Basic Information

Gene Symbol
KLHL34
Assembly
GCA_944548335.1
Location
CALYMU010000903.1:546853-570368[+]

Transcription Factor Domain

TF Family
BTB
Domain
zf-C2H2|ZBTB
PFAM
PF00651
TF Group
Zinc-Coordinating Group
Description
The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 5 4.1e-10 1.4e-07 32.4 0.0 1 40 45 83 45 92 0.92
2 5 1.3e-08 4.4e-06 27.6 0.0 6 40 106 139 101 148 0.88
3 5 1.3e-08 4.4e-06 27.6 0.0 6 40 162 195 157 204 0.88
4 5 1.3e-08 4.4e-06 27.6 0.0 6 40 218 251 213 260 0.88
5 5 8.6e-16 2.9e-13 50.7 0.0 6 106 274 371 269 375 0.88

Sequence Information

Coding Sequence
ATGAAGCCTCTCGACCACTACACCAATGGAGACGATGGTTGTGACTCGGAAGGCAGCGAGGGCGAAGCGGACGGGGAAACAGAAGACCTATCCCTCGTGGACGTGGGAGCGCCCGCGCGGGCTCTCGGAGCCCTGAACGCGCTGCGCAAGTCTCGTCAGCACTACGACGTGGTGCTAGTGGCGGGCGGCGCCGAGGTGCCGGCGCACCGGGCCGTGCTGGCCGCCGCCTCGCCCTACCTGCTGGAGGCGCTAGCCCCCGCCTCGCCGCCCGGCGCGCCTTACCCCGTGCAGGTGAGTGCAGTGCATGTGACGTACAAGTCTCGTCAGCACTACGACGTGGTGCTAGTGGCGGGCGGCGCCGAGGTGCCGGCGCACCGGGCCGTGCTGGCCGCCGCCTCGCCCTACCTGCTGGAGGCGCTAGCCCCCGCCTCGCCGCCCGGCGCGCCTTACCCCGTGCAGGTGAGTGCAGTGCATGTGACGTACAAGTCTCGTCAGCACTACGACGTGGTGCTAGTGGCGGGCGGCGCCGAGGTGCCGGCGCACCGGGCCGTGCTGGCCGCCGCCTCGCCCTACCTGCTGGAGGCGCTAGCCCCCGCCTCGCCGCCCGGCGCGCCTTACCCCGTGCAGGTGAGTGCAGTGCATGTGACGTACAAGTCTCGTCAGCACTACGACGTGGTGCTAGTGGCGGGCGGCGCCGAGGTGCCGGCGCACCGGGCCGTGCTGGCCGCCGCCTCGCCCTACCTGCTGGAGGCGCTAGCCCCCGCCTCGCCGCCCGGCGCGCCTTACCCCGTGCAGGTGAGTGCAGTGCATGTGACGTACAAGTCTCGTCAGCACTACGACGTGGTGCTAGTGGCGGGCGGCGCCGAGGTGCCGGCGCACCGGGCCGTGCTGGCCGCCGCCTCGCCCTACCTGCTGGAGGCGCTAGCCCCCGCCTCGCCGCCCGGCGCGCCTTACCCCGTGCAGGAAGTGGAGGGCGAAGCCCTACGCGCCCTGGTCGAATACGCGTACACCGGGCGACTGGTGGTCCGCGACGCACTGGAGGCGCGGCGGCTGTACCGCGCGGCCTGGCGGCTGCGGCTggaggcggcgcgcgcgcacctcGCCGAGAGGCTGCTGCGACGGCTACAGCCGCAGGATTGTCTCGCCGTGCGCGCGCTGCCCGGGCTCACGACCGAGCAGTTGCAGGTCTTGGATAAATATATTGCTGATAATTTCGACGAGCTATGTTCGTGCGGAGCGCTCGCCACCTTGCCACAGATCCGCATCGAGGTGATGCGGGAGAGCGCGGGCTCGGGCGGGGACGAGGCGCCGCTCACTGTCGCTGATGCGGCACTGGCCTGGCTGCGGGAACAGCCCACCACGGAGAGAGATTTCACAGAGCTGTGTTCTCGAGCGCACCTGGTGTTCGTGGACGGGCGCGGGCTGCTGCGCGACTGCGGCGAGctgccggcggcggcgggcgacgCGCCCGAGCTGCAGCAGTACCGGCGCGAGAGCGCGGCCCGCAAgcgagcgcccgccgcgccgccgcccgcgcagcgagcggggcagctcggcgcacggactgacggCACCGCGTGCGCAGTTCTAGGCGCCCGAGGCTGCCTCGGCGGCGGTTGCAGAGCGCTGCTGTCAGTGAACGGTCGGCTGGCGGGGGCGCTGGCCGTGTGGTCGGGGGTCGCGCGCGGGGCCGCCGCGGGCCCCGGCGCCGCCTTGCAGGGCGGGGCCCGCATCGCCAGTCTCAATGGAGGCAGATGCGCTCTGGGCGCGGTGGCGGTGGACGGTCTGCTGCTGGCGTGCGGCGGGTACGACCGCGCGCGCGTGCTGCGCTCCGCCGAGCTGTACCACCCGCGCAGCAACACGTGGGCCGCCGCGCCCGGCATGCGCCGCGAGCGGGCGCGCTTCCCCGCCGCGCGCCTCCGCGACACCGTCTACGTCATAGGCGGCAGTGACGGTCACGCAGAGCTGGACTCAGTGGACGCGTACAGCGAGGGGGCGTGGCGCGGGGTCGCGCGGCTGCCTCTGGCGCTGTCGCACGCGGCGGGGGCCGCGGACCCCGCCGCGGGGGTCCTCTACGTGGCGGGCGGCTGGGCGCAGGGGACCTATCTGCGCCGCGCCTTCAAGTACAGCCCTGAGGAGGACGTGTGGAGCGAAGCGCCGCCTTTGAATACAGGTCGTGCGCAATGCGCGGGCGTGCTTTGGGAAGGCTGCATGTGGGTACTTGGCGGATGCGACGCGTGGCACTGCCTCGCCTCCACCGAGCGACTGGTGGTGAGCGAGGGGGCCTGGGCCGCGGGGCCCGCGCTGCCGAGCGCGCGCCGCTCCGTGGGGGGCGCCGTGTGGCGGGGCCGCCTCGTCTCCGTGGGGGGGTCGGACGGCGCCGCCAGCCTGCGCCGCACGGACTGGCTCGAGCCGGACTGCGCCTCGCACACTCCGCAGGCGGAGGTACAACAAGAAGGCGCAAGCCTATGGCAAGCCGGCCCCCTACTCCGCAAAGCGCGCGCGGGGCCAGGCGTCGCCGTGCTAGGCGAAGCCCTATACGCCGTCGGGGGCTTCGACGGGAAAGACTTCCTCGCGTGCGCGGAGTGTCTTCTACACCCCGACGGGGAGTGGACGGCGCTGGCCATGCACGCCGCGCCCCAGGGGGGGCTTGACAACAAGGGGGGCTCGGGGGAACAGGGGGGGCTTGATAACAAGGGGGGAAAGGGGGGGCTCAATGATATAGCGGAGGAGATCGTGAAGGATGACTTGGTGAAGGATTTGAAGAAGAAGTTGTCGATTGATGGAGGAATGGATAATTCTGAGGATGTATCAGAGAAGCGGACAGACAACCAGACCCCCGCGACCGCCGCGCACTAA
Protein Sequence
MKPLDHYTNGDDGCDSEGSEGEADGETEDLSLVDVGAPARALGALNALRKSRQHYDVVLVAGGAEVPAHRAVLAAASPYLLEALAPASPPGAPYPVQVSAVHVTYKSRQHYDVVLVAGGAEVPAHRAVLAAASPYLLEALAPASPPGAPYPVQVSAVHVTYKSRQHYDVVLVAGGAEVPAHRAVLAAASPYLLEALAPASPPGAPYPVQVSAVHVTYKSRQHYDVVLVAGGAEVPAHRAVLAAASPYLLEALAPASPPGAPYPVQVSAVHVTYKSRQHYDVVLVAGGAEVPAHRAVLAAASPYLLEALAPASPPGAPYPVQEVEGEALRALVEYAYTGRLVVRDALEARRLYRAAWRLRLEAARAHLAERLLRRLQPQDCLAVRALPGLTTEQLQVLDKYIADNFDELCSCGALATLPQIRIEVMRESAGSGGDEAPLTVADAALAWLREQPTTERDFTELCSRAHLVFVDGRGLLRDCGELPAAAGDAPELQQYRRESAARKRAPAAPPPAQRAGQLGARTDGTACAVLGARGCLGGGCRALLSVNGRLAGALAVWSGVARGAAAGPGAALQGGARIASLNGGRCALGAVAVDGLLLACGGYDRARVLRSAELYHPRSNTWAAAPGMRRERARFPAARLRDTVYVIGGSDGHAELDSVDAYSEGAWRGVARLPLALSHAAGAADPAAGVLYVAGGWAQGTYLRRAFKYSPEEDVWSEAPPLNTGRAQCAGVLWEGCMWVLGGCDAWHCLASTERLVVSEGAWAAGPALPSARRSVGGAVWRGRLVSVGGSDGAASLRRTDWLEPDCASHTPQAEVQQEGASLWQAGPLLRKARAGPGVAVLGEALYAVGGFDGKDFLACAECLLHPDGEWTALAMHAAPQGGLDNKGGSGEQGGLDNKGGKGGLNDIAEEIVKDDLVKDLKKKLSIDGGMDNSEDVSEKRTDNQTPATAAH

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
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90% Identity
-
80% Identity
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