Fcup000122.1
Basic Information
- Insect
- Ferdinandea cuprea
- Gene Symbol
- slp2
- Assembly
- GCA_963576555.1
- Location
- OY754958.1:2094318-2095625[+]
Transcription Factor Domain
- TF Family
- Fork_head
- Domain
- Fork_head domain
- PFAM
- PF00250
- TF Group
- Helix-turn-helix
- Description
- The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 7.7e-43 1.1e-39 135.3 0.1 1 87 145 230 145 231 0.97
Sequence Information
- Coding Sequence
- ATGGTGAAAATTGACGGTATACAAACATCACCGATTCATCACCAATCTCACGCATTTCTgcaacaccatcatcatcatcatcaccagcaAACGGAGCTTCCGCATACTCCGctattcaacatggcccgaacGCCACACCTGAAGTCCAGTTTCTCGATCAATTCGATTCTCCCCGAGACAGTTGAGAGCAACCGCGATATGGAGCGGCACACACCCACCCCGGAACATTGTCCTGCGTCTCCCCTTGGCTCCGAGGAACAAGATGTCTCCGACATCGAATCCGACCTAGATGTGACAAGTATGTCACCTCCACCGCCGGTGGATGGGAGTGAAGGTAGCGTGAGCAGTCAGCAAAACGAAAACGGCGACAACGATAAAGATGGCGACGATAAACCAAGCGACGGAAACTCCTCCAGTGATAAGAAGGGCAACGAGAAACCACCGTACAGCTACAACGCCTTAATTATGATGGCAATAAGACAGAGTCAGGAAAAAAGGCTCACGCTGAACGGTATTTATGAGTACATCATGACAAACTTTCCGTACTACCGCGACAACAAGCAAGGTTGGCAGAACTCGATACGACATAACCTGAGTCTGAACAAGTGCTTCGTGAAGGTGCCACGACATTATGACGATCCTGGTAAGGGCAATTATTGGATGCTCGATCCGTCGGCCGAGGATGTATTCATCGGCGGTTCAACGGGAAAACTGCGCCGGCGCACTACTGCAGCGTCCAGGTCACGGCTGGCTGCTTTCAAGCGCTCACTTATCGGTCCAATGTTTCCAGGACTGGGATACCCGCAATTTGGACAGTTTTTATATCCTGCCGCagccgcagcagcagcatcagcgCCATCGCTTCTAGCCAGCATGTACAGTCGTTATAACCCATTTGTACCAAAGAATCCAGCGCTTTCACTGCCCATGTCATTCGGTGGAGCGGGGGCGCCATCAGGAATGGGCTCCAATCCAGGATTTCCCGCCAACATGGAACGCCTTCTGTCTTCACCCTCCCACCAAAGCGGTGCCCAAGCACCTTCACTTCCGTCCTCTGCTGAGCTTTACCAACGCCTACAATATCAGCAACTCTTACAACAACATGCCGCAGCGGCAGCTGTAGCCGCCCACCAgcgtcaacaacaacaacaacaacaacagcagcagcatcagcatcaAAACGCTCACCTCCAGCCCCTTCAACTTTCAACACACCTCAGCCAGACAAGTCCTTCAGCGCCCGTGTCACCGACGGTACCGCCAGGACCTATATACAAGCCAGTCACTGTCGTGTCCCGCAACAGTTGA
- Protein Sequence
- MVKIDGIQTSPIHHQSHAFLQHHHHHHHQQTELPHTPLFNMARTPHLKSSFSINSILPETVESNRDMERHTPTPEHCPASPLGSEEQDVSDIESDLDVTSMSPPPPVDGSEGSVSSQQNENGDNDKDGDDKPSDGNSSSDKKGNEKPPYSYNALIMMAIRQSQEKRLTLNGIYEYIMTNFPYYRDNKQGWQNSIRHNLSLNKCFVKVPRHYDDPGKGNYWMLDPSAEDVFIGGSTGKLRRRTTAASRSRLAAFKRSLIGPMFPGLGYPQFGQFLYPAAAAAAASAPSLLASMYSRYNPFVPKNPALSLPMSFGGAGAPSGMGSNPGFPANMERLLSSPSHQSGAQAPSLPSSAELYQRLQYQQLLQQHAAAAAVAAHQRQQQQQQQQQQHQHQNAHLQPLQLSTHLSQTSPSAPVSPTVPPGPIYKPVTVVSRNS
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01044538;
- 90% Identity
- iTF_00310021; iTF_00312390; iTF_00313249; iTF_00389420; iTF_01541231; iTF_01541961; iTF_01223189; iTF_01522367; iTF_01253344; iTF_00314949; iTF_00991562; iTF_00688406; iTF_01299818; iTF_01300630; iTF_01521680; iTF_01520771; iTF_00240466; iTF_01116249; iTF_00976258; iTF_00187853; iTF_01211703; iTF_01044538; iTF_00670747; iTF_00671407; iTF_00672660; iTF_00672011; iTF_00310813; iTF_00984030; iTF_00426152; iTF_00693585; iTF_00694396; iTF_01396290; iTF_00334771; iTF_00426920; iTF_00974442; iTF_00663857; iTF_00664658; iTF_00893663; iTF_00311605; iTF_01356664; iTF_00315741; iTF_00314069;
- 80% Identity
- -