Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 4.3e-05 1.2 9.9 0.0 24 49 11 36 5 39 0.90

2 6 0.00021 5.8 7.7 1.5 21 49 91 119 77 125 0.90

3 6 0.0012 33 5.3 0.0 21 48 148 175 140 181 0.84

4 6 0.012 3.2e+02 2.1 0.1 21 47 204 230 196 235 0.78

5 6 5.4e-05 1.5 9.6 0.0 22 52 233 263 220 265 0.86

6 6 0.0099 2.7e+02 2.4 0.1 23 46 262 282 258 290 0.72

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	4.3e-05	1.2	9.9	0.0	24	49	11	36	5	39	0.90
2	6	0.00021	5.8	7.7	1.5	21	49	91	119	77	125	0.90
3	6	0.0012	33	5.3	0.0	21	48	148	175	140	181	0.84
4	6	0.012	3.2e+02	2.1	0.1	21	47	204	230	196	235	0.78
5	6	5.4e-05	1.5	9.6	0.0	22	52	233	263	220	265	0.86
6	6	0.0099	2.7e+02	2.4	0.1	23	46	262	282	258	290	0.72

Coding Sequence: ATgcacatacaaacacacaaaacaaAGAAAACCTTCACCTGCATACTAtgcaaagaaatatttaaacagaatAAGGATCTAATTACACATTTAAGTGAAAAACACTTTGAAGGTGACAAATTTAAGTGTAATCTTTGTGATAGTGCCTTTGATAGTgtgaaattgttaaaaaaacactttatagtGCATAATGAGAAGTTTAAGTGTAGTTTTTGTGATAAAGACTTCGCCAAAAAGAAAGGATTGAAGGAACATTTAAAAGTGCATACCGGTGAAAGGCCCTATATTTGCGACATATGCGGCCGCTGTTTCCCCCAACGCACACATCTAAAGCGACACATACGCATCATACATACAGGCATTAAACCGCACACATGCAAACATTGCAACAAGAAGTTCTCCAGCAAAAGTTACTTAAGAATCCATGAAAGACAGCACACAGGAGAGAAACCCTACTCCTGTGACATCTGCAAGAAGGATTTCAGGGCACATACAACTTTGAAAGTCCATATGCGGGTACATACTGGCTTAAAGCCCTATCTTTGCTCGTTCTGTGATAGACAGTTCGCTCAAATGGCTAGTTTTAAGCTCCATGAACGCACACATACAGGGGAGAGGCCATATGTGTGTGAGATATGTAAGAAAACGTTCTCAGATAATGGGTATTTGAAGATACATATGAGGATACATAGCGGGGATAAACCGTTTGGCTGTGATATATGCAAAAGAAGTTTCAGGGAGACGGGGCAGCTAAAAAGACATATGCGGGTCCATACTGGTGTTAAACCGTATACGTGTAAAGTTTGTAATAAGCAAATAGGGAATTTGTCTAAGCATATGCGTGTGCATGATACGGAGAAGTTCAGCTGTAGCATATGCGATAAACAGTTTAGTGTTGGCAATTTGAAGTTGCATTTAAGAGTGCATAGTGGTGAGATTCAAGGCAGGAGACTTAAATGTAGGAacgattaa
Protein Sequence: MHIQTHKTKKTFTCILCKEIFKQNKDLITHLSEKHFEGDKFKCNLCDSAFDSVKLLKKHFIVHNEKFKCSFCDKDFAKKKGLKEHLKVHTGERPYICDICGRCFPQRTHLKRHIRIIHTGIKPHTCKHCNKKFSSKSYLRIHERQHTGEKPYSCDICKKDFRAHTTLKVHMRVHTGLKPYLCSFCDRQFAQMASFKLHERTHTGERPYVCEICKKTFSDNGYLKIHMRIHSGDKPFGCDICKRSFRETGQLKRHMRVHTGVKPYTCKVCNKQIGNLSKHMRVHDTEKFSCSICDKQFSVGNLKLHLRVHSGEIQGRRLKCRND

Sequence clustering based on sequence similarity using MMseqs2