Basic Information

Gene Symbol
AAEL000794
Assembly
GCA_951802225.1
Location
OX637654.1:6128564-6133262[+]

Transcription Factor Domain

TF Family
PAX
Domain
PAX domain
PFAM
PF00292
TF Group
Helix-turn-helix
Description
The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 7 0.067 1.3e+02 3.0 0.0 27 81 192 246 179 252 0.86
2 7 0.1 2e+02 2.4 0.0 30 81 246 297 241 302 0.86
3 7 0.091 1.8e+02 2.6 0.0 29 81 296 348 290 353 0.86
4 7 0.08 1.6e+02 2.7 0.0 28 81 346 399 339 405 0.87
5 7 0.11 2.2e+02 2.3 0.0 31 81 400 450 395 456 0.86
6 7 0.077 1.5e+02 2.8 0.0 28 81 448 501 440 507 0.86
7 7 0.086 1.7e+02 2.6 0.0 29 81 500 552 494 558 0.86

Sequence Information

Coding Sequence
ATGGAAGCTGTCATCGAAAAGCAtaaactacaaaaaatatcACTTATGAGGTCGTTCTGCCTGAAGACGGGCCTGCAGCTGCTGCTGCGCGAGTACGACTTCGACAGCCGGCACCGGCCGGCCTTCTGCGGCGCCGACGTCATGAACATCTTCCCCGTCGTCAAACATATCAACCCGAGGGCATCGGACGCGTACAACTTCTACACTACGGGCCAGAGCAAGATCCAAGCGGGCGCGGTGACGGAGGGGCACGAGCTGATCGCAGAGGCGCTCAACCTTCTGAACAACGTGTACGGCGCCATGCACGGCGAGATCGCGCAGTGCCTGCGCATGGTGGCGCGCCTCTGCTACGTGACCGGCGAGCACCGCGACGCCATGGCTTACCAGCAGAAGGCCGCGCTCATGTCGGAGCGCGTCAATGGGATCGATCATCCGTATACTATAACTGAATATTCTCACCTGGCGCTGTACTGCTTCGCCAACGGGCAGGTGAGCACGGCGCTCAAGCTGCTGTACCGCGCGCGCTACCTGGCGCTGCTCGTGTGCGGCGAGCGGCATCCCGAGGTGGCGCTGCTCGACGTGAGTACTACTACACTTACACTCTGTGTCCTTACTGAACTTAGTAAAGTTCGCAACGGGCAGGTGAGCACGGCGCTCAAGCTGCTGTACCGCGCGCGCTACCTGGCGCTGCTCGTGTGCGGCGAGCGGCATCCCGAGGTGGCGCTGCTCGACGTGAGTACTACTACACTTACACTCTGTGTCCTTACTGAACTTAGTAAAGTTCGCAACGGGCAGGTGAGCACGGCGCTCAAGCTGCTGTACCGCGCGCGCTACCTGGCGCTGCTCGTGTGCGGCGAGCGGCATCCCGAGGTGGCGCTGCTCGACGTGAGTACTACTACACTTACACTCTGTGTCCTTACTGAACTTAGTAAAGTTCGCAACGGGCAGGTGAGCACGGCGCTCAAGCTGCTGTACCGCGCGCGCTACCTGGCGCTGCTCGTGTGCGGCGAGCGGCATCCCGAGGTGGCGCTGCTCGACGTGAGTACTACTACACTTACACTCTGTGTCCTTACTGAACTTAGTAAAGTTCGCAACGGGCAGGTGAGCACGGCGCTCAAGCTGCTGTACCGCGCGCGCTACCTGGCGCTGCTCGTGTGCGGCGAGCGGCATCCCGAGGTGGCGCTGCTCGACGTGAGTACTACTACACTTACACTCTGTGTCCTTACTGAACTTAGTAAAGTTCGCAACGGGCAGGTGAGCACGGCGCTCAAGCTGCTGTACCGCGCGCGCTACCTGGCGCTGCTCGTGTGCGGCGAGCGGCATCCCGAGGTGGCGCTGCTCGACGTGAGTACTACTACACTTACACTCTGTGTCCTTACTGAACTTAGTAAAGTTCGCAACGGGCAGGTGAGCACGGCGCTCAAGCTGCTGTACCGCGCGCGCTACCTGGCGCTGCTCGTGTGCGGCGAGCGGCATCCCGAGGTGGCGCTGCTCGACGTGAGTACTACTACACTTACACTCTGTGTCCTTACTGAACTTAGTAAAGTTCGCAACGGGCAGGTGAGCACGGCGCTCAAGCTGCTGTACCGCGCGCGCTACCTGGCGCTGCTCGTGTGCGGCGAGCGGCATCCCGAGGTGGCGCTGCTCGACGTGAGTACTACTACACTTACACTCTGTGTCCTTACTGAACTTAGTAAAGTTCGCAACGGGCAGGTGAGCACGGCGCTCAAGCTGCTGTACCGCGCGCGCTACCTGGCGCTGCTCTTAAGCCCCCTAAttctaatttaa
Protein Sequence
MEAVIEKHKLQKISLMRSFCLKTGLQLLLREYDFDSRHRPAFCGADVMNIFPVVKHINPRASDAYNFYTTGQSKIQAGAVTEGHELIAEALNLLNNVYGAMHGEIAQCLRMVARLCYVTGEHRDAMAYQQKAALMSERVNGIDHPYTITEYSHLALYCFANGQVSTALKLLYRARYLALLVCGERHPEVALLDVSTTTLTLCVLTELSKVRNGQVSTALKLLYRARYLALLVCGERHPEVALLDVSTTTLTLCVLTELSKVRNGQVSTALKLLYRARYLALLVCGERHPEVALLDVSTTTLTLCVLTELSKVRNGQVSTALKLLYRARYLALLVCGERHPEVALLDVSTTTLTLCVLTELSKVRNGQVSTALKLLYRARYLALLVCGERHPEVALLDVSTTTLTLCVLTELSKVRNGQVSTALKLLYRARYLALLVCGERHPEVALLDVSTTTLTLCVLTELSKVRNGQVSTALKLLYRARYLALLVCGERHPEVALLDVSTTTLTLCVLTELSKVRNGQVSTALKLLYRARYLALLVCGERHPEVALLDVSTTTLTLCVLTELSKVRNGQVSTALKLLYRARYLALLLSPLILI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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