Basic Information

Gene Symbol
-
Assembly
GCA_900060175.1
Location
FIZR01012446.1:23168-26003[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 22 0.0078 0.71 10.6 7.2 2 23 200 221 199 221 0.96
2 22 5.4e-07 4.9e-05 23.7 1.3 1 23 227 249 227 249 0.99
3 22 4.4e-08 4e-06 27.1 3.1 1 23 255 277 255 277 0.98
4 22 7.9e-05 0.0072 16.9 1.6 1 23 283 305 283 305 0.98
5 22 0.00035 0.032 14.8 0.1 2 23 312 333 311 333 0.97
6 22 0.0079 0.72 10.6 0.1 1 23 339 361 339 361 0.94
7 22 0.095 8.6 7.2 0.3 1 23 365 388 365 388 0.92
8 22 0.00097 0.088 13.5 0.8 1 23 394 416 394 416 0.97
9 22 2.3e-06 0.00021 21.7 1.7 1 23 422 444 422 444 0.98
10 22 2.5e-08 2.3e-06 27.9 2.0 1 23 450 472 450 472 0.98
11 22 5e-07 4.5e-05 23.8 2.2 1 23 478 500 478 500 0.99
12 22 0.00096 0.087 13.5 3.2 1 23 506 529 506 529 0.97
13 22 0.00014 0.013 16.1 0.3 1 23 536 558 536 558 0.98
14 22 0.0002 0.018 15.6 2.1 1 23 564 587 564 588 0.96
15 22 0.0016 0.15 12.8 0.1 2 23 595 616 594 616 0.96
16 22 5.1e-07 4.6e-05 23.8 0.8 1 23 622 644 622 644 0.98
17 22 1.6e-06 0.00015 22.2 3.9 1 23 650 672 650 672 0.98
18 22 3.1e-05 0.0028 18.2 3.1 1 23 678 700 678 700 0.97
19 22 5.5e-07 5e-05 23.7 4.2 1 23 706 728 706 728 0.99
20 22 3.5e-06 0.00032 21.1 3.9 1 23 734 756 734 756 0.98
21 22 2.8e-05 0.0025 18.3 5.8 1 23 762 784 762 784 0.99
22 22 0.019 1.7 9.4 1.4 2 23 797 819 796 819 0.96

Sequence Information

Coding Sequence
ATGGAATGCACCGAATCTGTATTCATCGAAGAAGGTGCTTGTGAAACAGTCATCGCAGATGATGTAGTAGCCGAGGAAGTAGTACAGAATGAAGATTGCCctcaagaagaagaagaagaagaaaatctGCAAACCACCAATGAAGAAAACGATCAGTGGTATATCTATCTGCTTCAAGCTGATCAAGCCTTACATCAGTTACATGGTACGAAAGTCGAAATTGAATTACCCGAAGAAAAAGTCGAAGTTATCGATGGCGCGTATGAGTGTGAAATAGAAGGTATGGCTCAACTTCAAGGAGAAGCTGTTGCTGTAGAAAACGAAGCACATTACGACTACAATATTGACGCTATTCGTCAAATACAGGAAGCTAAAGTTGAGATTCAGCAGGATGGCTTTAATTACACCATCGATGAGGTGAACCAATTTAAACACGAGCCTCCAGAAAATCTGGACAATTTGGATCCTAATATTTATAACGAATACGCTTCTGAGgTAATAATTGGAGACGAAGTTGTGATAGGAAACGAGGTAGTAATTGAAACCGATAACACCCTTAATTTGAATTACGCCGAAGAACATTCAGAAATGCCGTTAAGTTGTCGACATTGTAATAAAACATTCCACAAACGTAATAAGCTAGAACAACACGAACGTATGCACACCGGCGAGCGACGATTTAAATGCCCTCATTGTGAAAAAGGATTCAACCAACGAGTAAATTTAGATAATCACATACGAGTTCACACTGGcgaaaaaccattttcatgtgattattgtaaaaaaagctTCAGTCAGCaaggaaatttgaaaactcaCATGCAGAAACATTTATACATCGAGTATTTCATTTGTCCACATTGTAAAGATAACTTTCGTTCGAAAGTTGAACTAAACGAGCATATAAAAACTCACAGGGATAATATCATACTCGAATGTCCGTTCTGTCAGATGGTTTTCAATACCGAAGATGAAGTAAATGAGCATTTACAAACACATTCCGGCGATCAATTGTTTTTATGCTTAATCTGTAAAGAAAACTTCGGTTCTCAAGAAGAGCTCAACGGTCATGTTAAACTTCACAGCCAAAATTACGAATGTATTTATTGCAAACAAATGTTCGAACAAGAAGAAGATCTTCTCGAGCATTTCGATAGATTACATCGTAATGGAAACGTGTTCGAGTGTACTTATTGTAAACAGTATTTCGAAACAGCTGCCGAACTAAATTACCATAGCGATACCCATAAAGGTGAGAATCCATTCAAATGTCAGTACTGCGGTGAACGATTTTATACCGAATCTTTGCTAACGAAACATGTTAAACTTCACGAAGGCACCAAGTCATTCGTTTGCTCGTATTGTAATCGTAGCTTTAGCCAGAAAGGTAATTTGAACACACACATCAGACGACACACCGGTGAAAGACCGTTCAAATGCAACGGTTGTAATAAAATGTTCAGCGATTATTCAACGTATACCAGACACGTTCGAGTACACACTAAAGAAAAACCCTACTCTTGCGAATACTGCTTACGACCATTTTCGCAGTTATCCAACTTAAAATGTCATATTCAAAGACGTCACGATCGAGTAGAAAGCAAATACGAATGCGAATTTTGTGTAAAACAATTCGAAAACAAGGAAGAACTGTTAGAACATTTGGAAACGCATACCGGTGATAAACCATACGTTTGTCAAGTCTGCCTGAAAAGCTTCAGCCAATGGgcaaatttaaaatgtcacattttaaGCGGTCATCACGCCAAACAAGGTTTACTAATTTGCGAATATTGCGAAGCGTACTACGACTCGCAAGAGAGTCTCGAAGAGCATTTGAAAACCCACACCGGTAAAAATCCCTATATCTGTAACGTTTGCCAAAAAACCTACAGTTCTTCGGCCAATTTGAAGAAACACGTTAAAATACACACCAGCGTGAAAAACTTTCCATGCGACGTATGCCATAAAGCATTCTACACTCATTCTCTTCTCAAGAATCATATGATGACGCATCAAGGAGAAAAACCATTCAGTTGCCAATACTGCGATAAAAGTTTCATCAACAAGTATCGCCTGAAAAGCCACACTTATATTCATACCGGCGAAAAACCGTATCAGTGCGATTATTGTCATCGATTTTTCCGAAATCAGTCCGTATTACGACGTCATATTCGTGTACATACCGGCGAACATCCGTACTCGTGTCCTTATTGcaagaaaactttcaaaacacATTCTGAAAATAAACTTCACATCAGAATCCATACCGGCGAAAAACCTTACACTTGCGCTCACTGCAACAAAACCTTCCGTACGCATTCGGCTattaaaatacatcaaaaaactCACGCCACTGATCACAAAATGTTGAGTTTAGGctttcaaaaatgcagttgGTGTTATTCCAAGTTTCGTAACATGGAAGATTTACGCAtgcatgttaaaaaattacacgacgAAAACTGGGAGCCTGAAAATATCCTCGTAAATGCGGCCGGCGAAGAGGTTATGGAAGTAACTTTACCTCAGAATGAAGACGaattcgacgacgacgaagaagaTGAAGtagaagacgaagacgaagttGAAGAAGAATTCGAACTGATCGGACTGGACGATGTTATCAAAACCGAACCCCTCGATAATGATATGATCgaagaaatttcattcttcGTTTGA
Protein Sequence
MECTESVFIEEGACETVIADDVVAEEVVQNEDCPQEEEEEENLQTTNEENDQWYIYLLQADQALHQLHGTKVEIELPEEKVEVIDGAYECEIEGMAQLQGEAVAVENEAHYDYNIDAIRQIQEAKVEIQQDGFNYTIDEVNQFKHEPPENLDNLDPNIYNEYASEVIIGDEVVIGNEVVIETDNTLNLNYAEEHSEMPLSCRHCNKTFHKRNKLEQHERMHTGERRFKCPHCEKGFNQRVNLDNHIRVHTGEKPFSCDYCKKSFSQQGNLKTHMQKHLYIEYFICPHCKDNFRSKVELNEHIKTHRDNIILECPFCQMVFNTEDEVNEHLQTHSGDQLFLCLICKENFGSQEELNGHVKLHSQNYECIYCKQMFEQEEDLLEHFDRLHRNGNVFECTYCKQYFETAAELNYHSDTHKGENPFKCQYCGERFYTESLLTKHVKLHEGTKSFVCSYCNRSFSQKGNLNTHIRRHTGERPFKCNGCNKMFSDYSTYTRHVRVHTKEKPYSCEYCLRPFSQLSNLKCHIQRRHDRVESKYECEFCVKQFENKEELLEHLETHTGDKPYVCQVCLKSFSQWANLKCHILSGHHAKQGLLICEYCEAYYDSQESLEEHLKTHTGKNPYICNVCQKTYSSSANLKKHVKIHTSVKNFPCDVCHKAFYTHSLLKNHMMTHQGEKPFSCQYCDKSFINKYRLKSHTYIHTGEKPYQCDYCHRFFRNQSVLRRHIRVHTGEHPYSCPYCKKTFKTHSENKLHIRIHTGEKPYTCAHCNKTFRTHSAIKIHQKTHATDHKMLSLGFQKCSWCYSKFRNMEDLRMHVKKLHDENWEPENILVNAAGEEVMEVTLPQNEDEFDDDEEDEVEDEDEVEEEFELIGLDDVIKTEPLDNDMIEEISFFV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00194594;
90% Identity
-
80% Identity
-