Basic Information

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 10 0.0097 1.8e+02 4.1 0.1 38 48 73 83 19 98 0.77

2 10 0.036 6.7e+02 2.3 0.0 36 48 95 107 93 109 0.87

3 10 0.037 7e+02 2.2 0.0 36 48 107 119 105 120 0.86

4 10 0.033 6.2e+02 2.4 0.0 36 48 119 131 117 134 0.87

5 10 0.037 7e+02 2.2 0.0 36 48 131 143 129 144 0.86

6 10 0.037 7e+02 2.2 0.0 36 48 143 155 141 156 0.86

7 10 0.021 3.8e+02 3.1 0.1 37 48 156 167 153 182 0.68

8 10 0.037 7e+02 2.2 0.0 36 48 179 191 177 192 0.86

9 10 0.043 8e+02 2.0 0.0 36 47 191 202 188 203 0.86

10 10 0.017 3.1e+02 3.4 0.0 37 48 204 215 201 230 0.60

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	10	0.0097	1.8e+02	4.1	0.1	38	48	73	83	19	98	0.77
2	10	0.036	6.7e+02	2.3	0.0	36	48	95	107	93	109	0.87
3	10	0.037	7e+02	2.2	0.0	36	48	107	119	105	120	0.86
4	10	0.033	6.2e+02	2.4	0.0	36	48	119	131	117	134	0.87
5	10	0.037	7e+02	2.2	0.0	36	48	131	143	129	144	0.86
6	10	0.037	7e+02	2.2	0.0	36	48	143	155	141	156	0.86
7	10	0.021	3.8e+02	3.1	0.1	37	48	156	167	153	182	0.68
8	10	0.037	7e+02	2.2	0.0	36	48	179	191	177	192	0.86
9	10	0.043	8e+02	2.0	0.0	36	47	191	202	188	203	0.86
10	10	0.017	3.1e+02	3.4	0.0	37	48	204	215	201	230	0.60

Coding Sequence: ATGTCCCAAATCTACATATTAATCGCACGATATTTAGATTTCTCAGAAAATTTAAGAGAAATCTTATTCCCAAATTCCGGATGGAGATTTCAAGTAATACAAGATATTGCAAAGAAAACGGTGGTCAGGATCGGCGTGATCTGCTACCTGGAGGCGACCACAGAAGATTTCACCCAATCCCCGTGCGTTGCCCGGCTCCGAGATTTCACCCAATCCCCGTGCGGTGACCGGCTCAGAGATTTCACCCAATCCCCGTGCGGTGACCGGCTCAGAGACTTCACCCAATCTCCGTGCGGTGACCGGCTCAGAGACTTCACCCAATCTCCGTGCGGTGACCGGCTCAGAGATTTCACCCAATCCCCGTGCGGTGACCGGCTCAGAGACTTCACCCAATCTCCGTGCGGTGACCGGCTCCGAGATTTCACCCAATCCCCGTGCGGTGACCGGCTCAGAGATTTCACCCAATCTCCGTGCGGTGACCGGCTCAGAGACTTCACCCAATCCCCGTGCGGTGACCAGCTCAGAGATTTCACCCAATCTCCGTGCGGTGACCGGCTCAGAGATTTCACCCAATCCCCGTGCGGTGACCGGCTCAGAGACTTCACCCAATCTCCGTGCGGTGACCGGCTCAGAGACTTCACCCAATCTCCGTGCGGTGACCGGCTCCGAGATTTCACCCATCCAATTCAAACCGACGAGCTTGCTTGA
Protein Sequence: MSQIYILIARYLDFSENLREILFPNSGWRFQVIQDIAKKTVVRIGVICYLEATTEDFTQSPCVARLRDFTQSPCGDRLRDFTQSPCGDRLRDFTQSPCGDRLRDFTQSPCGDRLRDFTQSPCGDRLRDFTQSPCGDRLRDFTQSPCGDRLRDFTQSPCGDRLRDFTQSPCGDQLRDFTQSPCGDRLRDFTQSPCGDRLRDFTQSPCGDRLRDFTQSPCGDRLRDFTHPIQTDELA

Sequence clustering based on sequence similarity using MMseqs2