Basic Information

Gene Symbol
Gzf1
Assembly
GCA_018420115.1
Location
JAFFZH010014206.1:60108-62238[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 19 1.1e-06 0.00012 22.9 0.5 1 23 18 40 18 40 0.98
2 19 8e-06 0.00089 20.2 4.1 1 23 46 68 46 68 0.99
3 19 0.0028 0.31 12.2 0.1 1 23 74 96 74 96 0.98
4 19 2.3e-05 0.0025 18.7 0.9 1 23 102 124 102 125 0.95
5 19 0.0005 0.056 14.5 3.0 1 23 135 158 135 158 0.96
6 19 0.00025 0.028 15.5 0.4 1 23 167 189 167 189 0.95
7 19 1.2e-07 1.3e-05 25.9 1.8 2 23 196 217 196 217 0.98
8 19 4.6e-05 0.0051 17.8 2.0 1 23 223 245 223 245 0.97
9 19 2.8e-05 0.0031 18.5 2.8 1 23 251 273 251 273 0.99
10 19 0.062 6.9 7.9 0.3 3 23 316 337 315 337 0.97
11 19 0.00012 0.014 16.4 0.9 1 23 343 366 343 366 0.98
12 19 0.0047 0.52 11.5 2.9 2 23 372 394 371 394 0.96
13 19 1e-05 0.0011 19.9 0.5 1 23 400 422 400 422 0.97
14 19 0.00045 0.049 14.7 1.3 2 23 429 451 428 451 0.96
15 19 7.9e-05 0.0087 17.1 2.7 1 23 466 489 466 489 0.93
16 19 0.0087 0.96 10.6 0.2 1 23 501 523 501 523 0.95
17 19 0.0087 0.97 10.6 3.6 1 23 529 551 529 551 0.94
18 19 9.6e-08 1.1e-05 26.2 1.4 1 23 557 579 557 579 0.98
19 19 6.7e-05 0.0075 17.3 0.3 1 21 585 605 585 606 0.95

Sequence Information

Coding Sequence
ATGACCAAACTCATAGAACACTTGAAAAATGTACACGGAATAGAGAGAGCCTTCAAATGCGACGAGTGCGGAAAGGCTTTCAGAAGTCCTATGAACATAAAGAGACACAAACTCATTCACACTGGGTTGAAAAAATACACCTGCGATGTTTGCGATTACACTTGCAACCAGAAAACGAATTTGGAAAATCACAGGAGACGACACGCCAAGGATTACGCATACGAGTGCGAAGTTTGCGACAAGGGTTTTCTTTCGAAGGCGGACTATGTCGAGCACAAAAATGTACATGCGGGAAAAAAACCCTACGCCTGTGAACTCTGCCCAAAGTCTTATCCCTACAAGAATAATTTACTCATTCACAAGAGAATCCATCATCCCGGTTTACTCAAAGCCGTGGACAGCCACAATTGCTCTATGTGCTCGGCGAATTTTCCTTACAAACGGCTCTTGACTCGGCACATGAAGTCTCAACACGGACTAGAACAGAGTTTGAAAAAATTTCTATGCGATTTTTGTGGGAAGCAAGTATCTTCCCAGAGCGTTTTGATCAGTCACAGGAGGATTCACACCGGGGAAAAACCGGCTACCTGCGAATTGTGCGGGAAACAATTTAGTACCAAAGAAAATTTGAAACTCCATCAACGAACGCATACGGGGGAAAAACCTCACGTTTGTTTACAATGCGGCAAGGGTTTCACCCAAAGAACTTCGCTCGTTCTTCACACGCGGTATCACACCGGACAAAGACCTTACCAATGCGACGTTTGCAAGAAGGGTTTTATCTCGAACACGTTCTTGAAGAAGCACAAAAAATCTCATGACCATCCTGTTCCCCACCAGTGGCCCCTGGGCCAACAACAATCCGGAGAAAACGTTATGGTGAGAGTCAAGACGGAAAACGCCCCTGTGCCTGCGGAAGAGAAATCCGACAGCAACGTGAAGGCTTGCGAAATATGCAACGAACAGTTTCATTTTGTAACGAGGCTGGTAGCTCATCTGAGAATAGAACACGGGATCCAGAGGCCTTTCAAATGCGGTACATGCTGGCGGACTTACGCCCAGCAATTCATGCTCAATGCGCACGTTAAAAAATCTCACACACCAAAGAACGTGTCCTGCGATCGTTGCAAATTCACGTGTGTCTCAAACGCGGATTTGGAGAGGCACAGGAAAAAGCAACACGAGCCCAAAATAAAATTTTACTGCGATGTGTGCGGTCAGACGTTTACGGACAAGGAAACTTTTTCAGCTCACACAGCTATGCATAACTTCATGGAATATCAACAGTGCGTTACCTGCGGTACAACTTTTAACGACGTCGAATCGTTGAAGGAACACCACAGACTGTATCATTTCGATGCTGCGGCAGCGGCCGAAATGGAGGGAGAAGCTGCCCACAAATGCGACGAGTGTGGAAAGAGTTACAAGTTCAAGTCCGTTCTTAAACAGCATAAAATCAACGTTCACAGCGCCCCCAATTACGAGAGACCGAAACGGAGGTTTCTCTGCGCTCTGTGTGGCAAAGAACTAAAGACAGCTAAGGGATTTGAGATACACAACCGTTCCCACACAGGAGAGAAACCGTACACCTGCGAGGTATGCGGGAAATGCTTCGCATGTGAGACTCTGCTGAGAACTCACAACGTCACTCATACCGGAGAGAGAAAATATACGTGCGACGAATGCGGTAAATCGTTTACACAAAGATCCACGCTCGTCGTTCACAAGAGATATCACACAGGCGAGAGGCCGTACGTTTGTCAAAAATGCGGCAAGGGTTTCGTCACTAGAACCGTCCTTAATACTCACCTGAAATCCTGCCGCTGA
Protein Sequence
MTKLIEHLKNVHGIERAFKCDECGKAFRSPMNIKRHKLIHTGLKKYTCDVCDYTCNQKTNLENHRRRHAKDYAYECEVCDKGFLSKADYVEHKNVHAGKKPYACELCPKSYPYKNNLLIHKRIHHPGLLKAVDSHNCSMCSANFPYKRLLTRHMKSQHGLEQSLKKFLCDFCGKQVSSQSVLISHRRIHTGEKPATCELCGKQFSTKENLKLHQRTHTGEKPHVCLQCGKGFTQRTSLVLHTRYHTGQRPYQCDVCKKGFISNTFLKKHKKSHDHPVPHQWPLGQQQSGENVMVRVKTENAPVPAEEKSDSNVKACEICNEQFHFVTRLVAHLRIEHGIQRPFKCGTCWRTYAQQFMLNAHVKKSHTPKNVSCDRCKFTCVSNADLERHRKKQHEPKIKFYCDVCGQTFTDKETFSAHTAMHNFMEYQQCVTCGTTFNDVESLKEHHRLYHFDAAAAAEMEGEAAHKCDECGKSYKFKSVLKQHKINVHSAPNYERPKRRFLCALCGKELKTAKGFEIHNRSHTGEKPYTCEVCGKCFACETLLRTHNVTHTGERKYTCDECGKSFTQRSTLVVHKRYHTGERPYVCQKCGKGFVTRTVLNTHLKSCR

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00718799;
90% Identity
iTF_00718799;
80% Identity
-