Basic Information

Gene Symbol
topi
Assembly
GCA_029955175.1
Location
JANEYG010000001.1:12976-15956[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 14 0.0037 0.25 12.6 2.1 2 21 106 125 105 126 0.94
2 14 7.5e-06 0.00051 21.1 0.5 1 23 151 173 151 173 0.97
3 14 0.016 1.1 10.6 2.0 3 23 181 201 180 201 0.95
4 14 0.14 9.3 7.6 0.3 2 17 220 235 219 239 0.79
5 14 0.00072 0.049 14.8 1.1 2 23 301 322 300 322 0.97
6 14 2.3 1.6e+02 3.8 0.1 1 12 328 339 328 342 0.88
7 14 0.0043 0.3 12.4 3.2 2 22 365 385 365 388 0.88
8 14 0.03 2.1 9.7 0.1 1 23 517 540 517 540 0.97
9 14 0.0073 0.5 11.6 0.2 1 23 544 566 544 566 0.97
10 14 1.2e-06 8.2e-05 23.6 2.4 1 23 572 594 572 594 0.98
11 14 0.034 2.3 9.5 0.2 1 23 600 625 600 625 0.96
12 14 0.21 14 7.1 2.9 1 23 631 653 631 653 0.85
13 14 4.2e-05 0.0029 18.7 0.3 3 23 661 681 659 681 0.97
14 14 5.7e-06 0.00039 21.4 0.8 1 23 687 710 687 710 0.98

Sequence Information

Coding Sequence
ATGAGCAATCTTgataacataataataaatatgcatAAGATCGCAGAAGATGGAAAAGAGGTTGCCTCTATAAGGCATGAAATGGACCCGAATACGAAGGAGCTGATTTCTAAAACGTATTATACATCGGAAAAAGTAAGTTTTAATTGTATCGATAGCGACAAATTGCACTTAAGCTATAAAAGGTTTGAAATTGAGGAAGAAGTTATAATGTGCTTAAAACTGGAAGATACCCATCAGATATCTAATCTTGCAGAAGCCTCGGACATACCAGCAACAGATAAAAAACCAATCCTcaatattcctacaatgataAGATGCCAAAACTGCGAAACAAATTTTCCAACGAAATATCAGTATCAGCGCCATCAGTGCGAATTTAACGCCGAAAGAGTTGTTCTGAAAGCAGATGCAGACATTAAAGATGTCGATAAAGGCGTTCGTGTTAAATATATCTGTTCAGTTTGTGATAAACAGTTTGTgagcaaaaataatttagatcGTCACCAAGCTAGTCATGAGAACACTCAAGATAACATTTGTGAACACTGTAATAAGCAGTTTGTTAGCGAGAACAGGCTTCGGATCCACAAGGAGAATCACTGTAAGAAATCTGGAGATATATCTAAATTCTATAGGAGCGATGTAACTGTTTGGAAGTGTAAGAAATGCCACGAAGTATTTTCCTCGACTATTACTGCAAATTACCACGTAGCTCTCTGCACAGATATAGTAGAATTTGATGCAGAGACTgaggaaaacaaagaaataaacCGTGTGCATCAGGAAGAGATAAAGAATATTGCTTCATTAATCGCAGACAGCGATTCAAGTAAAGAGAGCTCTTCAGCTTCAGTAGACGATAagaatattgaaaaaatactAACCGAGATACTGCTTCAATGCGAGTTCTGTAACAGAACATACGCTGAAAAAAACTTACTTCTAATGCACCAGAGAAAGCATACCACTACAAAGAATTACGAGTGCGTGAACTGTAATCAAGTGTTTGATTCATATGCTATTGCCGCCCAGCACTGGATGAAGAAATGTTCAGAATATGTTagtcttttttatttaccgAAATTGGCATATTGTGAATACTGTGATAGAACATTTAAATCACACGAATTACTTTATACccataaaataaagaagaagCATTATACTCCTAAGTTGCATGTTCCAAATTCTCCTGATCAAGAAAAGACTGACAACGATGGAAAAGATAAGGCTCTAGATAATAAGCAGATCCTTAACAAGTTGATAGAagatgttttaaaaactttggATGTCCCTGTAAATAGAATAATGAATAATACAAATccaacaaatagtaataataaagaaaatattaatccGGAAAAAGTAAGCGGTATCAGTAAAGTCAAAACCGGAGTCGAAATGGAGAGAGCGGACTCCGGCGTCAATCAAAGTGGTACATCGGAGGTACCAGAGAAGAAGAGAAGGGGTAGGAAACGTAAATGGCCTAAGAATCAGTcgttaaaattgaaaaagttttGCTCCGAAGTAGATGACGGGTTCAAATATCAATGTGAACGTTGCATCAAAGTTTTCGGAACTATTGTGGACCTCGAGGCGCATCGGGAAAAAGAGCATGCAGCAAGTTTCACCTGCGAGGAATGCGGACAAgTCCTCCATAGCGCCAAAGCTCTACTTATTCATAGTCGTGCTCACAAGAGTTTAAAACCATACGTGTGCGAGACATGTGGCAGAAGTTATTCCCAAACCTCCCATTTGTGGCAGCACATGCGGTTCCATCAAGGTATCAAACCTTTTGCTTGCCCACATGAAGGCTGCGAGGCAAGATATACAATAAGACCAGATCTGAAGGATCACATCCGCAAAGTTCATACTCGAGAAAGGCCTTTCAGGTGTACGGTATGCGATAAATGTTTCCTTACTGGGTCCGTTTACTATCAGCACCGTTTGATACATACCAACGATAGGAGGTATGGATGCGATcTTTGCCCTAAAAGATTCTTCAGAGCTGACGCTTTAAACAATCACCGAAGAATCCATACTGACGAAAGGCCGTACCCGTGTCAAGTATGTGGAAGAGAATTTAGGCAGAAGGGCGACAGGAATAAGCATCTTCGTACCCAACATCCTGATGCAATTATAATTTAG
Protein Sequence
MSNLDNIIINMHKIAEDGKEVASIRHEMDPNTKELISKTYYTSEKVSFNCIDSDKLHLSYKRFEIEEEVIMCLKLEDTHQISNLAEASDIPATDKKPILNIPTMIRCQNCETNFPTKYQYQRHQCEFNAERVVLKADADIKDVDKGVRVKYICSVCDKQFVSKNNLDRHQASHENTQDNICEHCNKQFVSENRLRIHKENHCKKSGDISKFYRSDVTVWKCKKCHEVFSSTITANYHVALCTDIVEFDAETEENKEINRVHQEEIKNIASLIADSDSSKESSSASVDDKNIEKILTEILLQCEFCNRTYAEKNLLLMHQRKHTTTKNYECVNCNQVFDSYAIAAQHWMKKCSEYVSLFYLPKLAYCEYCDRTFKSHELLYTHKIKKKHYTPKLHVPNSPDQEKTDNDGKDKALDNKQILNKLIEDVLKTLDVPVNRIMNNTNPTNSNNKENINPEKVSGISKVKTGVEMERADSGVNQSGTSEVPEKKRRGRKRKWPKNQSLKLKKFCSEVDDGFKYQCERCIKVFGTIVDLEAHREKEHAASFTCEECGQVLHSAKALLIHSRAHKSLKPYVCETCGRSYSQTSHLWQHMRFHQGIKPFACPHEGCEARYTIRPDLKDHIRKVHTRERPFRCTVCDKCFLTGSVYYQHRLIHTNDRRYGCDLCPKRFFRADALNNHRRIHTDERPYPCQVCGREFRQKGDRNKHLRTQHPDAIII

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01370124;
90% Identity
-
80% Identity
-