Basic Information

Gene Symbol
-
Assembly
GCA_958510785.1
Location
OY294016.1:22379651-22386423[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 3.6e-15 2.1e-11 43.6 0.2 9 70 262 321 257 325 0.87

Sequence Information

Coding Sequence
ATGGAGTCGGCCGACGTGAATGGCGGGAACGCCGAGGTGGCGCGCGACGAACCTAACCTAGAACCAATCCGATACGACGAAACAATGCCGGAGTCACAGCGCGAGCCGATCGACGACAATACGACGAGCAACGTCGTTAAGATGGAGGAGGGCGGCGAGGTGAACGGCGACGTTAAGAGCCCGAGGAAAAAGGGCACACCGGTTTTCAGGAGAAAGCTACGAAAGTTCAAGGCCAATTCGACGAGCAACGCCGAGACCGACGCGAAACCGCACACGAGAGGACAGAAGCGCAAAGTCTCGGAGCCCGACGATGTCAGCTCCGAGGACTCCACCGAATTCAATGGATTCGACACGCAGCTCATGGACACCGTCGAGCCCGGCACTCAGGTCCTCCAGAAACTCATCGCCGAAGCGGAATCGGCCGAGGCGCCGCAGGGCAAGAGGCGCAGACGCTCGACGTCCAAGATCTTCACCACCCTGAGAAATCTCGACGACAAGGAGGAGGACGACTTTGACGACGCGACGGACAATGCCGATTCGCACAAAACTAAGAGGGACAAGGAGTCCGACACGGACTCCATCGGCGTGCCGAACAGTTTAGACTCCGAAATGGATCCCCTgaaaacggacgaatcttccGCAAAGTCAGCTAACTCCTCCGCCAATAGCAGTCCCTCCGGTATCGGGCAGAAATTGAAAATAGCCAGAACGGTCAGGGTCATCAGTCCTGGAGGGgcgacgaaacaaaaaatttctgtAGACATGAGCAATCCGCTGTTCAGAGAACCTTTCAAGTATGGATGGAAGAGGGAACTGGTGTTCAGAGCCGGGTCGGAGCACGCCGTCAGGAGAATGGCCGATATATACTATTACACGCCAAAGGGCAAGAAAGTCAGGAGCTTTAGGGAGGTAGCGGAATTCTTGAATACGAAAGAATTGACGATAGACAACTTCACATTCTTCAAAGAGCCGCTCGGCGTTAACAATCCGGATTTCGAGATAATAAGAGACGCGAGAGTGAGAGACTCGACGGGGCCGGTACCAACACCGCCGAAGAAGCACGTGGCACCGAAAAAGACCCCGGCGAGAAAGAGCGTCGAGAAGCCTCTGACACCACCGCCTCCGGCTAAAGTCGCTGCGAAATCGCCGAAAGTCACACCGGCCAGTTTCAAAATAAAGCTTCCCGCCAAGAGGGGACAGCAAAAAAAAGAAGTCAGAAAGTCACCGCCGAAAGAGCCGGAGATGTTGCCACCTCAATGGAGTTCGCCCGCGACTACGAGGCGGAGTCAACCGGTCGTAGAAAAAACCCCACCGGCGAAGCCCAAGCGCGTGCTCAAGGCAAAACTTCAGGAACCCTGCAGCATACGATGTTCAACGAGTATGGGCCTTATACCGAGCTTACAGTGTTCTGTCTGCCTGTGCTTGTATCATCACGAATGCGTTGGCGATGTCGATAGAGCAGGCAGCGACGAATACGTCtgcaagAATTGTCACGAGGATTCTTCGAAAACTCAGCAGCATCAGCAAGTAGCTACAGTACCCCCGCCCCCTCCGTTAATACCGATAAGTATGATAAGCTCGCAAAATTCAAAGACTATTCACCCGACCGGTACGTCGCTGCCGAAGCTTCAGAGAATTCCAAAAGCCGACGGTGCGGAGACGAAAAAATCCACTAAAAGCTCGAACATTCCATCGAGGGCTTCGCCGAGCCCCGACAGAATGGACGGCTCGTGGTTGCAAGCGGGTAACGAGTTTCTTCACAGTCACGACGGGACGATACCAAAACCGGCGCAGAACATCGCGCTTATGGCGGGAAAACGTTACATCGTCGTGCCGAAGAACAACGCCATGGCTGTGCAGCCGGCCGTCACGGTCAGACCCGATAAGATCGGTGATAAAGCGCCAATGTTACCGGAGGCTTCGCACTCGGATATGTCGGCGGAGGACTCCAGCTCGCGGATCTCACCGAAGCCCACGAGCGAGATCGTCGCGCCGGCTGAGAGTTCCAATGGAAattcgaaagagagaccgcaAGTTGTCAGTCCGATGGAGACTGTGACTGAATTGGATGAGTCGATGGACGAAAGATCCAGCGTTGATACTCCAGAAACGAGAGACATCGTGGAAAATATTTGCACCGATGTTCACGAGAATTCGAAGCTCGAGGGGGATGCGAAAAACGAGGAAAATGAATTAGCCAATAGAGGGATCAATCCTGAAGCAACGATTGCAGAGTCTCCGGTTAATCCCGAGGAAACGGAAATAAAGATAATGGAAGTAGCGACAAATTCTGGCACGGTACAACCGGACAATGTTGAATTGAATTCCGATAGCATGCGAACGGAGGCTGTGGCTACGAATACTGTTTTTGTACAACCGGAGATTAAaaagaAAACTGCACCGATTGAGCCGGAACAGAGGCACTTCATGGTATCCGTTTGCGGTGGATACGACGCTCTTTCGCGGATCTTTCAGTACCTCAAAGTTCAAGAATTATTGCGAGCGGCTCGTGTGTGCAAAATGTGGCGAGATCTTGCGGCGCATTCTAATCTGTGGAAGACCGTGCGCATGAAGAACAGTCAAGTAACCGACTGGGACGGTCTGGCGGATTCTCTTAAGAGGCACGGCACTCAACACTTGGACTTGAGAAAAATGTTGGTCGCCGGTGAATCGGACGGtatctggaaaaaattcgttactGTCATACCGCGTGTTACGAGTCTGGTGAAGCTCGAACTCTGTCGCTGTCCCGTAATGGTCGTGGAGGAGGTAATCAAGAGTTGTCCACAGCTCGAAGTATTGAGCGCTATGTCGATAAAATGCGACTCGCTGAATCTTGAATCCGTTGGAAATCTCAAATCGTGTCAAGAGCTGAGGCTAAAAGCTATAAGCGGCATGTCGTTGCACGGAGATCTCTCGCCGCTTCAAGAACTCACACAACTTACGCATCTGAGTTTGACGTCAGTGAAAGAATTGGGCAAGAAGAAAGTGGACGTACTGGCGTCGTTGATAAATCTCGAGACCCTCGAGCTCGGCGAGTGTTCGGACTTCCCGGACAAATTCGGTACCGCTGTTTTGTTGAAACTCGAAAAACTGGAGCGTCTCAGGCTTGAGAAGGGTCAGGGCACGTGTTGCACATTCGACATACTCGAGGGTGTCTCGAAGCTGGAGACTCTCAGTCAACTGGAACTCGTCAATTTCGACGTGAAAAACGGGTTCGACAAGTGTCTCTCGAATTGCAAGAATATCAAGAGGCTGCTTATCATTCCGACTTACATATCGCAGTCGGCGACCTCGAACAACATGGTGCTGGGCGGTGTCACGGAACTGTCGAACAACTTGACGCATTTCGTATGGGGCGTGACGCTCGAGTTACTCAGAGTTACCGAACTTTTCGTCGATCAATGCAATCAGATGAACAAACAGGTTACCGGAGACTCCATACCGGTGTTAAAACCGGTGCCGTGCTTAAAACTCATCGAGGACGTCGAGGAAGATCCCGATCTTCTCAAAGACGAGAAGCCACAGCCGAACCTGACGAACCCGCAGGTGGATATTCTGCCTTTGCCGCAGTTGCAAAAGCTTCTTCTCACGGCGTTGCCAAAGACGCGAGTCAAGATTCTGAAGATACCTTTCCACGCTACCTGGCGTCAGAGCATATCGGACACGACGACGCAATAA
Protein Sequence
MESADVNGGNAEVARDEPNLEPIRYDETMPESQREPIDDNTTSNVVKMEEGGEVNGDVKSPRKKGTPVFRRKLRKFKANSTSNAETDAKPHTRGQKRKVSEPDDVSSEDSTEFNGFDTQLMDTVEPGTQVLQKLIAEAESAEAPQGKRRRRSTSKIFTTLRNLDDKEEDDFDDATDNADSHKTKRDKESDTDSIGVPNSLDSEMDPLKTDESSAKSANSSANSSPSGIGQKLKIARTVRVISPGGATKQKISVDMSNPLFREPFKYGWKRELVFRAGSEHAVRRMADIYYYTPKGKKVRSFREVAEFLNTKELTIDNFTFFKEPLGVNNPDFEIIRDARVRDSTGPVPTPPKKHVAPKKTPARKSVEKPLTPPPPAKVAAKSPKVTPASFKIKLPAKRGQQKKEVRKSPPKEPEMLPPQWSSPATTRRSQPVVEKTPPAKPKRVLKAKLQEPCSIRCSTSMGLIPSLQCSVCLCLYHHECVGDVDRAGSDEYVCKNCHEDSSKTQQHQQVATVPPPPPLIPISMISSQNSKTIHPTGTSLPKLQRIPKADGAETKKSTKSSNIPSRASPSPDRMDGSWLQAGNEFLHSHDGTIPKPAQNIALMAGKRYIVVPKNNAMAVQPAVTVRPDKIGDKAPMLPEASHSDMSAEDSSSRISPKPTSEIVAPAESSNGNSKERPQVVSPMETVTELDESMDERSSVDTPETRDIVENICTDVHENSKLEGDAKNEENELANRGINPEATIAESPVNPEETEIKIMEVATNSGTVQPDNVELNSDSMRTEAVATNTVFVQPEIKKKTAPIEPEQRHFMVSVCGGYDALSRIFQYLKVQELLRAARVCKMWRDLAAHSNLWKTVRMKNSQVTDWDGLADSLKRHGTQHLDLRKMLVAGESDGIWKKFVTVIPRVTSLVKLELCRCPVMVVEEVIKSCPQLEVLSAMSIKCDSLNLESVGNLKSCQELRLKAISGMSLHGDLSPLQELTQLTHLSLTSVKELGKKKVDVLASLINLETLELGECSDFPDKFGTAVLLKLEKLERLRLEKGQGTCCTFDILEGVSKLETLSQLELVNFDVKNGFDKCLSNCKNIKRLLIIPTYISQSATSNNMVLGGVTELSNNLTHFVWGVTLELLRVTELFVDQCNQMNKQVTGDSIPVLKPVPCLKLIEDVEEDPDLLKDEKPQPNLTNPQVDILPLPQLQKLLLTALPKTRVKILKIPFHATWRQSISDTTTQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2