Basic Information

Insect: Eupithecia exiguata
Gene Symbol: lig1
Assembly: GCA_947086465.1
Location: OX352249.1:8987684-9008169[+]

Transcription Factor Domain

TF Family: SRF
Domain: SRF domain
PFAM: PF00319
TF Group: Helix-turn-helix
Description: Serum response factor (SRF) is a ubiquitous nuclear protein important for cell proliferation and differentiation. SRF function is essential for transcriptional regulation of numerous growth-factor-inducible genes, such as c-fos oncogene and muscle-specific actin genes. A core domain of around 90 amino acids is sufficient for the activities of DNA-binding, dimerisation and interaction with accessory factors. Within the core is a DNA-binding region, designated the MADS box [2], that is highly similar to many eukaryotic regulatory proteins: among these are MCM1, the regulator of cell type-specific genes in fission yeast; DSRF, a Drosophila trachea development factor; the MEF2 family of myocyte-specific enhancer factors; and the Agamous and Deficiens families of plant homeotic proteins. In SRF, the MADS box has been shown to be involved in DNA-binding and dimerisation [1]. Proteins belonging to the MADS family function as dimers, the primary DNA-binding element of which is an anti-parallel coiled coil of two amphipathic α-helices, one from each subunit. The DNA wraps around the coiled coil allowing the basic N-termini of the helices to fit into the DNA major groove. The chain extending from the helix N-termini reaches over the DNA backbone and penetrates into the minor groove. A 4-stranded, anti-parallel β-sheet packs against the coiled-coil face opposite the DNA and is the central element of the dimerisation interface. The MADS-box domain is commonly found associated with K-box region see (IPR002487).
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.11 3.9e+02 0.9 0.1 21 35 822 836 821 837 0.91

2 9 0.011 40 4.0 0.1 20 35 857 872 838 873 0.78

3 9 0.02 72 3.2 0.0 20 35 875 890 875 891 0.94

4 9 0.02 72 3.2 0.0 20 35 893 908 893 909 0.94

5 9 0.02 72 3.2 0.0 20 35 911 926 911 927 0.94

6 9 0.02 72 3.2 0.0 20 35 929 944 929 945 0.94

7 9 0.02 72 3.2 0.0 20 35 947 962 947 963 0.94

8 9 0.02 72 3.2 0.0 20 35 965 980 965 981 0.94

9 9 0.02 72 3.2 0.0 20 35 983 998 983 999 0.94

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.11	3.9e+02	0.9	0.1	21	35	822	836	821	837	0.91
2	9	0.011	40	4.0	0.1	20	35	857	872	838	873	0.78
3	9	0.02	72	3.2	0.0	20	35	875	890	875	891	0.94
4	9	0.02	72	3.2	0.0	20	35	893	908	893	909	0.94
5	9	0.02	72	3.2	0.0	20	35	911	926	911	927	0.94
6	9	0.02	72	3.2	0.0	20	35	929	944	929	945	0.94
7	9	0.02	72	3.2	0.0	20	35	947	962	947	963	0.94
8	9	0.02	72	3.2	0.0	20	35	965	980	965	981	0.94
9	9	0.02	72	3.2	0.0	20	35	983	998	983	999	0.94

Sequence Information

Coding Sequence: ATGGCCCAAAGAAGCATTACATCCTTCTTCAAAATCACCCCTCCAAAGAGTGCTGTTGACAAGAAAGTACCAGCTGCTGTCAAAGAAGAGGAGAATGAGACATCACCAGTTCCCAATGGGAAAGAAAAGAGATTGTCCAAAAGACCCAGGTTGCATAGTTCCGGGAGTGAGTCTGAAGCACTAGATACTAGCAAAGTATTGCCTACTGCTGGTTCAGAGAAGAAAAAGAAACCAAAACGACAGAGAATAATAAGTTCGGGCAGTGAACCAGAACCATCACGAGCAGACACACCTTCACCAAAATCTAACAAAGACTCAGCTCCAGAAGCAGAAGCTCAATCTGAGGTCAAATCACCAAAAGAAGATGAAATCAAGATTAAAGTGGAAAAGACTGACTCTCCTAAAACCTATGCATCACCTAAAAGTAAAAAAGGGAGACCTAAGCTTCTAAAAGAGGTCAACAAAACTCCAAAAAAATTAATATCTCCAAAGCAAGAGACATCTCCAAAAACTGTTTCAGAAAAATCTCCTAAATCTGAAAGCGGGTCTCCTAAGAGGAGTCCTTCTCCAAAAACTAAGAAAGTGAAAAAAGAAAAGAAGGAAGTGCTGAGCAGTGGAAGAGATTCAGAAATGAAGGAAAATATTGTAAATAAGAAAGGTTCAGCAGATGTTGAAGACACAGCTACTGATGTAACTCCAGTTGCAGAAACAGAGTACAACCCGGGCAAGTCCAAATACCACCCGGTCAGAGACGCGTGCTGGGCGCGCGGACAGCCAGTGCCCTACCTCGCGCTGGCCAAGACCTTCGAGGCTATAGAGCCTATCTCAGCCCGGCTGAAGATAATCGAGATACTTAGCAATTACTTCAGATCCGTGATAGTCCTGACTCCTGCAGACCTGCTGCCGAGTGTGTACATGTGCCTCAACCAGCTGGCGCCTGCCTACCACAGTTTAGAGCTCGGCATAGCAGAAACGTACCTGATGAAGGCCGTGGGCGCCTGCACGGGGCGCACGCTGGCGCAGCTCCGCAACGCCGCGCGCTCCGCCGACCTGGGCACCGTGGCCGAGGGCGCGCGCGCCGCGCAGCGCACCATGTTCCCGCAGCCTCCTCTTACGTGCAGGAAGGTGTTCGCGGCGCTCAAGGAGGTCGCGCATACGACTGGTCAATCGTCGGTAAACAAGAAAATCGCCAAGATCCAGTCCCTCTACGTCGCGTGTCGACATTCAGAAGCTCGCTACTTGATCAGGTCCCTAGAAGGCAAGCTCCGTATCGGTCTAGCGGAGCAGTCGGTGCTGCAAGCTCTGGCGCTGGCCACCGCCATGACGCCCCCCGACCCCACCGGGGTCAAGGTGTTGGATGCGTCCCGGGGAATGTCGCAGGACAACTTCAAGGCGCGCCTAGACGAGCACTCGCTGATAATAAAGACTACCTACTGCGAGTGTCCCAACTACGACGCCATTATCCCGGCGCTACTGTCCGACGGAGTGTCGTCCTTGCCGCGGCACTGCCGGCTGACCGTGGGCGTGCCGCTCAAGCCCATGCTGGCGCATCCCACTAAGGGGGTGCACGAGGTCTTCAACCGGTTTGAGGGCTGTGCGTTCACGTGCGAGTGGAAGTACGACGGCGAGCGCGCGCAGATCCACGTGCCGAGCGGAGTGGATGGTGCGCCGGCGTTGGACCAAGCAGCTGTTTTCAGCCGAAACCAGGAGAACAACACCAGCAAGTACCCGGACGTGCTCCGCCGCCTGCCCTCGTTGCTGAAGGACACCGTCAAGGACTGCGTGCTGGATTGTGAGGCCGTAGCCTACGATACAGAGAACAACCAGATACTGCCCTTCCAGATCCTTTCAACGCGCAAACGCAAAGACGCCTCGGAAGCTGACATCAAGGTGCAAGTGTGTGTGTTTGTGTTCGACCTTCTGTACCTGAACGGGGCGCCCCTCGTGCGCGAGCCGCTGGAGAAGAGGCGCGCCCTTCTAAAGGAACACTTTAATGAAGTGCCAGGTGAATGGCAGTTCGCGACGTCCCGCGACTGCAAGGATATGGAGGAGGTGCAGCAGTTCCTGGAGGAGTCGGTGAAAGGCTCCTGCGAGGGGCTCATGATTAAGACGCTGCGCGGCGACCACGCCAAGTACGACATCGCTCGCCGCTCGCACAACTGGCTCAAGCTCAAGAAGGACTACCTAGACGGCGTGGGCGACACCATCGACGTGGTTATAATCGGTGCGTACCACGGGCGCGGCAAGCGACGCGCCACCTACGGCGGGTTCCTGGCCGCCTGTCGGGACGCAGACACTGACTCCTACCAGACGCTGTGCAAGCTGGGCACCGGCTTCAGCGACGAGGACCTCGTGACACTCACTGACACGCTGAAGCAGCACGAGATCCCGCAGCCCAGGAACTACTACAGGAGCAACAACACATGCAAATTGATACTCATCAACGTGTTTAATGCACAGGAAAAAAGTGCGTGCGAGCTCTCTGTGGAGTTTGGAGTACGGATAGCTGCAAGATTTAAAAATACGTGCGAGCTCTCTGTGGAGTTTGGAGTACGGATAGCTGCAAGATTTAAAAATGCGTGCGAGCTCTCTGTGGAGTTTGGAGTACGGATAGCTGCAAGATTTAAAAATGCGTGCGAGCTCTCTGTGGAGTTTGGAGTACGGATAGCTGCAAGATTTAAAAATGCGTGCGAGCTCTCTGTGGAGTTTGGAGTACGGATAGCTGCAAGATTTAAAAATGCGTGCGAGCTCTCTGTGGAGTTTGGAGTGCGGATAGCTGCAAGATTTAAAAATGCGTGCGAGCTCTCTGTGGAGTTTGGAGTACGGATAGCTGCAAGATTTAAAAATGCGTGCGAGCTCTCTGTGGAGTTTGGAGTACGGATAGCTGCAAGATTTAAAAATGCGTGCGAGCTCTCTGTGGAGTTTGGAGTGCGGATAGCTGCAAGATTTAAAAATGCGTGCGAGCTCTCTGTGGAGTTTGGAGTACGGATAGCTGCAAGATTTAAAAAAATACATAAGGGACTTACTGAATAA
Protein Sequence: MAQRSITSFFKITPPKSAVDKKVPAAVKEEENETSPVPNGKEKRLSKRPRLHSSGSESEALDTSKVLPTAGSEKKKKPKRQRIISSGSEPEPSRADTPSPKSNKDSAPEAEAQSEVKSPKEDEIKIKVEKTDSPKTYASPKSKKGRPKLLKEVNKTPKKLISPKQETSPKTVSEKSPKSESGSPKRSPSPKTKKVKKEKKEVLSSGRDSEMKENIVNKKGSADVEDTATDVTPVAETEYNPGKSKYHPVRDACWARGQPVPYLALAKTFEAIEPISARLKIIEILSNYFRSVIVLTPADLLPSVYMCLNQLAPAYHSLELGIAETYLMKAVGACTGRTLAQLRNAARSADLGTVAEGARAAQRTMFPQPPLTCRKVFAALKEVAHTTGQSSVNKKIAKIQSLYVACRHSEARYLIRSLEGKLRIGLAEQSVLQALALATAMTPPDPTGVKVLDASRGMSQDNFKARLDEHSLIIKTTYCECPNYDAIIPALLSDGVSSLPRHCRLTVGVPLKPMLAHPTKGVHEVFNRFEGCAFTCEWKYDGERAQIHVPSGVDGAPALDQAAVFSRNQENNTSKYPDVLRRLPSLLKDTVKDCVLDCEAVAYDTENNQILPFQILSTRKRKDASEADIKVQVCVFVFDLLYLNGAPLVREPLEKRRALLKEHFNEVPGEWQFATSRDCKDMEEVQQFLEESVKGSCEGLMIKTLRGDHAKYDIARRSHNWLKLKKDYLDGVGDTIDVVIIGAYHGRGKRRATYGGFLAACRDADTDSYQTLCKLGTGFSDEDLVTLTDTLKQHEIPQPRNYYRSNNTCKLILINVFNAQEKSACELSVEFGVRIAARFKNTCELSVEFGVRIAARFKNACELSVEFGVRIAARFKNACELSVEFGVRIAARFKNACELSVEFGVRIAARFKNACELSVEFGVRIAARFKNACELSVEFGVRIAARFKNACELSVEFGVRIAARFKNACELSVEFGVRIAARFKNACELSVEFGVRIAARFKKIHKGLTE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: -
90% Identity: -
80% Identity: -