Basic Information

Transcription Factor Domain

TF Family: zf-LITAF-like
Domain: zf-LITAF-like domain
PFAM: PF10601
TF Group: Zinc-Coordinating Group
Description: Members of this family display a conserved zinc ribbon structure [3] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 1.9 1.8e+04 -1.8 3.0 29 46 4 20 1 26 0.66

2 5 2.9e-05 0.27 13.7 0.1 2 39 29 66 28 72 0.70

3 5 8.3e-05 0.78 12.2 0.0 2 39 71 108 70 115 0.77

4 5 1e-05 0.097 15.1 2.8 2 62 113 178 112 178 0.74

5 5 1.6e-06 0.015 17.7 2.1 2 45 169 215 168 224 0.61

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	1.9	1.8e+04	-1.8	3.0	29	46	4	20	1	26	0.66
2	5	2.9e-05	0.27	13.7	0.1	2	39	29	66	28	72	0.70
3	5	8.3e-05	0.78	12.2	0.0	2	39	71	108	70	115	0.77
4	5	1e-05	0.097	15.1	2.8	2	62	113	178	112	178	0.74
5	5	1.6e-06	0.015	17.7	2.1	2	45	169	215	168	224	0.61

Coding Sequence: ATGCGCCTAATTGTTGCGTTCCTCTACTGCCTACTGCCTACTGCATACTGTCTACTGCCTGCTGCCTACTTCCTACTGCCTACTGCACCGCGAGCTGTCAACTGTCCGCGGTGTTTACAGGACGAGGCGACTGACGTGACCACCGCTGGACAATACAGGAAACAAGCAATGCGCCTAATTGTTGCGTTCCTCTACTGCCTACTGTCTACTGCACCGCGAGCTGTCAACTGTCCGCGGTGTTTACAGGGCGAGGCGACTGACGTGACCACCACTGGACAATACAAGAAACAAGCAATGCGCCTAATTGTTGCGTTCCTCTACTGGCTACTGCCTACTGCACCGCGAGCTGTCAACTGTCCGCGGTGTTTACAGGGCGAGGCGACTGACGTGGCCACCGCTGGACAATACAGGAAACAAGCAATGCGCCTAATTGTTGCGTTTCTCTACTGGCTACTGGCTACTGCCTACTGCCTACTGTCTACTGCCTACTGCCTACTGCCTACTGCACCGCGAGCTGTCAACTGTCCGCGGTGTTTACAGGACGAGGCGACTGACGTGACCACCACTGGACAATACAAGAAACAAGCAATGCGCCTAATTGTTGCGTTCCTCTACTGGCTACTGTCTGCTGTCTGCTGCCTACTGGCTACTGGCTACTGCCTACTGCACCGCGAGCTGTCAACTGTCCGCGGTGTTTACAGGGCGAGGCGACTGACGTGA
Protein Sequence: MRLIVAFLYCLLPTAYCLLPAAYFLLPTAPRAVNCPRCLQDEATDVTTAGQYRKQAMRLIVAFLYCLLSTAPRAVNCPRCLQGEATDVTTTGQYKKQAMRLIVAFLYWLLPTAPRAVNCPRCLQGEATDVATAGQYRKQAMRLIVAFLYWLLATAYCLLSTAYCLLPTAPRAVNCPRCLQDEATDVTTTGQYKKQAMRLIVAFLYWLLSAVCCLLATGYCLLHRELSTVRGVYRARRLT

Sequence clustering based on sequence similarity using MMseqs2