 18 5.6e-06 0.0003 20.9 1.0 1 23 327 349 327 349 0.98
11 18 1.7e-05 0.0009 19.5 0.5 2 23 356 377 355 377 0.96
12 18 0.0045 0.24 11.8 0.3 1 23 402 424 402 424 0.96
13 18 0.00014 0.0078 16.5 0.1 3 23 432 452 430 452 0.96
14 18 0.00011 0.0062 16.8 1.4 2 23 459 480 458 480 0.95
15 18 5.4e-06 0.00029 21.0 0.7 1 23 486 508 486 508 0.95
16 18 1.7e-05 0.0009 19.4 0.1 1 23 514 536 514 536 0.97
17 18 6.1e-05 0.0033 17.7 1.3 1 23 622 644 622 644 0.97
18 18 0.24 13 6.4 0.0 2 23 651 672 650 672 0.96

Sequence Information

Coding Sequence
ATGGAAAAGTCAAATGAAATCGCCATTCTTCAAAGGAAATCGACGAAAGATGGAGGCTCTTCCTGTCCATGGTGTTCAGAAGCGTTTAGTGACCTTCGGGTACTTATGGATCACTGGGAGCACTGCAAGAGCCGACAGCAACTTCAAGACAGTTTAGATTCCTCAAGCGTATCTGATTCAGATACCACTGGTTCTGGTGACATTGGTGAGAAAAATAACAGTGATGATGATAGCATTGCATATCATAGTGAGGGTGAGAAAACTGTAACTGAAGTGTCCAGAAATGGAAATAGTAATTCGCTATCATGTATTCTCTGTAAGCTTGAGTTTAGCAGCGAATTAGATTTGAAAGTTCATGAACAACTTCATCTGAGATGTCATGATAAGAAATACTCTTGCTCTATTTGTGGAGACAATTTCTCTACTAGTATTCTTCTTCATAGTCATCTCAAAAGTCACATAGAATCTAAATCCTTTTCCTGTTCTCAATGTGGAATTCACTCTCTGACAAAAGACGAATATCTGGTACACATGGACATTCATGCTTCTGAAAAATCTAATAATTGTGCAGACTGTCCAGAAAATTTTTCATCTGACAGTGGTTTAAAAAATCACTTTTGCAAACATAACAATGAAAAGAGCTTCTCATGTCATGAGTGCCTCATGAAATTTCATACAGAAGAGGATTTAAAGTTGCACGTGCTTGCACATTCTGATCAAATATTATTCTTCTGTAATCAATGTGATTTAAAGTTTCATTTGCAAAGTGATCTTCAATTACATGTTTTAATTCATCCTAAGCAGAAGATTTTCTCTTGTTTAGAATGTGGTAAAGGTTTCTCTAAAGCAAGTGACTTGAGACGTCACAACCTAGTTCACACTGGAGAGAGACCTTTCCCATGTATAGAATGTGGCTCAAAGTTCGGCACAAGTAGCCAGCTAAAAAGACATGCAATCATACACACAGGATTTCGTCCGTATGCATGCACAGAATGTGAGATGCGGTTCTACAAAGGAAGTGATCTCACTCGCCATATGAGAACTCATACTGGAGAAAAGCTTTTGAAGTGTGACTTCTGTGGGAAAGGTTTCATGCGATTAAATGATCTGAAACGTCATATTTTGCTTCATGACAGAGATAACAACTTTTCTAGTTTTTTCCAAATTGAATCAGCAAGAAACAAGAAGGAGGAAGTATCTCATTTCACATGTGCAGACTGTGGATTTGTTTCCCAAAACTCAGATGAATTTGAAAAACACAAACTTGCACATGGGGATAAAAAATCCCTTGCCTGTTCAGAGTGTAATGCAAGCTTTTCTGAAAATACTGACTGGGAAAAGCACATGATGTCACACTTAGTTGAAAAGCAGCTCTCATGTACATTGtgtgacctcaaattttatacAAGTAGTGATTTAAAGAAACACAGTCTTTCGCATGTACAACATAAACGTTTTCCATGTACTGAGTGTGGAAAAAGCTTTGGAAAGAGAAGTGATTTCAAACGACACTCTGCTGTTCATATGAAAGTAAAGCCATTCACCTGCGGTGATTGTGGTGTGAGTTTTGCTATGGAAAGTCAGCTTAGGAGACACTCAATGATCCATGGAGCTAATAAGTCAACATTTTCAACTGTGAATGATACTTCTCATCAGGCAACAAATGAAATGGTCAGTACAGCAGGATGGCACAATTCAGATATATCTAATATTATTGATATTTATTACAAGGAGTATTTTAAAGAAATAGCATACTTTAACCATTTAAATGAGTCAAGTCAGGCAGGTGTAGATAAAAGCCAGCAGTCATCTGCGGGAAATTCAAATTCCAAACAGCCAAAAGTTGAATCAGGAAACATGGAATACTGTTGCTCTGTGTGTGGAGAAGGCTTCAGCAAAGCATCTAAACTTGTCAAGCATAGCTTAACACATTCCAATGAGACTGGAGTAGTGTGTGCAGTTTGTAAAGCTGAAGTTGGATCAAGAGTTGCACTTGAATCCCACATTCTTACACATATTGAAGAAAAACCCTTTCTTTGTATTGAATGTGGAGATGAATTCCACACTGAATGTGAACTTGAAGCACATTGTTCCAACCATATGAATACCTCATGA
Protein Sequence
MEKSNEIAILQRKSTKDGGSSCPWCSEAFSDLRVLMDHWEHCKSRQQLQDSLDSSSVSDSDTTGSGDIGEKNNSDDDSIAYHSEGEKTVTEVSRNGNSNSLSCILCKLEFSSELDLKVHEQLHLRCHDKKYSCSICGDNFSTSILLHSHLKSHIESKSFSCSQCGIHSLTKDEYLVHMDIHASEKSNNCADCPENFSSDSGLKNHFCKHNNEKSFSCHECLMKFHTEEDLKLHVLAHSDQILFFCNQCDLKFHLQSDLQLHVLIHPKQKIFSCLECGKGFSKASDLRRHNLVHTGERPFPCIECGSKFGTSSQLKRHAIIHTGFRPYACTECEMRFYKGSDLTRHMRTHTGEKLLKCDFCGKGFMRLNDLKRHILLHDRDNNFSSFFQIESARNKKEEVSHFTCADCGFVSQNSDEFEKHKLAHGDKKSLACSECNASFSENTDWEKHMMSHLVEKQLSCTLCDLKFYTSSDLKKHSLSHVQHKRFPCTECGKSFGKRSDFKRHSAVHMKVKPFTCGDCGVSFAMESQLRRHSMIHGANKSTFSTVNDTSHQATNEMVSTAGWHNSDISNIIDIYYKEYFKEIAYFNHLNESSQAGVDKSQQSSAGNSNSKQPKVESGNMEYCCSVCGEGFSKASKLVKHSLTHSNETGVVCAVCKAEVGSRVALESHILTHIEEKPFLCIECGDEFHTECELEAHCSNHMNTS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00732044;
90% Identity
-
80% Identity
-