Basic Information

Transcription Factor Domain

TF Family: zf-LITAF-like
Domain: zf-LITAF-like domain
PFAM: PF10601
TF Group: Zinc-Coordinating Group
Description: Members of this family display a conserved zinc ribbon structure [3] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 1.5 1.4e+04 -1.4 1.1 28 44 10 25 2 29 0.43

2 6 1.7e-06 0.016 17.7 3.4 2 62 29 94 28 94 0.72

3 6 0.00052 4.9 9.7 4.1 2 47 85 135 84 154 0.66

4 6 8.8e-05 0.82 12.2 0.5 6 46 155 198 153 204 0.66

5 6 1.3e-05 0.12 14.8 0.5 2 46 207 254 206 260 0.68

6 6 5.9e-06 0.055 15.9 1.9 2 53 263 312 262 315 0.78

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	1.5	1.4e+04	-1.4	1.1	28	44	10	25	2	29	0.43
2	6	1.7e-06	0.016	17.7	3.4	2	62	29	94	28	94	0.72
3	6	0.00052	4.9	9.7	4.1	2	47	85	135	84	154	0.66
4	6	8.8e-05	0.82	12.2	0.5	6	46	155	198	153	204	0.66
5	6	1.3e-05	0.12	14.8	0.5	2	46	207	254	206	260	0.68
6	6	5.9e-06	0.055	15.9	1.9	2	53	263	312	262	315	0.78

Coding Sequence: ATGCGCCTAATTGTTGCGTTCCTCTACTGGCTACTGCCTACTGCCTACTGCCTACTGCCTACTGTCTACTGCCTACTGCCTACTGCACCGCAAGCTGTCAACTGTCCGCGGTGTTTACAGGGCGAGGCGACTGACGTGGCCACCGCTGGACAATACAGGAAACAAGCAATGCGCCTAATTGTTGCGTTCCTCTACTGGCTACTGCCTATTGCCTACTGCCTACTGCCTACTGTCTACTGCCTACTGCCTACTGCACCGCGAGCTGTCAACTGTCCGCGGTGTTTACAGGGCGAGGCGACTGACGTGGCCACCGCTGGACAATACAGGAAACAAGCAATGCGCCTAATTGTTGCGTTCCTCTACTGGCTACTGCCTACTGCCTACTGCCTACTGCCTACTGCCTACTGCCTACTGCCTACTGCCTACTGCCTACTGCCTACTGTCTACTGCCTACTGCCTACTGTCAACTGTCCGCGGTGTTTACAGGGCGAGGCGACTGACGTGGCCACCGCTGGGCAATACAGGAAACAAGCAATGCGCCTAATTGTTGCGTTCCTCTACTGCCTACTGCCTACTGCATACTGTCTACTGCCTGCTGCCTACTTCCTACTGCCTACTGCACCGCAAGCTGTCAACTGTCCGCGGTGTTTACACGGCGAGGCGACTGACGTGGCCACCGCTGGGCAATACAGGAAACAAGCAATGCGCCTAATTGTTGCGTTTCTCTACTGCCTACTGCCTACTGCCTACTGTCTACTGCCTGCTGCCTACTTCCTACTGCCTACTGCACCGCAAGCTGTCAACTGTCCGCGGTGTTTACAGGGCGAGGCGACTGACGTGGCCACCGCTGGGCAATACAGGAAACAAGCAATGCGCCTAATTGTTGCGTTTCTCTACTGCCTACTGCCTACTGTCTACTGCACCGCGAGCTGTCAACTGTCCGCGGTGTTTACAGGGCGAGGCGACTGA
Protein Sequence: MRLIVAFLYWLLPTAYCLLPTVYCLLPTAPQAVNCPRCLQGEATDVATAGQYRKQAMRLIVAFLYWLLPIAYCLLPTVYCLLPTAPRAVNCPRCLQGEATDVATAGQYRKQAMRLIVAFLYWLLPTAYCLLPTAYCLLPTAYCLLPTVYCLLPTVNCPRCLQGEATDVATAGQYRKQAMRLIVAFLYCLLPTAYCLLPAAYFLLPTAPQAVNCPRCLHGEATDVATAGQYRKQAMRLIVAFLYCLLPTAYCLLPAAYFLLPTAPQAVNCPRCLQGEATDVATAGQYRKQAMRLIVAFLYCLLPTVYCTASCQLSAVFTGRGD

Sequence clustering based on sequence similarity using MMseqs2