Basic Information

Transcription Factor Domain

TF Family: zf-LITAF-like
Domain: zf-LITAF-like domain
PFAM: PF10601
TF Group: Zinc-Coordinating Group
Description: Members of this family display a conserved zinc ribbon structure [3] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 4 2.1 1.9e+04 -1.9 0.7 55 66 11 22 2 26 0.73

2 4 10 9.4e+04 -11.5 11.5 40 46 91 97 80 106 0.59

3 4 6.5 6e+04 -3.4 2.0 44 52 123 131 120 143 0.62

4 4 1.6e-14 1.5e-10 43.4 9.9 4 69 166 231 163 232 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	4	2.1	1.9e+04	-1.9	0.7	55	66	11	22	2	26	0.73
2	4	10	9.4e+04	-11.5	11.5	40	46	91	97	80	106	0.59
3	4	6.5	6e+04	-3.4	2.0	44	52	123	131	120	143	0.62
4	4	1.6e-14	1.5e-10	43.4	9.9	4	69	166	231	163	232	0.96

Coding Sequence: ATGTGCAGTGAGAGTTTCCAAGAATGTTTTGTGCAGTACCGATGCTTGGTGTGTGGAGAAATCCTCAGAAGCAGCCGGCCAGATGCGCTTATCCAGCACTTGCGTCGGAGACACCCGTTCATCAACATGGGCCGCCCCCCCTCTCCTGCTGCCGTGAGGCGGCCATGCCCACCGCCCTGCCCAGTGCCGCGGCCGCCCAACCGATGTCCGTGTCCTCCGATGTTGCCGGTGCCGCCCGTCCCACCACCTTGCCCACCATGCACCCGCCCCTGCTGCCCCCCCTGCATCCCCTGCCCGCCCCCACCCTGCACCCCCTGCCCCCCGCAGCCCTGCCCCCCGCCCCCACCGAACCCTCCGCCCCCCTGCCCCGCCCCCTGTGCTGTCAATTGCTGCCCGCCCCAGCAGGCCGACTACTGCCGGGCCATGGAGAAACAGAGACGGAAGGAGTATCGTACCAAGTACAAATGCACAGTTGAGTCATGGAAGCCGGGATGTACGAAGGTGATTTGCCCTTGTTGCGGCTGCGAGGCCCAGCCCATCATCCGACGCCAGCGCAACCAGCTGGCCAGCAGCTCTCTCGGGGCCTGCCTCATGCTCGGTTGTTGGCCGCTATCGTTTCTGCCGTTTATGCTGTGCGAGAGCCAGGTTGTGAACCTGTATTGTGCCCAGTGTAACAACTTCCTGGGTGCCTACAACCAGAAGGAAGGCTGCATCATCGATGTGGAGGCACAGCTGTGTAATCCTGGCGTCGTTCCAAACTTCCCTTCTATCCCGCACTAA
Protein Sequence: MCSESFQECFVQYRCLVCGEILRSSRPDALIQHLRRRHPFINMGRPPSPAAVRRPCPPPCPVPRPPNRCPCPPMLPVPPVPPPCPPCTRPCCPPCIPCPPPPCTPCPPQPCPPPPPNPPPPCPAPCAVNCCPPQQADYCRAMEKQRRKEYRTKYKCTVESWKPGCTKVICPCCGCEAQPIIRRQRNQLASSSLGACLMLGCWPLSFLPFMLCESQVVNLYCAQCNNFLGAYNQKEGCIIDVEAQLCNPGVVPNFPSIPH

Sequence clustering based on sequence similarity using MMseqs2