Esim017482.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Euproctis similis
Gene Symbol
foxa2
Assembly
GCA_905147225.1
Location
LR990113.1:3342875-3347745[-]

Transcription Factor Domain

TF Family
Fork_head
Domain
Fork_head domain
PFAM
PF00250
TF Group
Helix-turn-helix
Description
The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 6.5e-29 9.5e-26 90.7 0.0 1 82 68 144 68 148 0.94

Sequence Information

Coding Sequence
ATGGCAGCTAGAACAGGTGACAGAGCAAAGTGGAGAAGGAGAAAATGCTCAAAAAGTTCAACAGAAGACGACAACGATTGTGCAAGTCTAGCGTGGCTGTTAAATTTCAGATTGGAtgattttgtgaaaataaaagtgCCCGAAGATGAGCCGGTAGTGAAAGAGCCAAAGTTTGATGTTCCTGAAACGGCAGCAGTGCCTAAGAAGCCCCCATATACATATCCCGAGTTGATAGAGAGAGCCTTACGGGAAAATGGCGAGCTGACGGTATCAGCTATTTATCAATGGATCTcAGACCGTTTCCCATTCTACAAAGCAAACGACGAGCGCTGGAAAAATTCTGTGAGGCACAATCTGTCGATCAACCCACACTTTCGCAAAGGTTCGCGGGCGCCCCAGGGCGCTGGTCATCTTTGGTCACTAGCTTCTAACGCAATAGATCTACTGCCGCTAAGAGATCCCATATATTTCGAAGAGCCCCTGTCGGTTGATGACAAGAAAACTATAGAAGAAGAAAAGACTAGAGTTATCGACTATCCTAAAGTTATCGTGCTAGACGAGGCAGCTATAGCAGCTGCGAGCATTCTCCCTGATCAAGACTTATTTACTGGCAGTACAAtgtTCCTGAATCCGGTGTCGATGGAGCAAGTTGTGAGGGAGTGTGGTCTCATCACAGTTGATTAG
Protein Sequence
MAARTGDRAKWRRRKCSKSSTEDDNDCASLAWLLNFRLDDFVKIKVPEDEPVVKEPKFDVPETAAVPKKPPYTYPELIERALRENGELTVSAIYQWISDRFPFYKANDERWKNSVRHNLSINPHFRKGSRAPQGAGHLWSLASNAIDLLPLRDPIYFEEPLSVDDKKTIEEEKTRVIDYPKVIVLDEAAIAAASILPDQDLFTGSTMFLNPVSMEQVVRECGLITVD*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00123169; iTF_00124056; iTF_00121216; iTF_00299969; iTF_00973540; iTF_00851537; iTF_00449941; iTF_00049719; iTF_01342039; iTF_00444929; iTF_00685250; iTF_01061700; iTF_01084069; iTF_01532847; iTF_00711633; iTF_01533752; iTF_01093857; iTF_01092885; iTF_00924410; iTF_01094717; iTF_01362913; iTF_01440807; iTF_01361401; iTF_01221314; iTF_01339778; iTF_01439714; iTF_00888035; iTF_00809878; iTF_00808923; iTF_01338307; iTF_01064452; iTF_00622630; iTF_00667174; iTF_00757959; iTF_01531783; iTF_00830985; iTF_00850413; iTF_00017998; iTF_00907698; iTF_00273431; iTF_00171578; iTF_01192442; iTF_00040613; iTF_00237285; iTF_00043303; iTF_00042450; iTF_00039613; iTF_00041598; iTF_00172550; iTF_00363846; iTF_01435878; iTF_00445928; iTF_01030952; iTF_01028081; iTF_01029977; iTF_00425193; iTF_00185130; iTF_00185959; iTF_01151882; iTF_00785836; iTF_00783246; iTF_00784215; iTF_00785021; iTF_00905932; iTF_00038516; iTF_01526837; iTF_01525751; iTF_00726104; iTF_00036442; iTF_01230330; iTF_00037595; iTF_00906879; iTF_01332364; iTF_01062573; iTF_01076205; iTF_01360429; iTF_00404513; iTF_01197541; iTF_00706763; iTF_01166414; iTF_00637296; iTF_00677361; iTF_01501906; iTF_00280951; iTF_00441303; iTF_00908632; iTF_01075192; iTF_00157019; iTF_00636091; iTF_00794140; iTF_00823744; iTF_00771694; iTF_00373729; iTF_00745446; iTF_00448839; iTF_00374995; iTF_00147119; iTF_01027119; iTF_00383440; iTF_01487536; iTF_00001002; iTF_01491698; iTF_00120308; iTF_00071222; iTF_01246646; iTF_01534614; iTF_01180145; iTF_01285365; iTF_01179323; iTF_00300988; iTF_00301919; iTF_00446936; iTF_00326905; iTF_00967866; iTF_01119098; iTF_01118075; iTF_00111421; iTF_01116990; iTF_01259898; iTF_00274267; iTF_01264219; iTF_00951613; iTF_01084957; iTF_00928478; iTF_01538558; iTF_01424866; iTF_00122175; iTF_00176927; iTF_00931042; iTF_00932237; iTF_01173093; iTF_01073425; iTF_00621841;
90% Identity
-
80% Identity
-