Esub029571.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Eupithecia subumbrata
Gene Symbol
MBD-R2
Assembly
GCA_949316285.1
Location
OX438650.1:14086875-14101720[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 1.8e-14 1e-10 42.0 0.0 4 68 611 673 608 677 0.92

Sequence Information

Coding Sequence
ATGCCTCTTTCAGTGGGTTGCAAAGTTGATGCCAAGGATTTCAGTGAAGATTGGTTTCCAGCAAAAATTGTAGAAGTGGACTATGATGAGATGGAAGTACTAGTGAACTATGagatttctttgaaaaaACCGGATGAATGGATCAATGTAAGCAGCCCAAGACTGCGACCTTACACCGGCATCACCACCCCCAAGCCTGAACAAACACCCAAGCCTGAACAAGCGCCCAAGCCCGAACAAGCGCCCAAGCCTGAACAAGCGCCCAAGCCTGAACAAGCGCTCAAGCCAGAGCAAGAACCAGAAGAAACTTCACTACCTCTCGTCGAAACCAAAGAAGAACCCAAGACCGAGGATAAGAGCCAATATGAGATCGGAGAGAGATGCCTCGCTCGCTGGAGGGATAATAGGAGATTTGTCGCTGTCATTGACAAAGATCTGGGTGATGGCAAATTCGAAGTGATATTCGATGATGGCTTCCGTTGGCCCTGCACCATTTCCCGTCTCAGCAAGCTGAAGGACAAGCAAAACCCACTCACCATAGACACAAGTGTGGATCTATCTAGCGGAGCTCCTTCGCCGATCTCACAAGGAGGTCCTAGTTGCAACTCTCCCTCGCCGGTCCCAGCTTTCCACACGCATTTATTTGATCCTACTAGAGATTATTTAGGTTCTAAATCTGAACGTCGAGAGCAAAAACGAAAGTTGAACATAAAAGAGATTTTCAACATTGGACAGAAGAAGGCGAAGGTGCCAAAGGTTGAGAAAGATAAAACGCCTAAAGAGAAGAAGGTGGTTAAGAAAGTTGTTAAGCCGAAGCCAAAGATCAACTCTAAATTTGAAAAGCCGTGTATACCGGATGCTGTAGCGTCCATTATTGGCACgattactgaaataaaaaaagaatcaaaagattttaaaatgGATATTGATGTCTTGGAACAGCCTGATGATTCTCTAGATTCTAAATCCGATCTGGATATGattgaaGAAGAAGACAAATTGGAAAGATTTGATAAACCAGACCAAAAGAAGCATGATGAAGTGATCGACAAAATGAGAGAAGTTATAAGTAAGCTGGAAGATAGAATCAAAGAAGAATGCTTTTCACCTAAATCAGTACCTGAAGAAAAACCAATTCTAGAAGAACCACAAACTATAAACTTTGATCCACCAATTACTGATATTCTGATAAAAGATATCAAAACAACTATGGATAATAAAGAAGTGGTTCCTCTCCTCACAACACCAACTTTAAAACTAGAGGCAAATGACACTTCGACCACAGATATAGAAGTATCGATCGTAGACGTCCCATCGCCGAGCTTGATCGACACGTCTGATGCCGACTTCGAGAAAATAGTACCTGACGATGACTCAACGAAGTCGGACATCGAAATGGGCCCCGAATCGCCGCGACTCGATCTCGAATCGCAGCCAATCCTTGTCGATATCGACGCACCGCTCGATATCGACCAGCCAGACGATTTACCAGTCATAAAGAAATCCAAAAAGCTTAAGATTAAAGACTTTGTCAAGAAGCCTAAGAAGACGAAAAAGGAACAGAAAAAGAAGCTGCTGAACCAGAAATGGAGAGAGGTCGACAAGGTTAAGAACGAACTGGCCGAGATGAGGATCAAAATGAAAGAAATGATGCTTGAAATCGAAAGGGAGAAACAGGCTGGCGGTGGCATCCCTCTGCCTGAGAGCAGCCTTCTCCCGAACGAGTGGGCGTGCCACTGGGTGAACGGCCAGCCCGTGGGCAAGGTCAGCGAGATGGAGGCGGAGGCCAAAACGGACGCGAGTGGGAAGCCGGTGTTGCCGCGGCGTAGCGTCGAGGTGGTGGACAAGCGGCTGCCGGAAGGCTGGACCAAGCACATGGTGCGCCGCTCCGTGGGACACTCGGCCGGGAAGTGGGACGTCGTGCTTGTGAACCCAGAAAACCGTAGATTCCACACCAAGACCGACATGCGGAACTTCCTCGAAACAGCTGACGAGACTGTCAAAGCTTACGAATTTGCTCTCATGGACTTCGGCGTTCATTTGAAGCTCGCGCGCAAAATGGGCTGGATCGTCAGCACTCCAGACGGGATCGCCGAGGCGCCGGAGACCATCCTACCCGCTGATAGCACGAGCTGCCTGTCTCCGCTGGTGAAGAGAAAACCTTTGAGTCTTAAGAGAAGGCCGGCAGGGTTGAAAATGAAAGATAAGGCGAAGAAGCGGCCTATCAAGCTGAAGTTGCAGCGGAGATCGCATACATACGATTCGCAACTAATCGACGTGGAGGGCGAAACAATGTTGCAGGCGGAACCAGAACCGCCTCCGATGCCGGCACTTGAGGATGGTTACGTGTGGGTCGGCTCGCTAAAAGTACAGATAATCGACACCCTCCTACGCTGTCCAGCAGAAGGCTGCTTCAAAAACTTCCGGAACAACACCCTTCTTAAAATGCACATCAAACACTATCACCGGGAGCTTCGCAAGATGATGGGCGCGACGCCCAAAGTACTAGACCTCGCAGCCGCTCGGACCAAGCCGACCGCCGCCGAACTCGCCCGATCTGACTCTAAAGGCCTCAAGGTCAAGATAAACCGTCCGCCGAAACGCGACGAACCCAGACACGAATACAAACAAGAACTAGAATTCGAGCCATTGCACACTCCAACGAAGAACGAATCGTTTCCGAAAATACCGCGCAGCCAGGACTCTCCAAAACTACGCAATGCGCTTGTCAACAAACCAGTGAAACGCCCCAAGGTCTTGCTACCAGTGAGGAGGCTAGAATCGGAGCTGAATCCAGAATTCATGGAAGACGACGATTTTGAAATGCCCACTCAAGCGAAACCTCCCACAGATGTCCTCGACTTCGAAGCTGCTATTTCCACCCACACGGTAACCAAACCACTTGAACTGAAGAAGAAAGGAGATAAGAAGAAATCGTTCGCGTCATTCTCTAAGAATATTAGTGAGGATGAGGAATGGTTTGCTATGAACTCTGATGAGCTGGACACTAGGTCGAGTTTCCCGCGCTCCGGTACGCCTGATGATTCAAAGATTATTGACCCGAAGACTGGCTTTATGATGTCATCTGATGCTATGGACGATCCAATGGATCCTTCATGTTACACTTTCACAGAGACTGGCCAGCGCATCAAGATAGTCCGCATGAGGCGCGAAGAGATCATCAACTGTCACTGCGGCTTCCGCGAAGAGGACGGTCTGATGGTGCAGTGCGAGCTCTGTCTGTGCTGGCAGCACGCTCTTTGCCATAATATACACAGAGAATCTGAGGTCCCAGAAAAGTACACTTGTAGCATCTGCCTGAACCCCCGCCGCGGGCGCCGCTCCAAGCGCTTCCTGCACGACCAGGACCGACTGTACGATGGAATACTGCCGGGCGCCAAGGCGGACGAGTGTGTGCGACGGTCTCACGAGCTCTCCGGGAATCTGCTGAGAATAGAGGACGCTCTGCACGCGCTGCGGGTCAAGTCTTATGTGGCCACTAAAAAAGACCATCCGAAACTGTATCTCTGGGCCAAAGACTGGGAGCAGGCAGAGATGACATACAAGATGAACTCTGATTACTCCGACCTCAGCATCATGATCAATGGAATGGACAAGGAGAACCTTCCGATGAAGCCTGAAGAACCTCATCTCATGGGCATTCGCGGGGCGAGCGAGGACGATCCTGATAGCGACAGATACTCCCAACGAGACAGCCAGCTCGGCTCGCAGGCTCTGCTCAGCGGCCTGCTCTCCAGCCCGAGCGCTGCGTCCTTGGAACTGCCCATCAGCACCTCGGAACTGGAGCGTCTTGCTAAAACTGTTCAAGCGGCAGCCGAATGGCACGGGCAGGCCGCGCCGGTCCCGCAGCCCGAAGCGGCCATCGACAACGACGTGTGTCGCGACCGGCTGCTGAAACACATCATGCGGTGCCAGGCGTCGCTGGACTCCAGAATGGACTCTATCGATGCACAAGTCGCCgAGTTGGAATCACAAGATCCATCGTTCGGCGAGCACTATGAAACAGCAGAATACTACCCGCGCGTCAAGCAGACCGTTCAGATGCTGATGCGCGATCTCGACACCATGGAGGAACTGGGTCTCATCACATAA
Protein Sequence
MPLSVGCKVDAKDFSEDWFPAKIVEVDYDEMEVLVNYEISLKKPDEWINVSSPRLRPYTGITTPKPEQTPKPEQAPKPEQAPKPEQAPKPEQALKPEQEPEETSLPLVETKEEPKTEDKSQYEIGERCLARWRDNRRFVAVIDKDLGDGKFEVIFDDGFRWPCTISRLSKLKDKQNPLTIDTSVDLSSGAPSPISQGGPSCNSPSPVPAFHTHLFDPTRDYLGSKSERREQKRKLNIKEIFNIGQKKAKVPKVEKDKTPKEKKVVKKVVKPKPKINSKFEKPCIPDAVASIIGTITEIKKESKDFKMDIDVLEQPDDSLDSKSDLDMIEEEDKLERFDKPDQKKHDEVIDKMREVISKLEDRIKEECFSPKSVPEEKPILEEPQTINFDPPITDILIKDIKTTMDNKEVVPLLTTPTLKLEANDTSTTDIEVSIVDVPSPSLIDTSDADFEKIVPDDDSTKSDIEMGPESPRLDLESQPILVDIDAPLDIDQPDDLPVIKKSKKLKIKDFVKKPKKTKKEQKKKLLNQKWREVDKVKNELAEMRIKMKEMMLEIEREKQAGGGIPLPESSLLPNEWACHWVNGQPVGKVSEMEAEAKTDASGKPVLPRRSVEVVDKRLPEGWTKHMVRRSVGHSAGKWDVVLVNPENRRFHTKTDMRNFLETADETVKAYEFALMDFGVHLKLARKMGWIVSTPDGIAEAPETILPADSTSCLSPLVKRKPLSLKRRPAGLKMKDKAKKRPIKLKLQRRSHTYDSQLIDVEGETMLQAEPEPPPMPALEDGYVWVGSLKVQIIDTLLRCPAEGCFKNFRNNTLLKMHIKHYHRELRKMMGATPKVLDLAAARTKPTAAELARSDSKGLKVKINRPPKRDEPRHEYKQELEFEPLHTPTKNESFPKIPRSQDSPKLRNALVNKPVKRPKVLLPVRRLESELNPEFMEDDDFEMPTQAKPPTDVLDFEAAISTHTVTKPLELKKKGDKKKSFASFSKNISEDEEWFAMNSDELDTRSSFPRSGTPDDSKIIDPKTGFMMSSDAMDDPMDPSCYTFTETGQRIKIVRMRREEIINCHCGFREEDGLMVQCELCLCWQHALCHNIHRESEVPEKYTCSICLNPRRGRRSKRFLHDQDRLYDGILPGAKADECVRRSHELSGNLLRIEDALHALRVKSYVATKKDHPKLYLWAKDWEQAEMTYKMNSDYSDLSIMINGMDKENLPMKPEEPHLMGIRGASEDDPDSDRYSQRDSQLGSQALLSGLLSSPSAASLELPISTSELERLAKTVQAAAEWHGQAAPVPQPEAAIDNDVCRDRLLKHIMRCQASLDSRMDSIDAQVAELESQDPSFGEHYETAEYYPRVKQTVQMLMRDLDTMEELGLIT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00699237; iTF_00699188; iTF_00706093; iTF_00706035; iTF_00698336; iTF_00698389; iTF_00702056; iTF_00702008; iTF_00705096; iTF_00705032; iTF_00702921; iTF_00702979; iTF_00696491; iTF_00697425; iTF_00697366; iTF_00701140; iTF_00701086; iTF_00700190; iTF_00700143;
90% Identity
iTF_00702979;
80% Identity
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