Basic Information

Insect: Euzophera pinguis
Gene Symbol: PAX6
Assembly: GCA_947363495.1
Location: OX376160.1:10689038-10737365[-]

Transcription Factor Domain

TF Family: PAX
Domain: PAX domain
PFAM: PF00292
TF Group: Helix-turn-helix
Description: The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 4.8e-35 1.4e-31 109.7 0.0 23 125 77 174 66 174 0.92

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	4.8e-35	1.4e-31	109.7	0.0	23	125	77	174	66	174	0.92

Sequence Information

Coding Sequence: ATGTTGATATCGGCGGGCAGCGGCCCCACGCCTGATTTTTCCCCTGCCTCGTGCTGCGCCTCTTGGAAAATGGAACCGGCGCCGCCCGCGCCTGCTCTCTCGCAAACCCTCAATCTTTCGCCCAACGTGCCTGTATCTCCGTCATCGTCCGGGGGCGGCGCTGGCGGCGGCAGCGGAACCCCTCTCTACCCCGGCGCGGCGTCTCACCCTCTTTCGTCCCTGCTATCCCAGCAGAGACTTCTGGAGCTCTCCAGATTTGGCCTGAGGCACTACGACATCGCTCATCATGTGCTGTCTCAGCAAGGTGCTGTTACCAAACTGCTTGGCACTCTCCGACCCCCAGGCCTTATCGGTGGAAGCAAGCCTAAGGTAGCAACACCGGCAGTAGTATCCAAGATAGAGCAATACAAGAGGGAAAACCCTACGATCTTCGCGTGGGAGATCCGTGAGCGACTCATCTCAGAAGGTGTATGCACAAACGCAACAGCGCCAAGCGTCTCGTCAATCAACAGGATACTAAGAAATAGAGCCGCTGAAAGAGCAGCAGCTGAATTTGCGAGAGCAGCGGGCTATGGGCTGTATGCCGCGCCGCCTCCATACGGAGCCTTTCCCTGGGCCGGCGGCGGCGGAGTGTGGCCTCCGGGATCCTTGCCGTTGCCGCCAGGAGTACCGCCGTCGTCGGGAGTACCTCACCCCGATGCTATGCAGCAAGGCTTCTTGTCATCTGGTCGAGGGCTTATTGATGTCGACGGTGATGACTCTGGCTCGTTAGATGGCGAACAACCAAAGTTTCGACGTAATCGTACTACCTTCAGTCCCGATCAACTGGAAGAATTAGAGAAAGAATTCGAAAAATCTCATTATCCGTGTGTGTCGACACGAGAAAGGCTCGCATCAAAAACATCTTTATCGGAAGCGCGCGTACAGGTTTGGTTTTCCAACAGACGAGCCAAGTGGAGACGCCACCAGCGCATGAACCTCCTGAAGCGCGGTGGCGGCTCGCCCCCGCACCGCCTCCCCCACTCCCCCTCCCGATCCCGTTCGCGTTCTTTGTCCCCCGCACGCGTCCCCTATCACACCCCACAGATGGGCGGCGAAAATAGTGCGTTCAAAGCACTACATCAAGATACCAATGCCCTGAAAGCACTGTCGCATCAAGCACAATTCGATAGTAATGCCCTGAAGGCTTTGTCGCAACATAATTTTGAAAGCGGAGCTTTTAAACCGCATCCGGCACTAGAGAACAGTGCTTTTAAAGCACTCGTACCTCATTCTGCAGCAGCGGCGTTGTTAGCAGCACAGTCCATCCAGCTAGCTCGTGGCTGTGAATCGAATTCGGACTCTGATGAAGAAATCAATGTGCACGACGAGAGCGATGATGAAAGCGAAAGACAGAGAAGCAAAGCTAGATCAGTGTCGCCAAGTCCCAGCGACCGACGGCCGCCCGCGAGCGATCTACCTTTACAACTCACTAAACACGATCGTTGA
Protein Sequence: MLISAGSGPTPDFSPASCCASWKMEPAPPAPALSQTLNLSPNVPVSPSSSGGGAGGGSGTPLYPGAASHPLSSLLSQQRLLELSRFGLRHYDIAHHVLSQQGAVTKLLGTLRPPGLIGGSKPKVATPAVVSKIEQYKRENPTIFAWEIRERLISEGVCTNATAPSVSSINRILRNRAAERAAAEFARAAGYGLYAAPPPYGAFPWAGGGGVWPPGSLPLPPGVPPSSGVPHPDAMQQGFLSSGRGLIDVDGDDSGSLDGEQPKFRRNRTTFSPDQLEELEKEFEKSHYPCVSTRERLASKTSLSEARVQVWFSNRRAKWRRHQRMNLLKRGGGSPPHRLPHSPSRSRSRSLSPARVPYHTPQMGGENSAFKALHQDTNALKALSHQAQFDSNALKALSQHNFESGAFKPHPALENSAFKALVPHSAAAALLAAQSIQLARGCESNSDSDEEINVHDESDDESERQRSKARSVSPSPSDRRPPASDLPLQLTKHDR

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00720036; iTF_00843329; iTF_01508034; iTF_01078023; iTF_01079724; iTF_00985070; iTF_00843503; iTF_01506996; iTF_01507189; iTF_01079863; iTF_01507896; iTF_00984857; iTF_01078176; iTF_00114767; iTF_00114916; iTF_00770933; iTF_00771053; iTF_01280247; iTF_01280013; iTF_01281135; iTF_01561978; iTF_00357249; iTF_00358533; iTF_01151180; iTF_00358350; iTF_01076463; iTF_01151056; iTF_00357461; iTF_01076218; iTF_00801628; iTF_00801821; iTF_01561853; iTF_00710175; iTF_00710017; iTF_00985823; iTF_00986026; iTF_01528258; iTF_01529026; iTF_01529163; iTF_01528112; iTF_01179460; iTF_01179334; iTF_01180158; iTF_01429767; iTF_00077317; iTF_00818986; iTF_00077453; iTF_00820045; iTF_00761456; iTF_00819889; iTF_01429907; iTF_00761652; iTF_00859292; iTF_00819136; iTF_01312196; iTF_01312076; iTF_00113296; iTF_00113171; iTF_01403270; iTF_00275237; iTF_00275080; iTF_01403403; iTF_00178129; iTF_00177904; iTF_00235830; iTF_00236481; iTF_00236601; iTF_00235709; iTF_00433120; iTF_00432965; iTF_00276105; iTF_00276386; iTF_00825417; iTF_00044291; iTF_00825708; iTF_00044471; iTF_00666506; iTF_00666339; iTF_00022762; iTF_00022625; iTF_01170570; iTF_01171440; iTF_01170397; iTF_01171294; iTF_00119569; iTF_00119437; iTF_00267155; iTF_00267011; iTF_00909684; iTF_00909577; iTF_00686166; iTF_00686317; iTF_00856598; iTF_00856431; iTF_01161144; iTF_01161324; iTF_00632729; iTF_00632591; iTF_00361597; iTF_00361441; iTF_00968000; iTF_00967880; iTF_00006251; iTF_00006120; iTF_00284355; iTF_00034532; iTF_00034703; iTF_00035471; iTF_00035632; iTF_00284511; iTF_00649067; iTF_00648939; iTF_01124429; iTF_01124564; iTF_01125275; iTF_01125437; iTF_00364896; iTF_01335757; iTF_01335907; iTF_00701008; iTF_00700835; iTF_00698248; iTF_00696325; iTF_00699141; iTF_00704784; iTF_00698099; iTF_00701941; iTF_00705973; iTF_00704982; iTF_00705815; iTF_00701784; iTF_00699930; iTF_00700091; iTF_00699006; iTF_00696448; iTF_00842480; iTF_00842637; iTF_01033706; iTF_01033551; iTF_01034363; iTF_01034560; iTF_01336656; iTF_01336814; iTF_00063410; iTF_00063558; iTF_00074482; iTF_00074305; iTF_00467282; iTF_00468145; iTF_00468021; iTF_00467382; iTF_00682196; iTF_00682380; iTF_00634454; iTF_00634145; iTF_00681494; iTF_00681618; iTF_00638615; iTF_00638481; iTF_01182839; iTF_01182499; iTF_00075288; iTF_00076503; iTF_00075482; iTF_00076286; iTF_01333560; iTF_01333771; iTF_00323321; iTF_00323480; iTF_00723801; iTF_00723928; iTF_01083129; iTF_01083298; iTF_00157035; iTF_00280965; iTF_00281226; iTF_00823761; iTF_00157177; iTF_00823872; iTF_00406714; iTF_00406540; iTF_00683290; iTF_00683151; iTF_00811002; iTF_00810827; iTF_01020250; iTF_01020054; iTF_00278939; iTF_00279084; iTF_01208155; iTF_01207941; iTF_01099804; iTF_01099701; iTF_01334812; iTF_01334585; iTF_00055230; iTF_00055386; iTF_00697310; iTF_00697157; iTF_01041726; iTF_01041572; iTF_00162335; iTF_00162734; iTF_01544708; iTF_01543905; iTF_01546472; iTF_01543728; iTF_01544848; iTF_01545591; iTF_01545720; iTF_01546618; iTF_01173247; iTF_01173109; iTF_01367519; iTF_01367877; iTF_01560959; iTF_01561090; iTF_00382400; iTF_00382576; iTF_01172160; iTF_01172333; iTF_01193440; iTF_01193561; iTF_01341248; iTF_01340978; iTF_01302117; iTF_00012994; iTF_00640293; iTF_01302309; iTF_00026822; iTF_00640107; iTF_00072559; iTF_00026674; iTF_00647826; iTF_00072789; iTF_00647963; iTF_00012764;
90% Identity: iTF_01429767;
80% Identity: iTF_00720036;