Eocc000973.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Eurois occulta
Gene Symbol
foxf1-a
Assembly
GCA_950022335.1
Location
OX465477.1:16299479-16300228[-]

Transcription Factor Domain

TF Family
Fork_head
Domain
Fork_head domain
PFAM
PF00250
TF Group
Helix-turn-helix
Description
The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 1.1e-39 2e-36 125.1 0.0 1 87 22 107 22 108 0.97

Sequence Information

Coding Sequence
ATGAAGACCGAGGACCAAACCACGGAGGAGGCGGCGCGCCGCGCGCCCGCCACCCGCAGACAAGAAAAACCACCCTTTTCCTACATCGCCCTCATAGTTATGGCCATACGACATTCGCCAAACAAAAGGCTGACGCTCAGCGAGATATACGCGTTCCTCCAACAACAGTTCCCGTTCTTCCGCAGCTCCTATCAGGGCTGGAAGAACTCTGTTCGccataatttaagtttaaacGAATGTTTCGTGAAGTTACCGAAGGGGCTGGGCAGGCCAGGCAAGGGTCACTACTGGACGATCGATCCATCATCCGAGTTCATGTTCGAGGAAGGTTCGTTTAGAAGAAGACCGCGCGGTTTCCGTCGGAAGTGTCAAGCGTTGAAGCCTCAGTTCGGGAGCGGAAGTTATCTCTGCGGCGGTGGAGTGCCGTCGCTGCCACCGTCGCAGCCGACGGGCTACGAGCTGGCGGGCGGCAGCGGTAcgggcgccggcggcggcggctccATCGACTACGGGGCGTGCGCGTACTCGCACGCGAGCCCGGGCCAGCAGTTGGCGTACGGCGGCGAGTATTGCGCGTACGGCGCCATCAACGAACGCGAGTGGCCGCTGGCGTACGGCGGCGTGGACGCGGGCTACCGGCCGCCGCCTACCTCGCCACCGCCGCACCACGACCTGCCCGACCTCATCCCCAACTACCAGTATGCTGTGGCCAATGAACATGGTGAGTTTAACATCATTTACATTTCATAA
Protein Sequence
MKTEDQTTEEAARRAPATRRQEKPPFSYIALIVMAIRHSPNKRLTLSEIYAFLQQQFPFFRSSYQGWKNSVRHNLSLNECFVKLPKGLGRPGKGHYWTIDPSSEFMFEEGSFRRRPRGFRRKCQALKPQFGSGSYLCGGGVPSLPPSQPTGYELAGGSGTGAGGGGSIDYGACAYSHASPGQQLAYGGEYCAYGAINEREWPLAYGGVDAGYRPPPTSPPPHHDLPDLIPNYQYAVANEHGEFNIIYIS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00017154; iTF_01151874; iTF_01062564; iTF_00147109; iTF_00850405; iTF_01029028; iTF_00771685; iTF_01027110; iTF_00851528; iTF_01029969; iTF_01230321; iTF_00951604; iTF_00299961; iTF_00888027; iTF_00973531; iTF_01025790; iTF_01030944; iTF_00383430; iTF_01119088; iTF_00808913; iTF_00809868; iTF_00176917; iTF_01118065; iTF_00111412; iTF_01116982; iTF_01302100; iTF_00640091; iTF_01063559; iTF_01491688; iTF_01332356; iTF_01028073; iTF_01180137; iTF_01073417; iTF_01179314; iTF_01501897; iTF_00706754; iTF_01360419; iTF_01166405; iTF_00637287; iTF_00822697; iTF_00823735; iTF_01197532; iTF_01435870; iTF_00042442; iTF_00039603; iTF_00041589; iTF_00040604; iTF_00043293; iTF_00374986; iTF_00726096; iTF_00036433; iTF_00622621; iTF_00889002; iTF_00237276; iTF_00907690; iTF_00449932; iTF_00000993; iTF_00446927; iTF_01361391; iTF_01259888; iTF_01084947; iTF_01538549; iTF_00444919; iTF_00685241; iTF_00185950; iTF_00448830; iTF_00000127; iTF_00445919; iTF_00932228; iTF_00824519; iTF_01342030; iTF_00171569; iTF_01377281; iTF_01424857; iTF_00390193; iTF_01092876; iTF_01285356; iTF_01246637; iTF_01534605; iTF_00300979; iTF_00441294; iTF_01264209; iTF_01076196; iTF_00037586; iTF_00924402; iTF_01429746; iTF_00928469; iTF_00301910; iTF_01061691; iTF_00906870; iTF_01094710; iTF_01093849; iTF_00142905; iTF_00373721; iTF_00931033; iTF_01338298; iTF_01339767; iTF_01064444; iTF_01336636; iTF_00172541; iTF_00745437; iTF_00063390; iTF_00363838; iTF_01531774; iTF_00757951; iTF_00830976; iTF_01489952; iTF_00236460;
90% Identity
iTF_00000127;
80% Identity
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