Basic Information

Transcription Factor Domain

TF Family: LRRFIP
Domain: LRRFIP domain
PFAM: PF09738
TF Group: Unclassified Structure
Description: LRRFIP1 is a transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'- AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA [1]. LRRFIP2 may function as activator of the canonical Wnt signalling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin [2].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 6.2e-80 8.6e-76 255.7 17.8 89 300 6 216 3 216 0.96

2 3 0.0051 70 3.2 2.6 122 171 216 265 214 268 0.91

3 3 0.079 1.1e+03 -0.7 6.0 194 238 247 290 235 291 0.59

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	6.2e-80	8.6e-76	255.7	17.8	89	300	6	216	3	216	0.96
2	3	0.0051	70	3.2	2.6	122	171	216	265	214	268	0.91
3	3	0.079	1.1e+03	-0.7	6.0	194	238	247	290	235	291	0.59

Coding Sequence: ATGAAACACTTATTTCAGTTAGAACTTAAGGAATTTGAAGAAAAATTCCGCAAAGCTATGATAACTAACGCGCAATTGGATAATGAGAAGTCAACTTATTCGTATCAAGTAGATCTATTGAAAGACAAACTGGAAGAATTGGAGGAAACAACGGCTCAATTGCGAAGAGAGCTTAGAGAAAAAAATCGAGAAGCTGAACAGCTGAAACGAGTGAGTCAACGGCTTAAAGAAGACCTCGACGTCTGCAGGGTTCAGCTAATCGAACGAGACACGCTAATACAGGAAAATGGTCTCGTCATAGTCGAGGACGAGGGCGACGAGAACGATCCGGATATTGCAGAAAACGGTCCCCGTCCAAGAAAGAGAGTCCTAGTCACTACCGAAGGCGCAGACTTGCTGCAAAATGCTGGTGAAGGCTCGTTAGATGTCCGGCTCAGAAGGTTTGCGTCCGAGAAGAAAGAACTACAAGACGAAATTCGGCATTTGCGGCTCGAACTGGAGGACGCGAAGAATCGTGTGAGATCGGACAGGCTCCCAGGCTCGACGTTAGGAAACTTGTCAGACTCTGAGGATATTCAGCGCGAGGCGAACAAGCATTTATCAGATTATAAATTCAAGTTGCAAAAAGCAGAACAGGACATGTCGACGCTTCAGGCGACGGTAGCGAGGCTTGAGAGTCAAGTTATTCGGTATAAATCTGCGGCAGAGGCTTCCGAGAAGGCGGAAGACGAGCTTAAGGTCGAGAAGCGGAAGTTGCAGCGAGAGGTACGAGAATCACAGGGTCGAGTGGAAGAACTTGAAACAGCGAATTCCCACTTACAACGAAGGCTAGATAAACTTAAAAACGCCAAGTCTGCACTTCTCAAAGAACTTTGA
Protein Sequence: MKHLFQLELKEFEEKFRKAMITNAQLDNEKSTYSYQVDLLKDKLEELEETTAQLRRELREKNREAEQLKRVSQRLKEDLDVCRVQLIERDTLIQENGLVIVEDEGDENDPDIAENGPRPRKRVLVTTEGADLLQNAGEGSLDVRLRRFASEKKELQDEIRHLRLELEDAKNRVRSDRLPGSTLGNLSDSEDIQREANKHLSDYKFKLQKAEQDMSTLQATVARLESQVIRYKSAAEASEKAEDELKVEKRKLQREVRESQGRVEELETANSHLQRRLDKLKNAKSALLKEL

Sequence clustering based on sequence similarity using MMseqs2