Fatl010760.1
Basic Information
- Insect
- Flexamia atlantica
- Gene Symbol
- pax5
- Assembly
- GCA_035578135.1
- Location
- JAQJVK010000001.1:147849581-147852656[-]
Transcription Factor Domain
- TF Family
- PAX
- Domain
- PAX domain
- PFAM
- PF00292
- TF Group
- Helix-turn-helix
- Description
- The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 12 0.00021 2.2 10.6 0.2 1 17 112 128 112 132 0.92 2 12 5.3e-05 0.56 12.5 0.1 2 17 137 152 136 156 0.91 3 12 0.00038 3.9 9.7 0.1 2 17 161 176 160 180 0.91 4 12 0.00036 3.8 9.8 0.1 2 17 185 200 184 204 0.91 5 12 5.3e-05 0.56 12.5 0.1 2 17 209 224 208 228 0.91 6 12 0.00036 3.8 9.8 0.1 2 17 233 248 232 252 0.91 7 12 5.3e-05 0.56 12.5 0.1 2 17 257 272 256 276 0.91 8 12 0.00036 3.8 9.8 0.1 2 17 281 296 280 300 0.91 9 12 5.3e-05 0.56 12.5 0.1 2 17 305 320 304 324 0.91 10 12 0.00036 3.8 9.8 0.1 2 17 329 344 328 348 0.91 11 12 0.00036 3.8 9.8 0.1 2 17 353 368 352 372 0.91 12 12 5.9e-34 6.2e-30 106.0 0.3 2 60 377 435 376 445 0.94
Sequence Information
- Coding Sequence
- ATGACACGGCCGCCATATGCCGAGGTGTCAATTGACTATTCAGCAGACTGTCGGTTAATTATTCGGCCGGCCGATGACATCGGACACGACTGTTTCATAGACTCAACCTTAATTGCCACTTCTCCCGGGTTTCTGCGATTCCCTCGCTCGCTCGCGGTTATCGAGTCGCTAATGAATGCACTATCGTCGTCCTGTGTGGTGGCAAGTGCAGTGGAGCAGTGTCAGCGGTTGCGGCGAGGCTGCGGCCAAGAGCCGGCTAAACGTGCGCGGTCCGGTTACAGCCGCAACACAGAGGAAGCTACGACCACGTCCGTGCATCACAGTTCCCCGTCTGGTCACGGCGGCGTCAACCAGCTGGGCGGGGCGTTCGTCCACGGCCGTGCATCACAGTTCCCTGTCTGGTGTTGTCACGGCGGCGTCAACCAGCTGGGCGGGGTGTTCGTCCACGGCCGTGCATCACAGTTCCCTGTCTGGTGTTGTCACGGCGGCGTCAACCAGCTGGGCGGGGCGTTCGTCCACGGCCGTACATCACAGTTCCCTGTCTGGTGTTGTCACGGCGGCGTCAACCAGCTGGGCGGGGCGTTCGTCCACGGCCGTGCATCACAGTTCCCTGTCTGGTGTTGTCACGGCGGCGTCAACCAGCTGGGCGGGGTGTTCGTCCACGGCCGTGCATCACAGTTCCCTGTCTGGTGTTGTCACGGCGGCGTCAACCAGCTGGGCGGGGCGTTCGTCCACGGCCGTGCATCACAGTTCCCTGTCTGGTGTTGTCACGGCGGCGTCAACCAGCTGGGCGGGGTGTTCGTCCACGGCCGTGCATCACAGTTCCCTGTCTGGTGTTGTCACGGCGGCGTCAACCAGCTGGGCGGGGCGTTCGTCCACGGCCGTGCATCACAGTTCCCTGTCTGGTGTTGTCACGGCGGCGTCAACCAGCTGGGCGGGGTGTTCGTCCACGGCCGTGCATCACAGTTCCCTGTCTGGTGTTGTCACGGCGGCGTCAACCAGCTGGGCGGGGCGTTCGTCCACGGCCGTGCATCACAGTTCCCTGTCTGGTGTTGTCACGGCGGCGTCAACCAGCTGGGCGGGGCGTTCGTCCACGGCCGTGCATCACAGTTCCCTGTCTGGTTTTGTCACGGCGGCGTCAACCAGCTGGGCGGGGTGTTCGTCAACGGCCGGCCGCTGCCAGACGTCGTGCGGCAGAGGATAGTCGAACTGGCGCACAACGGCGTCAGACCCTGTGATATCTCGAGGCAACTCAGAGTTTCCCATGGCTGTGTTTCTAAAATTCTATCTAGTTTTTACAACttggatctttttaaaaataaaaactgcgaCGCGGTTCCTTCAGCAGACTGCGACGGTGCAGGCTGCAGCGCGGAGAGTAGTGTAGCTAGCCGCGGATTGAGGGCAGGCTACCGCCGTATCGCCCATCTGGGCCCCGAGGCTGTTTGA
- Protein Sequence
- MTRPPYAEVSIDYSADCRLIIRPADDIGHDCFIDSTLIATSPGFLRFPRSLAVIESLMNALSSSCVVASAVEQCQRLRRGCGQEPAKRARSGYSRNTEEATTTSVHHSSPSGHGGVNQLGGAFVHGRASQFPVWCCHGGVNQLGGVFVHGRASQFPVWCCHGGVNQLGGAFVHGRTSQFPVWCCHGGVNQLGGAFVHGRASQFPVWCCHGGVNQLGGVFVHGRASQFPVWCCHGGVNQLGGAFVHGRASQFPVWCCHGGVNQLGGVFVHGRASQFPVWCCHGGVNQLGGAFVHGRASQFPVWCCHGGVNQLGGVFVHGRASQFPVWCCHGGVNQLGGAFVHGRASQFPVWCCHGGVNQLGGAFVHGRASQFPVWFCHGGVNQLGGVFVNGRPLPDVVRQRIVELAHNGVRPCDISRQLRVSHGCVSKILSSFYNLDLFKNKNCDAVPSADCDGAGCSAESSVASRGLRAGYRRIAHLGPEAV
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- -
- 90% Identity
- -
- 80% Identity
- -